2019
The Sulfate-Reducing Microbial Communities and Meta-Analysis of Their Occurrence during Diseases of Small–Large Intestine Axis
KUSHKEVYCH, Ivan, Oľga LEŠČANOVÁ, Dani DORDEVIĆ, Simona JANČÍKOVÁ, Jan HOŠEK et. al.Základní údaje
Originální název
The Sulfate-Reducing Microbial Communities and Meta-Analysis of Their Occurrence during Diseases of Small–Large Intestine Axis
Autoři
KUSHKEVYCH, Ivan (804 Ukrajina, garant, domácí), Oľga LEŠČANOVÁ (703 Slovensko, domácí), Dani DORDEVIĆ (203 Česká republika), Simona JANČÍKOVÁ (203 Česká republika), Jan HOŠEK (203 Česká republika), Monika VÍTĚZOVÁ (203 Česká republika, domácí), Leona BUŇKOVÁ (203 Česká republika) a Lorenzo DRAGO (380 Itálie)
Vydání
Journal of Clinical Medicine, BASEL, MDPI, 2019, 2077-0383
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30219 Gastroenterology and hepatology
Stát vydavatele
Švýcarsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 3.303
Kód RIV
RIV/00216224:14310/19:00110934
Organizační jednotka
Přírodovědecká fakulta
UT WoS
000498398500154
Klíčová slova anglicky
bowel disease; colitis; small–large intestine axis; sulfate reduction; hydrogen sulfide
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 25. 3. 2020 11:47, Mgr. Marie Šípková, DiS.
Anotace
V originále
Sulfate-reducing bacteria (SRB) are often isolated from animals and people with ulcerative colitis and can be involved in the IBD development in the gut–intestine axis. The background of the research consisted of obtaining mixed cultures of SRB communities from healthy mice and mice with colitis, finding variation in the distribution of their morphology, to determine pH and temperature range tolerance and their possible production of hydrogen sulfide in the small–large intestinal environment. The methods: Microscopic techniques, biochemical, microbiological, and biophysical methods, and statistical processing of the results were used. The results: Variation in the distribution of sulfate-reducing microbial communities were detected. Mixed cultures from mice with ulcerative colitis had 1.39 times higher production of H2S in comparison with samples from healthy mice. The species of Desulfovibrio genus play an important role in diseases of the small–large intestine axis. Meta-analysis was also used for the observation about an SRB occurrence in healthy and not healthy individuals and the same as their metabolic processes. Conclusions: This finding is important for its possible correlation with inflammation of the intestine, where the present of SRB in high concentration plays a major part. It can be a good possible indicator of the occurrence of IBD.
Návaznosti
MUNI/A/0902/2018, interní kód MU |
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