MICHAL, Michael, Abbas AGAIMY, Andrew L. FOLPE, Iva STANICZKOVÁ ZAMBO, Radek KEBRLE, Raymund E. HORCH, Zdenek KINKOR, Marian SVAJDLER, Tomas VANECEK, Filip HEIDENREICH, Dmitry V. KAZAKOV, Kvetoslava MICHALOVA, Ladislav HADRAVSKY and Michal MICHAL. Tenosynovitis With Psammomatous Calcifications A Distinctive Trauma-Associated Subtype of Idiopathic Calcifying Tenosynovitis With a Predilection for the Distal extremities of Middle-Aged Women-A Report of 23 Cases. The American Journal of Surgical Pathology. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS, 2019, vol. 43, No 2, p. 261-267. ISSN 0147-5185. Available from: https://dx.doi.org/10.1097/PAS.0000000000001182.
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Basic information
Original name Tenosynovitis With Psammomatous Calcifications A Distinctive Trauma-Associated Subtype of Idiopathic Calcifying Tenosynovitis With a Predilection for the Distal extremities of Middle-Aged Women-A Report of 23 Cases
Authors MICHAL, Michael (203 Czech Republic, guarantor), Abbas AGAIMY (276 Germany), Andrew L. FOLPE (840 United States of America), Iva STANICZKOVÁ ZAMBO (203 Czech Republic, belonging to the institution), Radek KEBRLE (203 Czech Republic), Raymund E. HORCH (276 Germany), Zdenek KINKOR (203 Czech Republic), Marian SVAJDLER (203 Czech Republic), Tomas VANECEK (203 Czech Republic), Filip HEIDENREICH (203 Czech Republic), Dmitry V. KAZAKOV (203 Czech Republic), Kvetoslava MICHALOVA (203 Czech Republic), Ladislav HADRAVSKY (203 Czech Republic) and Michal MICHAL (203 Czech Republic).
Edition The American Journal of Surgical Pathology, PHILADELPHIA, LIPPINCOTT WILLIAMS & WILKINS, 2019, 0147-5185.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30109 Pathology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.958
RIV identification code RIV/00216224:14110/19:00111081
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1097/PAS.0000000000001182
UT WoS 000458401800014
Keywords in English tenosynovitis with psammomatous calcifications; idiopathic calcifying tenosynovitis; calcific periarthritis; calcifying tendinitis; tumoral calcinosis; psammoma bodies
Tags 14110112, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 29/10/2019 10:43.
Abstract
The term "idiopathic calcifying tenosynovitis" (ICT) refers to a clinically and radiologically defined syndrome of pain and tendinous calcifications, most often involving the shoulder joint. A distinctive subset of ICT cases, termed "tenosynovitis with psammomatous calcifications" (TPC), occurs in the distal extremities and shows characteristic morphology, in particular psammomatous calcifications. As only 14 cases have been reported to date, TPC remains poorly recognized by both pathologists and clinicians. Twenty-three well-characterized cases of TPC along with all available radiologic and clinical information, including follow-up, were collected. Cases occurred in 21 females and 1 male (1 patient of unknown sex), aged 16 to 75 years (mean: 41), and almost exclusively involved the fingers and toes, except for one case in the elbow and one in the knee joint. The lesions ranged from 2 to 30 mm in size (mean: 10 mm). Pain was the most common presenting symptom (12/16 patients). A history of trauma or repetitive activity was present in 6 of 15 patients. None of the individuals was known to have disorders in calcium or phosphate metabolism. Radiographic studies showed a nonspecific, calcified mass. Typical morphologic features of TPC were invariably present, with degenerating tendinous tissue containing psammomatous calcifications, surrounded by a variably cellular, CD68/CD163/CD4-positive histiocyte-rich granulomatous host reaction. HUMARA assay in one case showed a polyclonal pattern. Clinical follow-up (19 patients; mean: 5.2 y; range: 1 to 14 y) showed no local recurrences. In this, the largest study of TPC to date, we confirm striking predilection of this distinctive pseudoneoplasm for the fingers and toes of young to middle-aged women. TPC should be rigorously distinguished from other forms of ICT, which typically involve large, proximal joints, and show simply dystrophic calcification involving tendinous tissues, and from tumoral calcinosis, which also involves large joints and often is associated with calcium and/or phosphate abnormalities. TPC appears to be related to trauma and/or repetitive activity and is cured with simple excision.
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