What can egg-proteases tell us about the pathogenesis caused by
trematodes?

a 2019

What can egg-proteases tell us about the pathogenesis caused by trematodes?

RESLOVÁ, Nikol, Lucie ŠKORPÍKOVÁ, Jana ILGOVÁ, Pavel ROUDNICKÝ, Jiří VOREL et. al.

Základní údaje

Originální název

What can egg-proteases tell us about the pathogenesis caused by trematodes?

Autoři

RESLOVÁ, Nikol, Lucie ŠKORPÍKOVÁ, Jana ILGOVÁ, Pavel ROUDNICKÝ, Jiří VOREL a Martin KAŠNÝ

Vydání

JOINT COMBAR –ACSRPC MEETING: Anthelmintic resistance in ruminants:Who cares? 2019

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Stát vydavatele

Belgie

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

Fasciola hepatica, Schistosoma mansoni, exkrečně-sekreční produkty ve vajíčkách, proteázy

Klíčová slova anglicky

Fasciola hepatica, Schistosoma mansoni, excretory-secretory products of eggs, proteases

Změněno: 30. 9. 2019 10:11, Mgr. Lucie Škorpíková, Ph.D.

Anotace

V originále

Eggs released by female schistosomes are considered to be the primary cause of symptoms connected with schistosomiasis. Discharge of molecules (mainly proteases) by eggs facilitate their migration through the tissue of the host. Nevertheless, as a side-effect they cause severe pathogenesis manifested by inflammation, granuloma formation and subsequent fibrosis of the tissue. The eggs of Fasciola hepatica, trematode which inhabits the bile ducts of number of ruminants and other vertebrate species, are not supposed to have such detrimental effects on its host although the eggs related proteolytic activity was recorded. The detailed protein composition of F. hepaticaeggs ́ products remains unrevealed. Comparison of proteins from the excretory-secretory products of eggs from highly pathogenic vs. non-pathogenic species could represent a step towards better understanding of biology of F. hepatica, pathogenesis associated with S. mansoni infections and thus contribute to effective drug treatment. In our newly launched scientific project we aim to compare proteolytic cocktails present in E/S products ofS.mansoniand F. hepatica eggs. We focus particularly on the identification of proteases by functional proteomics, evaluation of their physiological role by genomic studies, and their recombinant expression and biochemical characterization.

Návaznosti

GA19-17269S, projekt VaV

Název: Proteolýza ve vejcích parazitických červů: úloha v patologii a její regulace (Akronym: Proteolýza vajec červů)

Investor: Grantová agentura ČR, Proteolýza ve vejcích parazitických červů: úloha v patologii a její regulace

MUNI/A/0918/2018, interní kód MU

Název: Studium evolučních a ekologických vztahů a procesů u akvatických bezobratlých živočichů a v hostitelsko-parazitických systémech (Akronym: EvolEcolParaHydro)

Investor: Masarykova univerzita, Studium evolučních a ekologických vztahů a procesů u akvatických bezobratlých živočichů a v hostitelsko-parazitických systémech, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

RESLOVÁ, Nikol, Lucie ŠKORPÍKOVÁ, Jana ILGOVÁ, Pavel ROUDNICKÝ, Jiří VOREL a Martin KAŠNÝ. What can egg-proteases tell us about the pathogenesis caused by trematodes? In JOINT COMBAR –ACSRPC MEETING: Anthelmintic resistance in ruminants:Who cares? 2019.

@proceedings{1564177,
   author = {Reslová, Nikol and Škorpíková, Lucie and Ilgová, Jana and Roudnický, Pavel and Vorel, Jiří and Kašný, Martin},
   booktitle = {JOINT COMBAR –ACSRPC MEETING: Anthelmintic resistance in ruminants:Who cares?},
   keywords = {Fasciola hepatica, Schistosoma mansoni, excretory-secretory products of eggs, proteases},
   language = {eng},
   title = {What can egg-proteases tell us about the pathogenesis caused by trematodes?},
   year = {2019}
}

TY  - CONF
ID  - 1564177
AU  - Reslová, Nikol - Škorpíková, Lucie - Ilgová, Jana - Roudnický, Pavel - Vorel, Jiří - Kašný, Martin
PY  - 2019
TI  - What can egg-proteases tell us about the pathogenesis caused by trematodes?
KW  - Fasciola hepatica, Schistosoma mansoni, excretory-secretory products of eggs, proteases
N2  - Eggs released by female schistosomes are considered to be the primary cause of symptoms connected with schistosomiasis. Discharge of molecules (mainly proteases) by eggs facilitate their migration through the tissue of the host. Nevertheless, as a side-effect they cause severe pathogenesis manifested by inflammation, granuloma formation and subsequent fibrosis of the tissue. The eggs of Fasciola hepatica, trematode which inhabits the bile ducts of number of ruminants and other vertebrate species, are not supposed to have such detrimental effects on its host although the eggs related proteolytic activity was recorded. The detailed protein composition of F. hepaticaeggs ́ products remains unrevealed. Comparison of proteins from the excretory-secretory products of eggs from highly pathogenic vs. non-pathogenic species could represent a step towards better understanding of biology of F. hepatica, pathogenesis associated with S. mansoni infections and thus contribute to effective drug treatment. In our newly launched scientific project we aim to compare proteolytic cocktails present in E/S products ofS.mansoniand F. hepatica eggs. We focus particularly on the identification of proteases by functional proteomics, evaluation of their physiological role by genomic studies, and their recombinant expression and biochemical characterization.
ER  -

RESLOVÁ, Nikol, Lucie ŠKORPÍKOVÁ, Jana ILGOVÁ, Pavel ROUDNICKÝ, Jiří VOREL a Martin KAŠNÝ. What can egg-proteases tell us about the pathogenesis caused by trematodes? In \textit{JOINT COMBAR –ACSRPC MEETING: Anthelmintic resistance in ruminants:Who cares?}. 2019.

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