Growth differentiation factor-15 and all-cause mortality in
patients with suspected myocardial infarction

J 2019

Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction

WALTER, Joan, Thomas NESTELBERGER, Jasper BOEDDINGHAUS, Raphael TWERENBOLD, Lukas CROTON et. al.

Základní údaje

Originální název

Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction

Autoři

WALTER, Joan (756 Švýcarsko), Thomas NESTELBERGER (756 Švýcarsko), Jasper BOEDDINGHAUS (756 Švýcarsko), Raphael TWERENBOLD (756 Švýcarsko), Lukas CROTON (756 Švýcarsko), Patrick BADERTSCHER (756 Švýcarsko), Karin WILDI (756 Švýcarsko), Desiree WUSSLER (756 Švýcarsko), Jeanne du Fay DE LAVALLAZ (756 Švýcarsko), Christian MUELLER (756 Švýcarsko, garant), Maria Rubini GIMENEZ (756 Švýcarsko), Christian PUELACHER (756 Švýcarsko), Nikola KOZHUHAROV (756 Švýcarsko), Beata MORAWIEC (756 Švýcarsko), Katharina RENTSCH (756 Švýcarsko), Oscar MIRO (756 Švýcarsko), F. Javier MARTIN-SANCHEZ (756 Švýcarsko), Piotr MUZYK (756 Švýcarsko), Nicolas GEIGY (756 Švýcarsko), Dagmar I. KELLER (756 Švýcarsko), Tobias REICHLIN (756 Švýcarsko), Jens LOHRMANN (756 Švýcarsko), Ewalina BISKUP (756 Švýcarsko), Wanda KLOOS (756 Švýcarsko), Beatriz LOPEZ (724 Španělsko), Carolina Fuenzalida INOSTROZA (724 Španělsko), Esther Rodriguez ADRADA (724 Španělsko), Damian KAWECKI (616 Polsko), Piotr MUZYK (616 Polsko), Ewa NOWALANY-KOZIELSKA (616 Polsko), Jiří PAŘENICA (203 Česká republika, domácí), Kathrin MEISSNER (756 Švýcarsko), Caroline KULANGARA (756 Švýcarsko), Riham MAHFOUZ (756 Švýcarsko), Katharina RENTSCH (756 Švýcarsko) a Arnold VON ECKARDSTEIN (756 Švýcarsko)

Vydání

International Journal of Cardiology, Clare, Elsevier Ireland Ltd. 2019, 0167-5273

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.229

Kód RIV

RIV/00216224:14110/19:00110562

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ijcard.2019.04.088

UT WoS

000476878000050

Klíčová slova anglicky

Biomarkers; Acute coronary syndromes; Mortality/survival

Štítky

14110211, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 9. 2019 10:15, Mgr. Tereza Miškechová

Anotace

V originále

Background: To assess the prognostic performance of Growth differentiation factor-15 (GDF-15) concentrations in unselected patients presenting with suspected acute myocardial infarction (AMI) and adjudication based on high-sensitivity cardiac troponin (hs-cTn). Methods and results: In an ongoing prospective multicenter diagnostic study, consecutive patients presenting with suspected AMI to the emergency department and available GDF-15 and hs-cTnT concentrations were included. Adjudication of AMI was performed central by two independent cardiologists using all available clinical information including cardiac imaging and serial hs-cTn concentrations. Overall, 718 patients were included, with 23% (162/718) having an adjudicated diagnosis of AMI. The cumulative incidence of death within 2 years was 19% in patients with AMI (30 deaths in 162 patients) versus 5% in patients without AMI (25 deaths in 556 patients; P < 0.001). In AMI patients, GDF-15 provided an AUC of 0.89 (95% confidence interval [CI] 0.83-0.94) for 2-year death versus 0.55 (95% CI 0.44-0.66) for hs-cTnT (P < 0.001). A GDF-15 cutoff of <= 1560 ng/L predicted 2-year survival in 47% (76/162) of AMI patients and had 100% sensitivity (95% CI 88-100%) for 2-year death. In patients without AMI, GDF-15 provided an AUC of 0.83 (95% CI 0.76-0.89) versus 0.76 (95% CI 0.67-0.85) for hscTnT (P= 0.096). A GDF-15 cutoff of <= 886 ng/L predicted 2-year survival in 37% (203/556) of non-AMI patients and had 100% sensitivity (95% CI 86-100%) for 2-year death. Conclusions: GDF-15 concentrations at emergency department presentation have a high predictive accuracy for all-cause death in patients with suspected AMI and allow the identification of a large proportion of AMI patients with very low mortality risk. (C) 2019 Elsevier B.V. All rights reserved.

