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@article{1556101,
author = {BolikandCoulon, N. and Cousin, A.F. and Kadeřávek, Pavel and Dumez, J.N. and Ferrage, F.},
article_location = {MELVILLE},
article_number = {22},
doi = {http://dx.doi.org/10.1063/1.5095757},
keywords = {MOLECULAR-WEIGHT PROTEINS; SIDE-CHAIN DYNAMICS; MODEL-FREE APPROACH; NMR-SPECTROSCOPY; RELAXATION; C-13; MACROMOLECULES; STRATEGIES; MOTIONS},
language = {eng},
issn = {0021-9606},
journal = {Journal of Chemical Physics},
title = {Understanding the methyl-TROSY effect over a wide range of magnetic fields},
url = {https://aip.scitation.org/doi/10.1063/1.5095757},
volume = {150},
year = {2019}
}
TY - JOUR
ID - 1556101
AU - Bolik-Coulon, N. - Cousin, A.F. - Kadeřávek, Pavel - Dumez, J.N. - Ferrage, F.
PY - 2019
TI - Understanding the methyl-TROSY effect over a wide range of magnetic fields
JF - Journal of Chemical Physics
VL - 150
IS - 22
SP - 224202
EP - 224202
PB - American Institute of Physics
SN - 00219606
KW - MOLECULAR-WEIGHT PROTEINS
KW - SIDE-CHAIN DYNAMICS
KW - MODEL-FREE APPROACH
KW - NMR-SPECTROSCOPY
KW - RELAXATION
KW - C-13
KW - MACROMOLECULES
KW - STRATEGIES
KW - MOTIONS
UR - https://aip.scitation.org/doi/10.1063/1.5095757
L2 - https://aip.scitation.org/doi/10.1063/1.5095757
N2 - The use of relaxation interference in the methyl Transverse Relaxation-Optimized SpectroscopY (TROSY) experiment has opened new avenues for the study of large proteins and protein assemblies in nuclear magnetic resonance. So far, the theoretical description of the methyl-TROSY experiment has been limited to the slow-tumbling approximation, which is correct for large proteins on high-field spectrometers. In a recent paper, favorable relaxation interference was observed in the methyl groups of a small protein at a magnetic field as low as 0.33 T, well outside the slow-tumbling regime. Here, we present a model to describe relaxation interference in methyl groups over a broad range of magnetic fields, not limited to the slow-tumbling regime. We predict that the type of multiple-quantum transition that shows favorable relaxation properties change with the magnetic field. Under the condition of fast methyl-group rotation, methyl-TROSY experiments can be recorded over the entire range of magnetic fields from a fraction of 1 T up to 100 T.
ER -
BOLIK-COULON, N., A.F. COUSIN, Pavel KADEŘÁVEK, J.N. DUMEZ a F. FERRAGE. Understanding the methyl-TROSY effect over a wide range of magnetic fields. \textit{Journal of Chemical Physics}. MELVILLE: American Institute of Physics, 2019, roč.~150, č.~22, s.~224202-224213. ISSN~0021-9606. Dostupné z: https://dx.doi.org/10.1063/1.5095757.
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