a 2019

Simulation of the biliary metal stent recanalisation using endoluminal irreversible electroporation on porcine liver - in vivo experiment

ROHAN, Tomáš, Tomáš ANDRAŠINA, Peter MATKULČÍK, Tomáš JŮZA, Jan ZAVADIL et. al.

Basic information

Original name

Simulation of the biliary metal stent recanalisation using endoluminal irreversible electroporation on porcine liver - in vivo experiment

Authors

ROHAN, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Tomáš ANDRAŠINA (703 Slovakia, belonging to the institution), Peter MATKULČÍK (703 Slovakia, belonging to the institution), Tomáš JŮZA (203 Czech Republic, belonging to the institution), Jan ZAVADIL (203 Czech Republic, belonging to the institution), Iva SVOBODOVÁ (203 Czech Republic, belonging to the institution), Dalibor ČERVINKA (203 Czech Republic) and Vlastimil VÁLEK (203 Czech Republic, belonging to the institution)

Edition

CIRSE 2019, 2019

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30224 Radiology, nuclear medicine and medical imaging

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.034

RIV identification code

RIV/00216224:14110/19:00110835

Organization unit

Faculty of Medicine

ISSN

DOI

Keywords in English

biliary intervention; stent recanalisation; irreversible electroporation

Tags

Tags

International impact
Změněno: 21/4/2020 11:08, Mgr. Tereza Miškechová

Abstract

V originále

Purpose: To demonstrate feasibility of endoluminal irreversible electroporation using tubular catheter in biliary metal stent for recanalisation. Material and methods: 25 simulations of metal stent obstruction on porcine liver in vivo were performed by liver lower edge incision and its insertion in the biliary metal stent. In 14 cases endoluminal irreversible electroporation with tubular catheter prototype were performed, others were set as controls. Three diferent scenarios of IRE were simulated (one, two or zero electrodes in contact with metal stent). Ninety 100 us pulses with 300,650,1000 and 1300 Volts were used in each scenario. Electrical parameters, macroscopical changes, side efects were monitored during the procedure. Early complications were evaluated by CT immediately and 72 hours after the procedure, followed by samples harvesting. Results: There were no complications detected during the procedure and on following CTs, enduluminal IRE was succesful in all cases. Signifcant diference in impedance was observed between all scenario settings (p=0,02, Mann-Whitey). Short circuit occured immediately in 1300 V in all scenarios, in both cases of 1000 V with one electrode in contact with stent and in case where both electrodes were in contact with stent. The highest observed safe voltage for IRE in metal stent was 850 V/cm. Histopathological analysis showed signs of tissue necrosis which were not present in control samples. Conclusion: Endoluminal irreversible electroporation using tubular catheter seems safe and feasible method and has potential for non-thermal metal stent ingrowth treatment.

Links

MUNI/A/0996/2018, interní kód MU
Name: Infrared thermal imaging – neinvazivní zobrazovací metoda s využitím v klinickém prostředí (Acronym: IRT)
Investor: Masaryk University, Category A
MUNI/A/1574/2018, interní kód MU
Name: Onkologické radiologické intervence a jejich přínos v rámci komplexní onkologické léčby, srovnání s celorepublikovými výsledky onkologické léčby vybraných diagnóz II
Investor: Masaryk University, Category A