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@article{1567016,
author = {Andršová, Irena and Hnatkova, Katerina and Helánová, Kateřina and Šišáková, Martina and Novotný, Tomáš and Kala, Petr and Malik, Marek},
article_location = {Lausanne},
article_number = {AUG 2 2019},
doi = {http://dx.doi.org/10.3389/fphys.2019.00994},
keywords = {age; sex differences; individual QT/RR patterns; QT/RR hysteresis; QTc interval; QT/RR slope},
language = {eng},
issn = {1664-042X},
journal = {Frontiers in Physiology},
title = {Individually Rate Corrected QTc Intervals in Children and Adolescents},
url = {http://dx.doi.org/10.3389/fphys.2019.00994},
volume = {10},
year = {2019}
}
TY - JOUR
ID - 1567016
AU - Andršová, Irena - Hnatkova, Katerina - Helánová, Kateřina - Šišáková, Martina - Novotný, Tomáš - Kala, Petr - Malik, Marek
PY - 2019
TI - Individually Rate Corrected QTc Intervals in Children and Adolescents
JF - Frontiers in Physiology
VL - 10
IS - AUG 2 2019
SP - 1-15
EP - 1-15
PB - Frontiers Media
SN - 1664042X
KW - age
KW - sex differences
KW - individual QT/RR patterns
KW - QT/RR hysteresis
KW - QTc interval
KW - QT/RR slope
UR - http://dx.doi.org/10.3389/fphys.2019.00994
L2 - http://dx.doi.org/10.3389/fphys.2019.00994
N2 - Accurate evaluation of the appearance of QTc sex differences during childhood and adolescence is intricate. Inter-subject differences of individual QT/RR patterns make generic heart rate corrections inaccurate because of fast resting heart rates in children. The study investigated 527 healthy children and adolescents aged 419 years (268 females, 50.9%). All underwent continuous ECG 12-lead monitoring while performing postural changes during a 70-min investigative protocol to obtain QT interval measurements at different heart rates. On average, more than 1200 ECG measurements (QT interval and its 5-min history of preceding RR intervals) were made in each subject. Curvilinear QT/RR regression involving intra-individual correction for QT/RR hysteresis were calculated in each subject. The projection of the QT/RR regressions to the heart rate of 60 beats per minute defined individually corrected QTc intervals. In males, gradual QTc shortening by about 15 ms appeared during the ages of 13-19 years synchronously with the incidence of secondary sex signs (p = 0.016). On the contrary, whilst gradual QTc prolongation by about 10 ms appeared in females, it occurred only during ages 16-19 years and was not related to the incidence of secondary sex signs (p = 0.18). The study also showed that in children and adolescents, linear QT/RR models fit the intra-subject data significantly more closely than the log-linear models (p < 0.001). The study speculates that hormonal shifts during puberty might be directly responsible for the QTc shortening in males but that QTc prolongation in females is likely more complex since it was noted to follow the appearance of secondary sex signs only after a considerable delay.
ER -
ANDRŠOVÁ, Irena, Katerina HNATKOVA, Kateřina HELÁNOVÁ, Martina ŠIŠÁKOVÁ, Tomáš NOVOTNÝ, Petr KALA a Marek MALIK. Individually Rate Corrected QTc Intervals in Children and Adolescents. \textit{Frontiers in Physiology}. Lausanne: Frontiers Media, 2019, roč.~10, AUG 2 2019, s.~1-15. ISSN~1664-042X. Dostupné z: https://dx.doi.org/10.3389/fphys.2019.00994.
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