Holocaust history is not reflected in telomere homeostasis in
survivors and their offspring

J 2019

Holocaust history is not reflected in telomere homeostasis in survivors and their offspring

KONEČNÁ, Klára, Martin LYČKA, Lucie NOHELOVÁ, Monika PETRÁKOVÁ, Monika FŇAŠKOVÁ et. al.

Základní údaje

Originální název

Holocaust history is not reflected in telomere homeostasis in survivors and their offspring

Autoři

KONEČNÁ, Klára (203 Česká republika, domácí), Martin LYČKA (203 Česká republika, domácí), Lucie NOHELOVÁ (203 Česká republika, domácí), Monika PETRÁKOVÁ (203 Česká republika, domácí), Monika FŇAŠKOVÁ (203 Česká republika, domácí), Eva KORIŤÁKOVÁ (203 Česká republika, domácí), Pavla SOVÁKOVÁ (203 Česká republika, domácí), Sylva BRABENCOVÁ (203 Česká republika, domácí), Marek PREISS (203 Česká republika, domácí), Ivan REKTOR (203 Česká republika, domácí), Jiří FAJKUS (203 Česká republika, domácí) a Miloslava FOJTOVÁ (203 Česká republika, garant, domácí)

Vydání

Journal of Psychiatric Research, Elsevier, 2019, 0022-3956

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30101 Human genetics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Stránka publikace na PubMed

Impakt faktor

Impact factor: 3.745

Kód RIV

RIV/00216224:14740/19:00108514

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.jpsychires.2019.06.018

UT WoS

000484872500002

Klíčová slova anglicky

Telomere; Holocaust; stress; quantitative PCR

Štítky

14119612, holocaust, podil, rivok, telomere

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 6. 2022 11:34, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Telomeres, nucleoprotein structures at the ends of eukaryotic chromosomes, are crucial for the maintenance of genome integrity. While the lengths of telomeres at birth are determined genetically, many factors including environmental and living conditions affect the telomere lengths during a lifespan. In this context, extreme and long-term stress has been shown to negatively impact telomeres and their protective function, with even offspring being influenced by the stress experienced by parents. Using quantitative PCR, the relative lengths of telomeres of survivors of the Holocaust during World War II and two generations of their offspring were analyzed. These data were related to those of control groups, persons of comparable age without a strong life stress experience. In contrast to previous studies of other stress-exposed groups, the relative lengths of telomeres were comparable in groups of persons exposed to Holocaust-related stress and their progenies, and in control groups. Interestingly, shorter telomeres of Holocaust survivors of the age under 12 in the year 1945 compared to Holocaust survivors of the age above 12 were detected. Our results are discussed with respect to certain exceptionality of persons having been able to cope with an extreme stress more than 70 years ago and living to a very old age.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NV18-04-00559, projekt VaV

Název: Neurobiologické a psychologické markery reakce na extrémní stres a jeho dopad na potomky - třígenerační studie přeživších holokaust a jejich potomků

Investor: Ministerstvo zdravotnictví ČR, Neurobiologické a psychologické markery reakce na extrémní stres a dopad na generace potomků - třígenerační studie přeživších holokaust a jejich potomků

Citovat

KONEČNÁ, Klára, Martin LYČKA, Lucie NOHELOVÁ, Monika PETRÁKOVÁ, Monika FŇAŠKOVÁ, Eva KORIŤÁKOVÁ, Pavla SOVÁKOVÁ, Sylva BRABENCOVÁ, Marek PREISS, Ivan REKTOR, Jiří FAJKUS a Miloslava FOJTOVÁ. Holocaust history is not reflected in telomere homeostasis in survivors and their offspring. Journal of Psychiatric Research. Elsevier, 2019, roč. 117, OCT 2019, s. 7-14. ISSN 0022-3956. Dostupné z: https://dx.doi.org/10.1016/j.jpsychires.2019.06.018.

@article{1561417,
   author = {Konečná, Klára and Lyčka, Martin and Nohelová, Lucie and Petráková, Monika and Fňašková, Monika and Koriťáková, Eva and Sováková, Pavla and Brabencová, Sylva and Preiss, Marek and Rektor, Ivan and Fajkus, Jiří and Fojtová, Miloslava},
   article_number = {OCT 2019},
   doi = {http://dx.doi.org/10.1016/j.jpsychires.2019.06.018},
   keywords = {Telomere; Holocaust; stress; quantitative PCR},
   language = {eng},
   issn = {0022-3956},
   journal = {Journal of Psychiatric Research},
   title = {Holocaust history is not reflected in telomere homeostasis in survivors and their offspring},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/31255955},
   volume = {117},
   year = {2019}
}

TY  - JOUR
ID  - 1561417
AU  - Konečná, Klára - Lyčka, Martin - Nohelová, Lucie - Petráková, Monika - Fňašková, Monika - Koriťáková, Eva - Sováková, Pavla - Brabencová, Sylva - Preiss, Marek - Rektor, Ivan - Fajkus, Jiří - Fojtová, Miloslava
PY  - 2019
TI  - Holocaust history is not reflected in telomere homeostasis in survivors and their offspring
JF  - Journal of Psychiatric Research
VL  - 117
IS  - OCT 2019
SP  - 7-14
EP  - 7-14
PB  - Elsevier
SN  - 00223956
KW  - Telomere
KW  - Holocaust
KW  - stress
KW  - quantitative PCR
UR  - http://www.ncbi.nlm.nih.gov/pubmed/31255955
L2  - http://www.ncbi.nlm.nih.gov/pubmed/31255955
N2  - Telomeres, nucleoprotein structures at the ends of eukaryotic chromosomes, are crucial for the maintenance of genome integrity. While the lengths of telomeres at birth are determined genetically, many factors including environmental and living conditions affect the telomere lengths during a lifespan. In this context, extreme and long-term stress has been shown to negatively impact telomeres and their protective function, with even offspring being influenced by the stress experienced by parents. Using quantitative PCR, the relative lengths of telomeres of survivors of the Holocaust during World War II and two generations of their offspring were analyzed. These data were related to those of control groups, persons of comparable age without a strong life stress experience. In contrast to previous studies of other stress-exposed groups, the relative lengths of telomeres were comparable in groups of persons exposed to Holocaust-related stress and their progenies, and in control groups. Interestingly, shorter telomeres of Holocaust survivors of the age under 12 in the year 1945 compared to Holocaust survivors of the age above 12 were detected. Our results are discussed with respect to certain exceptionality of persons having been able to cope with an extreme stress more than 70 years ago and living to a very old age.
ER  -

KONEČNÁ, Klára, Martin LYČKA, Lucie NOHELOVÁ, Monika PETRÁKOVÁ, Monika FŇAŠKOVÁ, Eva KORIŤÁKOVÁ, Pavla SOVÁKOVÁ, Sylva BRABENCOVÁ, Marek PREISS, Ivan REKTOR, Jiří FAJKUS a Miloslava FOJTOVÁ. Holocaust history is not reflected in telomere homeostasis in survivors and their offspring. \textit{Journal of Psychiatric Research}. Elsevier, 2019, roč.~117, OCT 2019, s.~7-14. ISSN~0022-3956. Dostupné z: https://dx.doi.org/10.1016/j.jpsychires.2019.06.018.

Podrobný výpis o publikaci