Citovat

WALTER, Joan, Thomas NESTELBERGER, Jasper BOEDDINGHAUS, Raphael TWERENBOLD, Lukas CROTON, Patrick BADERTSCHER, Karin WILDI, Desiree WUSSLER, Jeanne du Fay DE LAVALLAZ, Christian MUELLER, Maria Rubini GIMENEZ, Christian PUELACHER, Nikola KOZHUHAROV, Beata MORAWIEC, Katharina RENTSCH, Oscar MIRO, F. Javier MARTIN-SANCHEZ, Piotr MUZYK, Nicolas GEIGY, Dagmar I. KELLER, Tobias REICHLIN, Jens LOHRMANN, Ewalina BISKUP, Wanda KLOOS, Beatriz LOPEZ, Carolina Fuenzalida INOSTROZA, Esther Rodriguez ADRADA, Damian KAWECKI, Piotr MUZYK, Ewa NOWALANY-KOZIELSKA, Jiří PAŘENICA, Kathrin MEISSNER, Caroline KULANGARA, Riham MAHFOUZ, Katharina RENTSCH a Arnold VON ECKARDSTEIN. Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction. International Journal of Cardiology. Clare: Elsevier Ireland Ltd., 2019, roč. 292, October, s. 241-245. ISSN 0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2019.04.088.

@article{1551977,
   author = {Walter, Joan and Nestelberger, Thomas and Boeddinghaus, Jasper and Twerenbold, Raphael and Croton, Lukas and Badertscher, Patrick and Wildi, Karin and Wussler, Desiree and de Lavallaz, Jeanne du Fay and Mueller, Christian and Gimenez, Maria Rubini and Puelacher, Christian and Kozhuharov, Nikola and Morawiec, Beata and Rentsch, Katharina and Miro, Oscar and MartinandSanchez, F. Javier and Muzyk, Piotr and Geigy, Nicolas and Keller, Dagmar I. and Reichlin, Tobias and Lohrmann, Jens and Biskup, Ewalina and Kloos, Wanda and Lopez, Beatriz and Inostroza, Carolina Fuenzalida and Adrada, Esther Rodriguez and Kawecki, Damian and Muzyk, Piotr and NowalanyandKozielska, Ewa and Pařenica, Jiří and Meissner, Kathrin and Kulangara, Caroline and Mahfouz, Riham and Rentsch, Katharina and von Eckardstein, Arnold},
   article_location = {Clare},
   article_number = {October},
   doi = {http://dx.doi.org/10.1016/j.ijcard.2019.04.088},
   keywords = {Biomarkers; Acute coronary syndromes; Mortality/survival},
   language = {eng},
   issn = {0167-5273},
   journal = {International Journal of Cardiology},
   title = {Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction},
   url = {http://dx.doi.org/10.1016/j.ijcard.2019.04.088},
   volume = {292},
   year = {2019}
}

