The serum protease network-one key to understand complex
regional pain syndrome pathophysiology

J 2019

The serum protease network-one key to understand complex regional pain syndrome pathophysiology

KONIG, Simone, Malte BAYER, Violeta DIMOVA, Myriam HERRNBERGER, Fabiola ESCOLANO-LOZANO et. al.

Základní údaje

Originální název

The serum protease network-one key to understand complex regional pain syndrome pathophysiology

Autoři

KONIG, Simone (276 Německo), Malte BAYER (276 Německo), Violeta DIMOVA (276 Německo), Myriam HERRNBERGER (276 Německo), Fabiola ESCOLANO-LOZANO (276 Německo), Josef BEDNAŘÍK (203 Česká republika, garant, domácí), Eva VLČKOVÁ (203 Česká republika, domácí), Heike RITTNER (276 Německo), Tanja SCHLERETH (276 Německo) a Frank BIRKLEIN (276 Německo)

Vydání

Pain : the journal of the international association for the study of pain. New York, Elsevier, 2019, 0304-3959

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.483

Kód RIV

RIV/00216224:14110/19:00110899

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1097/j.pain.0000000000001503

UT WoS

000480762400015

Klíčová slova anglicky

Complex regional pain syndrome; Chronic pain; Bradykinin; Serum peptidase

Štítky

14110221, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 3. 2020 22:14, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Complex regional pain syndrome (CRPS) develops after fracture. The acute CRPS phenotype resembles exaggerated inflammation, which is explained by local and systemic activation of a proinflammatory network including peptides and cytokines. Epidemiologic data suggest that inactivation of the peptidase angiotensin-converting enzyme in patients treated for hypertension increases the odds to develop CRPS. This hint leads us to investigate the serum protease network activity in patients with CRPS vs respective controls. For this purpose, we developed a dabsyl-bradykinin (DBK)-based assay and used it to investigate patients with CRPS, as well as healthy and pain (painful diabetic neuropathy [dPNP]) controls. The major result is that the degradation of DBK to fragments 1-8 and 1-5 in healthy control and dPNP is shifted to higher values for DBK1-8 and lower values for DBK1-5 at 1 hour of incubation in patients with CRPS. Using this novel reporter peptide assay, we have been able to show that the resolving protease network for mediators such as BK might be different in patients with CRPS; having a look at the clinical signs, which resemble inflammation, this resolving protease network is probably less effective in CRPS.

Návaznosti

MUNI/A/1419/2018, interní kód MU

Název: Diagnostika a patofyziologie neuropatické bolesti (Akronym: PNB)

Investor: Masarykova univerzita, Diagnostika a patofyziologie neuropatické bolesti, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

602133, interní kód MU

Název: ncRNAPain - Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (Akronym: ncRNAPain)

Investor: Evropská unie, ncRNAPain - Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine, Spolupráce

Citovat

KONIG, Simone, Malte BAYER, Violeta DIMOVA, Myriam HERRNBERGER, Fabiola ESCOLANO-LOZANO, Josef BEDNAŘÍK, Eva VLČKOVÁ, Heike RITTNER, Tanja SCHLERETH a Frank BIRKLEIN. The serum protease network-one key to understand complex regional pain syndrome pathophysiology. Pain : the journal of the international association for the study of pain. New York: Elsevier, 2019, roč. 160, č. 6, s. 1402-1409. ISSN 0304-3959. Dostupné z: https://dx.doi.org/10.1097/j.pain.0000000000001503.

@article{1567478,
   author = {Konig, Simone and Bayer, Malte and Dimova, Violeta and Herrnberger, Myriam and EscolanoandLozano, Fabiola and Bednařík, Josef and Vlčková, Eva and Rittner, Heike and Schlereth, Tanja and Birklein, Frank},
   article_location = {New York},
   article_number = {6},
   doi = {http://dx.doi.org/10.1097/j.pain.0000000000001503},
   keywords = {Complex regional pain syndrome; Chronic pain; Bradykinin; Serum peptidase},
   language = {eng},
   issn = {0304-3959},
   journal = {Pain : the journal of the international association for the study of pain.},
   title = {The serum protease network-one key to understand complex regional pain syndrome pathophysiology},
   url = {http://dx.doi.org/10.1097/j.pain.0000000000001503},
   volume = {160},
   year = {2019}
}

TY  - JOUR
ID  - 1567478
AU  - Konig, Simone - Bayer, Malte - Dimova, Violeta - Herrnberger, Myriam - Escolano-Lozano, Fabiola - Bednařík, Josef - Vlčková, Eva - Rittner, Heike - Schlereth, Tanja - Birklein, Frank
PY  - 2019
TI  - The serum protease network-one key to understand complex regional pain syndrome pathophysiology
JF  - Pain : the journal of the international association for the study of pain.
VL  - 160
IS  - 6
SP  - 1402-1409
EP  - 1402-1409
PB  - Elsevier
SN  - 03043959
KW  - Complex regional pain syndrome
KW  - Chronic pain
KW  - Bradykinin
KW  - Serum peptidase
UR  - http://dx.doi.org/10.1097/j.pain.0000000000001503
L2  - http://dx.doi.org/10.1097/j.pain.0000000000001503
N2  - Complex regional pain syndrome (CRPS) develops after fracture. The acute CRPS phenotype resembles exaggerated inflammation, which is explained by local and systemic activation of a proinflammatory network including peptides and cytokines. Epidemiologic data suggest that inactivation of the peptidase angiotensin-converting enzyme in patients treated for hypertension increases the odds to develop CRPS. This hint leads us to investigate the serum protease network activity in patients with CRPS vs respective controls. For this purpose, we developed a dabsyl-bradykinin (DBK)-based assay and used it to investigate patients with CRPS, as well as healthy and pain (painful diabetic neuropathy [dPNP]) controls. The major result is that the degradation of DBK to fragments 1-8 and 1-5 in healthy control and dPNP is shifted to higher values for DBK1-8 and lower values for DBK1-5 at 1 hour of incubation in patients with CRPS. Using this novel reporter peptide assay, we have been able to show that the resolving protease network for mediators such as BK might be different in patients with CRPS; having a look at the clinical signs, which resemble inflammation, this resolving protease network is probably less effective in CRPS.
ER  -

KONIG, Simone, Malte BAYER, Violeta DIMOVA, Myriam HERRNBERGER, Fabiola ESCOLANO-LOZANO, Josef BEDNAŘÍK, Eva VLČKOVÁ, Heike RITTNER, Tanja SCHLERETH a Frank BIRKLEIN. The serum protease network-one key to understand complex regional pain syndrome pathophysiology. \textit{Pain : the journal of the international association for the study of pain.}. New York: Elsevier, 2019, roč.~160, č.~6, s.~1402-1409. ISSN~0304-3959. Dostupné z: https://dx.doi.org/10.1097/j.pain.0000000000001503.

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