| ACHBERGEROVA, E., D. SMEJKALOVA, G. HUERTA-ANGELES, Karel SOUČEK, M. HERMANNOVA, H. VAGNEROVA, R. VICHA and V. VELEBNY. In vivo monitoring of tumor distribution of hyaluronan polymeric micelles labeled or loaded with near-infrared fluorescence dye. Carbohydrate Polymers. Oxford: ELSEVIER SCI LTD, 2018, vol. 198, OCT, p. 339-347. ISSN 0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2018.06.082. |
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@article{1590296,
author = {Achbergerova, E. and Smejkalova, D. and HuertaandAngeles, G. and Souček, Karel and Hermannova, M. and Vagnerova, H. and Vicha, R. and Velebny, V.},
article_location = {Oxford},
article_number = {OCT},
doi = {http://dx.doi.org/10.1016/j.carbpol.2018.06.082},
keywords = {Hyaluronan; Polymeric micelles; NIR fluorescence imaging; Tumor detection},
language = {eng},
issn = {0144-8617},
journal = {Carbohydrate Polymers},
title = {In vivo monitoring of tumor distribution of hyaluronan polymeric micelles labeled or loaded with near-infrared fluorescence dye},
url = {https://www.sciencedirect.com/science/article/pii/S0144861718307367},
volume = {198},
year = {2018}
}
TY - JOUR
ID - 1590296
AU - Achbergerova, E. - Smejkalova, D. - Huerta-Angeles, G. - Souček, Karel - Hermannova, M. - Vagnerova, H. - Vicha, R. - Velebny, V.
PY - 2018
TI - In vivo monitoring of tumor distribution of hyaluronan polymeric micelles labeled or loaded with near-infrared fluorescence dye
JF - Carbohydrate Polymers
VL - 198
IS - OCT
SP - 339-347
EP - 339-347
PB - ELSEVIER SCI LTD
SN - 01448617
KW - Hyaluronan
KW - Polymeric micelles
KW - NIR fluorescence imaging
KW - Tumor detection
UR - https://www.sciencedirect.com/science/article/pii/S0144861718307367
L2 - https://www.sciencedirect.com/science/article/pii/S0144861718307367
N2 - Development of delivery systems which allow real-time visual inspection of tumors is critical for effective therapy. Near-infrared (NIR) fluorophores have a great potential for such an application. To overcome NIR dyes short blood circulation time and increase tumor accumulation, a NIR dye, cypate, was associated with oleyl hyaluronan, which can self-assemble into polymeric aggregates. The cypate association with oleyl hyaluronan was performed either by a covalent linkage, or physical entrapment. The two systems were compared for tumor targeting and contrast enhancement using BALB/c mice bearing 4T1 breast cancer tumors. Independently on the way of cypate association, it took more than 24 h from intravenous administration to detect NIR signal in tumors and the tumors were clearly visualized for 2 following weeks without substrate reinjection. Covalently linked cypate generated 2-3 fold stronger fluorescence signal than physically loaded cypate. This study demonstrates the potential of HA matrix to be used as carrier of contrast agents for non-invasive long-term tumor visualization.
ER -
ACHBERGEROVA, E., D. SMEJKALOVA, G. HUERTA-ANGELES, Karel SOUČEK, M. HERMANNOVA, H. VAGNEROVA, R. VICHA and V. VELEBNY. In vivo monitoring of tumor distribution of hyaluronan polymeric micelles labeled or loaded with near-infrared fluorescence dye. \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2018, vol.~198, OCT, p.~339-347. ISSN~0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2018.06.082.
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