The Pathosome: A Dynamic Three-Dimensional View of
Disease-Environment Interaction

J 2019

The Pathosome: A Dynamic Three-Dimensional View of Disease-Environment Interaction

LENÁRT, Peter, Martin SCHERINGER a Julie DOBROVOLNÁ

Základní údaje

Originální název

The Pathosome: A Dynamic Three-Dimensional View of Disease-Environment Interaction

Autoři

LENÁRT, Peter (703 Slovensko, domácí), Martin SCHERINGER (756 Švýcarsko, domácí) a Julie DOBROVOLNÁ (203 Česká republika, garant, domácí)

Vydání

BIOESSAYS, HOBOKEN, WILEY, 2019, 0265-9247

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10602 Biology , Evolutionary biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Full Text

Impakt faktor

Impact factor: 4.631

Kód RIV

RIV/00216224:14310/19:00110768

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1002/bies.201900014

UT WoS

000474783900008

Klíčová slova anglicky

disease; environment; health; pathosome; phenotype; preconditioning

Štítky

14110518, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 3. 2020 14:32, Mgr. Marie Šípková, DiS.

Anotace

V originále

Most contemporary models of disease development consider the interaction between genotype and environment as static. The authors argue that because time is a key factor in genotype-environment interaction, this approach oversimplifies the pathology analysis and may lead to wrong conclusions. In reviewing the field, the authors suggest that the history of genotype-environment interactions plays an important role in the development of diseases and that this history may be analyzed using the phenotype as a proxy. Furthermore, a theoretical and experimental framework is proposed based on the assumption that phenotypes do not change from one to another randomly but are interconnected and follow certain phenotype trajectories. It then follows that analysis of such phenotype trajectories might be useful to predict the future phenotypes including the onset of disease. In addition, an analysis of phenotype trajectories can be subsequently used to choose better control subjects in comparative studies reducing noise and bias in studies investigating disease mechanisms.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF16_013/0001761, projekt VaV

Název: RECETOX RI

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

MUNI/A/1553/2018, interní kód MU

Název: Genetické, environmentální a tkáňové charakteristiky vybraných patologických stavů a nemocí (Akronym: genetika; stres; biomateriály; tkáňové kultury)

Investor: Masarykova univerzita, Genetické, environmentální a tkáňové charakteristiky vybraných patologických stavů a nemocí, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

LENÁRT, Peter, Martin SCHERINGER a Julie DOBROVOLNÁ. The Pathosome: A Dynamic Three-Dimensional View of Disease-Environment Interaction. BIOESSAYS. HOBOKEN: WILEY, 2019, roč. 41, č. 6, s. 1-6. ISSN 0265-9247. Dostupné z: https://dx.doi.org/10.1002/bies.201900014.

@article{1561636,
   author = {Lenárt, Peter and Scheringer, Martin and Dobrovolná, Julie},
   article_location = {HOBOKEN},
   article_number = {6},
   doi = {http://dx.doi.org/10.1002/bies.201900014},
   keywords = {disease; environment; health; pathosome; phenotype; preconditioning},
   language = {eng},
   issn = {0265-9247},
   journal = {BIOESSAYS},
   title = {The Pathosome: A Dynamic Three-Dimensional View of Disease-Environment Interaction},
   url = {https://onlinelibrary.wiley.com/doi/full/10.1002/bies.201900014},
   volume = {41},
   year = {2019}
}

TY  - JOUR
ID  - 1561636
AU  - Lenárt, Peter - Scheringer, Martin - Dobrovolná, Julie
PY  - 2019
TI  - The Pathosome: A Dynamic Three-Dimensional View of Disease-Environment Interaction
JF  - BIOESSAYS
VL  - 41
IS  - 6
SP  - 1-6
EP  - 1-6
PB  - WILEY
SN  - 02659247
KW  - disease
KW  - environment
KW  - health
KW  - pathosome
KW  - phenotype
KW  - preconditioning
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/bies.201900014
L2  - https://onlinelibrary.wiley.com/doi/full/10.1002/bies.201900014
N2  - Most contemporary models of disease development consider the interaction between genotype and environment as static. The authors argue that because time is a key factor in genotype-environment interaction, this approach oversimplifies the pathology analysis and may lead to wrong conclusions. In reviewing the field, the authors suggest that the history of genotype-environment interactions plays an important role in the development of diseases and that this history may be analyzed using the phenotype as a proxy. Furthermore, a theoretical and experimental framework is proposed based on the assumption that phenotypes do not change from one to another randomly but are interconnected and follow certain phenotype trajectories. It then follows that analysis of such phenotype trajectories might be useful to predict the future phenotypes including the onset of disease. In addition, an analysis of phenotype trajectories can be subsequently used to choose better control subjects in comparative studies reducing noise and bias in studies investigating disease mechanisms.
ER  -

LENÁRT, Peter, Martin SCHERINGER a Julie DOBROVOLNÁ. The Pathosome: A Dynamic Three-Dimensional View of Disease-Environment Interaction. \textit{BIOESSAYS}. HOBOKEN: WILEY, 2019, roč.~41, č.~6, s.~1-6. ISSN~0265-9247. Dostupné z: https://dx.doi.org/10.1002/bies.201900014.

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