Different response of pulse wave velocity to orthostatic
challenge in older diabetics

a 2019

Different response of pulse wave velocity to orthostatic challenge in older diabetics

SVAČINOVÁ, Jana, Simona HIDEGOVÁ, Helena SIEGLOVÁ, Zuzana KAŠČÁKOVÁ, Martin FABŠÍK et. al.

Základní údaje

Originální název

Different response of pulse wave velocity to orthostatic challenge in older diabetics

Autoři

SVAČINOVÁ, Jana, Simona HIDEGOVÁ, Helena SIEGLOVÁ, Zuzana KAŠČÁKOVÁ, Martin FABŠÍK, Juraj JAKUBÍK, Jan NOVÁK, Zuzana NOVÁKOVÁ a Jana HRUŠKOVÁ

Vydání

Jahreskongress 2019, 2019

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

Změněno: 21. 4. 2020 18:07, Mgr. Bc. Jana Svačinová, Ph.D.

Anotace

V originále

Pulse wave velocity (PWV) increase is a marker of arterial stiffness. PWV increases with increased blood pressure (BP), due to endothelial dysfunction and structural changes of the arterial wall. Increased mean PWV is observed in diabetics as well as in hypertonics. Aim of this pilot study is analysis of arm and leg PWV in dependence of body position in diabetics and young healthy controls. PWV was measured in II. type diabetics (7m/8f, age 68±10 years, BP 158/90±19/9 mmHg) and healthy controls (5m/6f, age 23±2 years, BP 117/76±9/5 mmHg). PWV was recorded by method based on multichannel full body bioimpedance. Protocol consisted of 6 min of supine (sup) and 6 min of head up tilt in 45° (hut). PWV of left arm and left leg were measured. Results: Sup arm PWV was higher in diabetics than in controls regardless on posture. Hut increased leg PWV only in diabetics. Arm/leg PWV ratio vas significantly lower in diabetics during hut compared to controls. Hut/sup PWV ratio was increased in leg of diabetics compared to controls and arm. PWV in diabetics differ between arm and leg and it is significantly influenced by postural changes. Increased supine PWV in diabetics is a marker of increased arterial stiffness, both associated with aging and diabetes. Moreover PWV is directly increased by hypertension. Different response of arm/leg PWV to hut in diabetics is a sign of changed blood redistribution control. Increased hydrostatic pressure in the legs led to a PWV increase. Stronger PWV increase in diabetics suggests changes in endothelial function and autonomic system control over the arterial tonus, both responsible for blood redistribution. We suggest that arm/leg PWV ratio can be suitable parameter for the regular examination of the arterial function development in diabetics.

Návaznosti

MUNI/A/1255/2018, interní kód MU

Název: Kardiovaskulární systém a jeho regulace a dysregulace pod vlivem farmak (Akronym: KAREDYSFAR)

Investor: Masarykova univerzita, Kardiovaskulární systém a jeho regulace a dysregulace pod vlivem farmak, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/A/1475/2018, interní kód MU

Název: Diferenciální diagnostika a odhad prognózy interních nemocí 3 (Akronym: DIDIPRON 3)

Investor: Masarykova univerzita, Diferenciální diagnostika a odhad prognózy interních nemocí 3, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

SVAČINOVÁ, Jana, Simona HIDEGOVÁ, Helena SIEGLOVÁ, Zuzana KAŠČÁKOVÁ, Martin FABŠÍK, Juraj JAKUBÍK, Jan NOVÁK, Zuzana NOVÁKOVÁ a Jana HRUŠKOVÁ. Different response of pulse wave velocity to orthostatic challenge in older diabetics. In Jahreskongress 2019. 2019.

@proceedings{1584796,
   author = {Svačinová, Jana and Hidegová, Simona and Sieglová, Helena and Kaščáková, Zuzana and Fabšík, Martin and Jakubík, Juraj and Novák, Jan and Nováková, Zuzana and Hrušková, Jana},
   booktitle = {Jahreskongress 2019},
   language = {eng},
   title = {Different response of pulse wave velocity to orthostatic challenge in older diabetics},
   year = {2019}
}

TY  - CONF
ID  - 1584796
AU  - Svačinová, Jana - Hidegová, Simona - Sieglová, Helena - Kaščáková, Zuzana - Fabšík, Martin - Jakubík, Juraj - Novák, Jan - Nováková, Zuzana - Hrušková, Jana
PY  - 2019
TI  - Different response of pulse wave velocity to orthostatic challenge in older diabetics
N2  - Pulse wave velocity (PWV) increase is a marker of arterial stiffness. PWV increases with increased blood pressure (BP), due to endothelial dysfunction and structural changes of the arterial wall. Increased mean PWV is observed in diabetics as well as in hypertonics. Aim of this pilot study is analysis of arm and leg PWV in dependence of body position in diabetics and young healthy controls. PWV was measured in II. type diabetics (7m/8f, age 68±10 years, BP 158/90±19/9 mmHg) and healthy controls (5m/6f, age 23±2 years, BP 117/76±9/5 mmHg). PWV was recorded by method based on multichannel full body bioimpedance. Protocol consisted of 6 min of supine (sup) and 6 min of head up tilt in 45° (hut). PWV of left arm and left leg were measured. Results: Sup arm PWV was higher in diabetics than in controls regardless on posture. Hut increased leg PWV only in diabetics. Arm/leg PWV ratio vas significantly lower in diabetics during hut compared to controls. Hut/sup PWV ratio was increased in leg of diabetics compared to controls and arm. PWV in diabetics differ between arm and leg and it is significantly influenced by postural changes. Increased supine PWV in diabetics is a marker of increased arterial stiffness, both associated with aging and diabetes. Moreover PWV is directly increased by hypertension. Different response of arm/leg PWV to hut in diabetics is a sign of changed blood redistribution control. Increased hydrostatic pressure in the legs led to a PWV increase. Stronger PWV increase in diabetics suggests changes in endothelial function and autonomic system control over the arterial tonus, both responsible for blood redistribution. We suggest that arm/leg PWV ratio can be suitable parameter for the regular examination of the arterial function development in diabetics.
ER  -

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