The importance of complex karyotype in prognostication and
treatment of chronic lymphocytic leukemia (CLL): a
comprehensive review of the literature

J 2019

The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature

JAROŠOVÁ, Marie, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Michael DOUBEK, Šárka POSPÍŠILOVÁ et. al.

Základní údaje

Originální název

The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature

Autoři

JAROŠOVÁ, Marie (203 Česká republika, domácí), Karla PLEVOVÁ (203 Česká republika, domácí), Jana KOTAŠKOVÁ (203 Česká republika, domácí), Michael DOUBEK (203 Česká republika, domácí) a Šárka POSPÍŠILOVÁ (203 Česká republika, garant, domácí)

Vydání

LEUKEMIA & LYMPHOMA, LONDON, INFORMA HEALTHCARE, 2019, 1042-8194

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30205 Hematology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.969

Kód RIV

RIV/00216224:14740/19:00111112

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1080/10428194.2019.1576038

UT WoS

000489795900004

Klíčová slova anglicky

chromosomal aberrations; CLL; complex karyotype; FISH

Štítky

14110212, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 3. 2020 21:58, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Cytogenetic examination and the detection of chromosomal aberrations in chronic lymphocytic leukemia (CLL) is an integral part of prognostic stratification and treatment decisions. Improvements in cytogenetic methods, notably the introduction of the cell stimulation method, have led to the detection of chromosomal aberrations in 80% of CLL cases. A comprehensive analysis of cytogenetic aberrations recently showed that complex karyotypes (CKs) defined as the detection of either three or more or five or more chromosomal changes in a karyotype have a poor prognostic impact. The current efforts at the international level are focused on the goal of including CK assessment among prognostic markers for CLL patients at diagnosis as well as after treatment. This review of the literature documents the clinical importance of CK findings in CLL and the necessity of including this factor in other poor prognostic indicators.

Citovat

JAROŠOVÁ, Marie, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Michael DOUBEK a Šárka POSPÍŠILOVÁ. The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature. LEUKEMIA & LYMPHOMA. LONDON: INFORMA HEALTHCARE, 2019, roč. 60, č. 10, s. 2348-2355. ISSN 1042-8194. Dostupné z: https://dx.doi.org/10.1080/10428194.2019.1576038.

@article{1574782,
   author = {Jarošová, Marie and Plevová, Karla and Kotašková, Jana and Doubek, Michael and Pospíšilová, Šárka},
   article_location = {LONDON},
   article_number = {10},
   doi = {http://dx.doi.org/10.1080/10428194.2019.1576038},
   keywords = {chromosomal aberrations; CLL; complex karyotype; FISH},
   language = {eng},
   issn = {1042-8194},
   journal = {LEUKEMIA & LYMPHOMA},
   title = {The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature},
   url = {https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1576038},
   volume = {60},
   year = {2019}
}

TY  - JOUR
ID  - 1574782
AU  - Jarošová, Marie - Plevová, Karla - Kotašková, Jana - Doubek, Michael - Pospíšilová, Šárka
PY  - 2019
TI  - The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature
JF  - LEUKEMIA & LYMPHOMA
VL  - 60
IS  - 10
SP  - 2348-2355
EP  - 2348-2355
PB  - INFORMA HEALTHCARE
SN  - 10428194
KW  - chromosomal aberrations
KW  - CLL
KW  - complex karyotype
KW  - FISH
UR  - https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1576038
L2  - https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1576038
N2  - Cytogenetic examination and the detection of chromosomal aberrations in chronic lymphocytic leukemia (CLL) is an integral part of prognostic stratification and treatment decisions. Improvements in cytogenetic methods, notably the introduction of the cell stimulation method, have led to the detection of chromosomal aberrations in 80% of CLL cases. A comprehensive analysis of cytogenetic aberrations recently showed that complex karyotypes (CKs) defined as the detection of either three or more or five or more chromosomal changes in a karyotype have a poor prognostic impact. The current efforts at the international level are focused on the goal of including CK assessment among prognostic markers for CLL patients at diagnosis as well as after treatment. This review of the literature documents the clinical importance of CK findings in CLL and the necessity of including this factor in other poor prognostic indicators.
ER  -

JAROŠOVÁ, Marie, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Michael DOUBEK a Šárka POSPÍŠILOVÁ. The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature. \textit{LEUKEMIA \&{}amp; LYMPHOMA}. LONDON: INFORMA HEALTHCARE, 2019, roč.~60, č.~10, s.~2348-2355. ISSN~1042-8194. Dostupné z: https://dx.doi.org/10.1080/10428194.2019.1576038.

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