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@proceedings{1558936,
author = {Drabinová, Martina and Čarnecká, Martina and Humpa, Otakar and Slaninová, Iva and Slanina, Jiří},
booktitle = {20. ročník Školy hmotnostní spektrometrie},
keywords = {liquid chromatography; mass spectrometry; lignans; bioactivity; isomerism; Schizandra},
language = {eng},
isbn = {978-80-88195-14-6},
title = {SYNTHESIS AND EVALUATION OF ACETYL DERIVATIVES OF DIBENZOCYCLOOCTADIENE LIGNANS AS P-GLYCOPROTEIN INHIBITORS},
url = {http://www.skolams.cz/},
year = {2019}
}
TY - CONF
ID - 1558936
AU - Drabinová, Martina - Čarnecká, Martina - Humpa, Otakar - Slaninová, Iva - Slanina, Jiří
PY - 2019
TI - SYNTHESIS AND EVALUATION OF ACETYL DERIVATIVES OF DIBENZOCYCLOOCTADIENE LIGNANS AS P-GLYCOPROTEIN INHIBITORS
SN - 9788088195146
KW - liquid chromatography
KW - mass spectrometry
KW - lignans
KW - bioactivity
KW - isomerism
KW - Schizandra
UR - http://www.skolams.cz/
L2 - http://www.skolams.cz/
N2 - P-glycoprotein is typical ATP binding cassette (ABC) transporter responsible for the transportation out of cells of various xenobiotics including cytostatic compounds. A possible method for overcoming the resistance to anticancer drugs is the coadministration of compounds showing low toxicity and an ability to inhibit ABC transporters. Promising inhibitory activity has been discovered group of plant phenols, the dibenzocyclooctadiene lignans, from two plant genera Schisandra and Kadsura. The main source of these lignans are the fruits of Schisandra chinensis. In previous works three main structural features of dibenzocyclooctadiene lignans involved in P-glycoprotein inhibition were revealed: a 1,2,3-trimethoxy moiety, a 6- acyloxy group, and the absence of a 7-hydroxy group. To prepare more active derivatives, 7-hydroxy group was modified by acetylation.
ER -
DRABINOVÁ, Martina, Martina ČARNECKÁ, Otakar HUMPA, Iva SLANINOVÁ a Jiří SLANINA. SYNTHESIS AND EVALUATION OF ACETYL DERIVATIVES OF DIBENZOCYCLOOCTADIENE LIGNANS AS P-GLYCOPROTEIN INHIBITORS. In \textit{20. ročník Školy hmotnostní spektrometrie}. 2019. ISBN~978-80-88195-14-6.
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