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@article{1553877, author = {Fiedorová, Kristýna and Radvanský, Matěj and Bosák, Juraj and Grombiříková, Hana and Němcová, Eva and Králíčková, Pavlina and Černochová, Michaela and Kotásková, Iva and Lexa, Matej and Litzman, Jiří and Šmajs, David and Freiberger, Tomáš}, article_location = {LAUSANNE}, article_number = {1914}, doi = {http://dx.doi.org/10.3389/fimmu.2019.01914}, keywords = {CVID; IgA; gut microbiota; gut microbiome; gut mycobiota; gut mycobiome; fungal microbiota; fungal microbiome}, language = {eng}, issn = {1664-3224}, journal = {Frontiers in Immunology}, title = {Bacterial but Not Fungal Gut Microbiota Alterations Are Associated With Common Variable Immunodeficiency (CVID) Phenotype}, url = {https://www.frontiersin.org/articles/10.3389/fimmu.2019.01914/full}, volume = {10}, year = {2019} }
TY - JOUR ID - 1553877 AU - Fiedorová, Kristýna - Radvanský, Matěj - Bosák, Juraj - Grombiříková, Hana - Němcová, Eva - Králíčková, Pavlina - Černochová, Michaela - Kotásková, Iva - Lexa, Matej - Litzman, Jiří - Šmajs, David - Freiberger, Tomáš PY - 2019 TI - Bacterial but Not Fungal Gut Microbiota Alterations Are Associated With Common Variable Immunodeficiency (CVID) Phenotype JF - Frontiers in Immunology VL - 10 IS - 1914 SP - 1-14 EP - 1-14 PB - FRONTIERS MEDIA SA SN - 16643224 KW - CVID KW - IgA KW - gut microbiota KW - gut microbiome KW - gut mycobiota KW - gut mycobiome KW - fungal microbiota KW - fungal microbiome UR - https://www.frontiersin.org/articles/10.3389/fimmu.2019.01914/full L2 - https://www.frontiersin.org/articles/10.3389/fimmu.2019.01914/full N2 - Common Variable Immunodeficiency (CVID) is the most frequent symptomatic immune disorder characterized by reduced serum immunoglobulins. Patients often suffer from infectious and serious non-infectious complications which impact their life tremendously. The monogenic cause has been revealed in a minority of patients so far, indicating the role of multiple genes and environmental factors in CVID etiology. Using 16S and ITS rRNA amplicon sequencing, we analyzed the bacterial and fungal gut microbiota, respectively, in a group of 55 participants constituting of CVID patients and matched healthy controls including 16 case-control pairs living in the same household, to explore possible associations between gut microbiota composition and disease phenotype. We revealed less diverse and significantly altered bacterial but not fungal gut microbiota in CVID patients, which additionally appeared to be associated with a more severe disease phenotype. The factor of sharing the same household impacted both bacterial and fungal microbiome data significantly, although not as strongly as CVID diagnosis in bacterial assessment. Overall, our results suggest that gut bacterial microbiota is altered in CVID patients and may be one of the missing environmental drivers contributing to some of the symptoms and disease severity. Paired samples serving as controls will provide a better resolution between disease-related dysbiosis and other environmental confounders in future studies. ER -
FIEDOROVÁ, Kristýna, Matěj RADVANSKÝ, Juraj BOSÁK, Hana GROMBIŘÍKOVÁ, Eva NĚMCOVÁ, Pavlina KRÁLÍČKOVÁ, Michaela ČERNOCHOVÁ, Iva KOTÁSKOVÁ, Matej LEXA, Jiří LITZMAN, David ŠMAJS a Tomáš FREIBERGER. Bacterial but Not Fungal Gut Microbiota Alterations Are Associated With Common Variable Immunodeficiency (CVID) Phenotype. \textit{Frontiers in Immunology}. LAUSANNE: FRONTIERS MEDIA SA, 2019, roč.~10, č.~1914, s.~1-14. ISSN~1664-3224. Dostupné z: https://dx.doi.org/10.3389/fimmu.2019.01914.
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