TY  - JOUR
ID  - 1551977
AU  - Walter, Joan - Nestelberger, Thomas - Boeddinghaus, Jasper - Twerenbold, Raphael - Croton, Lukas - Badertscher, Patrick - Wildi, Karin - Wussler, Desiree - de Lavallaz, Jeanne du Fay - Mueller, Christian - Gimenez, Maria Rubini - Puelacher, Christian - Kozhuharov, Nikola - Morawiec, Beata - Rentsch, Katharina - Miro, Oscar - Martin-Sanchez, F. Javier - Muzyk, Piotr - Geigy, Nicolas - Keller, Dagmar I. - Reichlin, Tobias - Lohrmann, Jens - Biskup, Ewalina - Kloos, Wanda - Lopez, Beatriz - Inostroza, Carolina Fuenzalida - Adrada, Esther Rodriguez - Kawecki, Damian - Muzyk, Piotr - Nowalany-Kozielska, Ewa - Pařenica, Jiří - Meissner, Kathrin - Kulangara, Caroline - Mahfouz, Riham - Rentsch, Katharina - von Eckardstein, Arnold
PY  - 2019
TI  - Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction
JF  - International Journal of Cardiology
VL  - 292
IS  - October
SP  - 241-245
EP  - 241-245
PB  - Elsevier Ireland Ltd.
SN  - 01675273
KW  - Biomarkers
KW  - Acute coronary syndromes
KW  - Mortality/survival
UR  - http://dx.doi.org/10.1016/j.ijcard.2019.04.088
L2  - http://dx.doi.org/10.1016/j.ijcard.2019.04.088
N2  - Background: To assess the prognostic performance of Growth differentiation factor-15 (GDF-15) concentrations in unselected patients presenting with suspected acute myocardial infarction (AMI) and adjudication based on high-sensitivity cardiac troponin (hs-cTn). Methods and results: In an ongoing prospective multicenter diagnostic study, consecutive patients presenting with suspected AMI to the emergency department and available GDF-15 and hs-cTnT concentrations were included. Adjudication of AMI was performed central by two independent cardiologists using all available clinical information including cardiac imaging and serial hs-cTn concentrations. Overall, 718 patients were included, with 23% (162/718) having an adjudicated diagnosis of AMI. The cumulative incidence of death within 2 years was 19% in patients with AMI (30 deaths in 162 patients) versus 5% in patients without AMI (25 deaths in 556 patients; P < 0.001). In AMI patients, GDF-15 provided an AUC of 0.89 (95% confidence interval [CI] 0.83-0.94) for 2-year death versus 0.55 (95% CI 0.44-0.66) for hs-cTnT (P < 0.001). A GDF-15 cutoff of <= 1560 ng/L predicted 2-year survival in 47% (76/162) of AMI patients and had 100% sensitivity (95% CI 88-100%) for 2-year death. In patients without AMI, GDF-15 provided an AUC of 0.83 (95% CI 0.76-0.89) versus 0.76 (95% CI 0.67-0.85) for hscTnT (P= 0.096). A GDF-15 cutoff of <= 886 ng/L predicted 2-year survival in 37% (203/556) of non-AMI patients and had 100% sensitivity (95% CI 86-100%) for 2-year death. Conclusions: GDF-15 concentrations at emergency department presentation have a high predictive accuracy for all-cause death in patients with suspected AMI and allow the identification of a large proportion of AMI patients with very low mortality risk. (C) 2019 Elsevier B.V. All rights reserved.
ER  -

WALTER, Joan, Thomas NESTELBERGER, Jasper BOEDDINGHAUS, Raphael TWERENBOLD, Lukas CROTON, Patrick BADERTSCHER, Karin WILDI, Desiree WUSSLER, Jeanne du Fay DE LAVALLAZ, Christian MUELLER, Maria Rubini GIMENEZ, Christian PUELACHER, Nikola KOZHUHAROV, Beata MORAWIEC, Katharina RENTSCH, Oscar MIRO, F. Javier MARTIN-SANCHEZ, Piotr MUZYK, Nicolas GEIGY, Dagmar I. KELLER, Tobias REICHLIN, Jens LOHRMANN, Ewalina BISKUP, Wanda KLOOS, Beatriz LOPEZ, Carolina Fuenzalida INOSTROZA, Esther Rodriguez ADRADA, Damian KAWECKI, Piotr MUZYK, Ewa NOWALANY-KOZIELSKA, Jiří PAŘENICA, Kathrin MEISSNER, Caroline KULANGARA, Riham MAHFOUZ, Katharina RENTSCH a Arnold VON ECKARDSTEIN. Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction. \textit{International Journal of Cardiology}. Clare: Elsevier Ireland Ltd., 2019, roč.~292, October, s.~241-245. ISSN~0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2019.04.088.

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