Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years

VUIK, Fanny E. R., Stella A. V. NIEUWENBURG, Marc BARDOU, Iris LANSDORP-VOGELAAR, Mario DINIS-RIBEIRO, Maria J BENTO, Vesna ZADNIK, Maria PELLISE, Laura ESTEBAN, Michal F. KAMINSKI, Stepan SUCHANEK, Ondřej NGO, Ondřej MÁJEK, Marcis LEJA, Ernst J. KUIPERS and Manon C. W. SPAANDER. Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years. Gut. LONDON: BMJ PUBLISHING GROUP, 2019, vol. 68, No 10, p. 1820-1826. ISSN 0017-5749. Available from: https://dx.doi.org/10.1136/gutjnl-2018-317592.

Basic information

Original name

Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years

Authors

VUIK, Fanny E. R. (528 Netherlands), Stella A. V. NIEUWENBURG (528 Netherlands), Marc BARDOU (528 Netherlands), Iris LANSDORP-VOGELAAR (528 Netherlands), Mario DINIS-RIBEIRO (620 Portugal), Maria J BENTO (620 Portugal), Vesna ZADNIK (705 Slovenia), Maria PELLISE (724 Spain), Laura ESTEBAN (724 Spain), Michal F. KAMINSKI (616 Poland), Stepan SUCHANEK (203 Czech Republic), Ondřej NGO (203 Czech Republic, belonging to the institution), Ondřej MÁJEK (203 Czech Republic, belonging to the institution), Marcis LEJA (203 Czech Republic), Ernst J. KUIPERS (528 Netherlands) and Manon C. W. SPAANDER (528 Netherlands, guarantor)

Edition

Gut, LONDON, BMJ PUBLISHING GROUP, 2019, 0017-5749

---

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30219 Gastroenterology and hepatology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 19.819

RIV identification code

RIV/00216224:14110/19:00111742

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1136/gutjnl-2018-317592

UT WoS

000496491100012

Keywords in English

RISK-FACTORS; COLON-CANCER; METAANALYSIS

Tags

14119612, rivok

Tags

International impact, Reviewed

---

Abstract

V originále

Objective The incidence of colorectal cancer (CRC) declines among subjects aged 50 years and above. An opposite trend appears among younger adults. In Europe, data on CRC incidence among younger adults are lacking. We therefore aimed to analyse European trends in CRC incidence and mortality in subjects younger than 50 years. Design Data on age-related CRC incidence and mortality between 1990 and 2016 were retrieved from national and regional cancer registries. Trends were analysed by Joinpoint regression and expressed as annual percent change. Results We retrieved data on 143.7 million people aged 20-49 years from 20 European countries. Of them, 187 918 (0.13%) were diagnosed with CRC. On average, CRC incidence increased with 7.9% per year among subjects aged 20-29 years from 2004 to 2016. The increase in the age group of 30-39 years was 4.9% per year from 2005 to 2016, the increase in the age group of 40-49 years was 1.6% per year from 2004 to 2016. This increase started earliest in subjects aged 20-29 years, and 10-20 years later in those aged 30-39 and 40-49 years. This is consistent with an age-cohort phenomenon. Although in most European countries the CRC incidence had risen, some heterogeneity was found between countries. CRC mortality did not significantly change among the youngest adults, but decreased with 1.1%per year between 1990 and 2016 and 2.4% per year between 1990 and 2009 among those aged 30-39 years and 40-49 years, respectively. Conclusion CRC incidence rises among young adults in Europe. The cause for this trend needs to be elucidated. Clinicians should be aware of this trend. If the trend continues, screening guidelines may need to be reconsidered.