FOLTA, Adam, Martin ČULEN, Ivana JEŽÍŠKOVÁ, Zdeňka HERUDKOVÁ, Nikola TOM, Tereza HLUBINKOVÁ, Veronika JANEČKOVÁ, Anna ĎURINÍKOVÁ, Jan VYDRA, Lukáš SEMERÁD, Dana DVOŘÁKOVÁ, Hana REMEŠOVÁ, Ela CEROVSKÁ, Petr CETKOVSKÝ, Pavel JINDRA, Tomáš SZOTKOWSKI, Pavel ŽÁK, Jiří MAYER a Zdeněk RÁČIL. Prognostic significance of mutation profile at diagnosis and mutation persistence during disease remission in adult acute myeloid leukaemia patients. British journal of haematology. England: Wiley-Blackwell, 2019, roč. 186, č. 2, s. 300-310. ISSN 0007-1048. Dostupné z: https://dx.doi.org/10.1111/bjh.15916. |
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@article{1552216, author = {Folta, Adam and Čulen, Martin and Ježíšková, Ivana and Herudková, Zdeňka and Tom, Nikola and Hlubinková, Tereza and Janečková, Veronika and Ďuriníková, Anna and Vydra, Jan and Semerád, Lukáš and Dvořáková, Dana and Remešová, Hana and Cerovská, Ela and Cetkovský, Petr and Jindra, Pavel and Szotkowski, Tomáš and Žák, Pavel and Mayer, Jiří and Ráčil, Zdeněk}, article_location = {England}, article_number = {2}, doi = {http://dx.doi.org/10.1111/bjh.15916}, keywords = {acute myeloid leukaemia; next generation sequencing; persistent mutations; prognostic markers; survival}, language = {eng}, issn = {0007-1048}, journal = {British journal of haematology}, title = {Prognostic significance of mutation profile at diagnosis and mutation persistence during disease remission in adult acute myeloid leukaemia patients}, url = {http://dx.doi.org/10.1111/bjh.15916}, volume = {186}, year = {2019} }
TY - JOUR ID - 1552216 AU - Folta, Adam - Čulen, Martin - Ježíšková, Ivana - Herudková, Zdeňka - Tom, Nikola - Hlubinková, Tereza - Janečková, Veronika - Ďuriníková, Anna - Vydra, Jan - Semerád, Lukáš - Dvořáková, Dana - Remešová, Hana - Cerovská, Ela - Cetkovský, Petr - Jindra, Pavel - Szotkowski, Tomáš - Žák, Pavel - Mayer, Jiří - Ráčil, Zdeněk PY - 2019 TI - Prognostic significance of mutation profile at diagnosis and mutation persistence during disease remission in adult acute myeloid leukaemia patients JF - British journal of haematology VL - 186 IS - 2 SP - 300-310 EP - 300-310 PB - Wiley-Blackwell SN - 00071048 KW - acute myeloid leukaemia KW - next generation sequencing KW - persistent mutations KW - prognostic markers KW - survival UR - http://dx.doi.org/10.1111/bjh.15916 L2 - http://dx.doi.org/10.1111/bjh.15916 N2 - In this multi-centre study, we analysed the prognostic impact of mutations in 19 genes associated with myeloid malignancies in 258 newly diagnosed acute myeloid leukaemia patients (aged 19-70 years) undergoing intensive therapy. We identified five patient groups with different prognostic risks and different benefits from allogeneic hematopoietic stem cell transplantation (alloHSCT) within the intermediate cytogenetic risk group patients (n = 184). The most adverse prognosis was observed in patients with DNMT3A and FLT3-ITD co-mutation, whose survival could be significantly improved with alloHSCT. In contrast, the most favourable prognosis without any further benefit from alloHSCT was identified in patients with mutations in NPM1 or CEBPA, after exclusion of the unfavourable prognostic groups defined by mutations in DNMT3A, RUNX1 or genes from chromatin/spliceosome group. An additional analysis of 113 diagnosis-remission paired samples revealed that persistence of non-DNMT3A mutations (above 2% VAF) represented a further negative prognostic factor. The proposed model offers a possible molecular stratification and treatment guidance for intermediate cytogenetic risk group patients. ER -
FOLTA, Adam, Martin ČULEN, Ivana JEŽÍŠKOVÁ, Zdeňka HERUDKOVÁ, Nikola TOM, Tereza HLUBINKOVÁ, Veronika JANEČKOVÁ, Anna ĎURINÍKOVÁ, Jan VYDRA, Lukáš SEMERÁD, Dana DVOŘÁKOVÁ, Hana REMEŠOVÁ, Ela CEROVSKÁ, Petr CETKOVSKÝ, Pavel JINDRA, Tomáš SZOTKOWSKI, Pavel ŽÁK, Jiří MAYER a Zdeněk RÁČIL. Prognostic significance of mutation profile at diagnosis and mutation persistence during disease remission in adult acute myeloid leukaemia patients. \textit{British journal of haematology}. England: Wiley-Blackwell, 2019, roč.~186, č.~2, s.~300-310. ISSN~0007-1048. Dostupné z: https://dx.doi.org/10.1111/bjh.15916.
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