Plasma levels and leucocyte RNA expression of adipokines in
young patients with coronary artery disease, in metabolic
syndrome and healthy controls

J 2019

Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls

SMEKAL, Ales, Jan VACLAVIK, David STEJSKAL, Klára BENEŠOVÁ, Jiří JARKOVSKÝ et. al.

Základní údaje

Originální název

Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls

Autoři

SMEKAL, Ales (203 Česká republika), Jan VACLAVIK (203 Česká republika, garant), David STEJSKAL (203 Česká republika), Klára BENEŠOVÁ (203 Česká republika, domácí), Jiří JARKOVSKÝ (203 Česká republika, domácí), Gabriela SVOBODOVA (203 Česká republika), Radmila RICHTEROVA (203 Česká republika), Marek SVESTAK (203 Česká republika) a Milos TABORSKY (203 Česká republika)

Vydání

Cytokine, LONDON, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2019, 1043-4666

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.952

Kód RIV

RIV/00216224:14110/19:00111746

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.cyto.2017.03.016

UT WoS

000488662600003

Klíčová slova anglicky

Adipokines; Adipokine expression; Acute myocardial infarction; Metabolic syndrome; Premature coronary artery disease; Young adults

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 6. 2020 08:52, Mgr. Tereza Miškechová

Anotace

V originále

Objectives: Little is known about the role of adipokines in the pathogenesis of coronary artery disease in young patients. The aims of this study were to compare serum levels of adipokines and expression of adipokines in peripheral blood leukocytes in patients with premature coronary artery disease (CAD), metabolic syndrome and healthy individuals. Design and methods: Sixty-five patients with premature CAD (men 18-45 years old and women 18-55 years old) formed the study group. The control groups were 75 patients with metabolic syndrome and 50 healthy individuals. For each group, RNA expression in peripheral blood leukocytes was determined for 24 different adipokines and 11 adipokines were examined in serum. Results: In individuals with CAD, serum visfatin levels were significantly higher than in metabolic syndrome and healthy controls (2.3 vs. 1.6 vs. 0.7 mu g/L, P < 0.001) while both omentin-1 (92.9 vs. 587.0 vs. 552.3 mu g/L, P < 0.001) and ZAG2 (45.5 vs. 72.5 vs. 77.1 mg/L, P < 0.001) levels were lower. The receiver operating curve (ROC) analysis for testing the validity of these adipokines in the diagnosis of CAD compared to control groups provided the following areas under the curve (AUC): omentin-1 AUC 0.97 (cut-off <= 222 mu g/L), ZAG2 AUC 0.89 (cut-off <= 51.7 mg/L) and visfatin AUC 0.74 (cut-off >= 1.0 mu g/L) (P < 0.001 in all cases). Visfatin and omentin-1 serum levels did not differ between the acute phase of myocardial infarction and the chronic phase of CAD. In patients with CAD, we found no significant relation between mRNA expression and adipokine concentration. Conclusion: Serum omentin-1, visfatin and ZAG2 could serve as biomarkers of premature CAD in young apparently healthy people.

Citovat

SMEKAL, Ales, Jan VACLAVIK, David STEJSKAL, Klára BENEŠOVÁ, Jiří JARKOVSKÝ, Gabriela SVOBODOVA, Radmila RICHTEROVA, Marek SVESTAK a Milos TABORSKY. Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls. Cytokine. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2019, roč. 122, OCT 2019, s. 1-7. ISSN 1043-4666. Dostupné z: https://dx.doi.org/10.1016/j.cyto.2017.03.016.

@article{1593121,
   author = {Smekal, Ales and Vaclavik, Jan and Stejskal, David and Benešová, Klára and Jarkovský, Jiří and Svobodova, Gabriela and Richterova, Radmila and Svestak, Marek and Taborsky, Milos},
   article_location = {LONDON},
   article_number = {OCT 2019},
   doi = {http://dx.doi.org/10.1016/j.cyto.2017.03.016},
   keywords = {Adipokines; Adipokine expression; Acute myocardial infarction; Metabolic syndrome; Premature coronary artery disease; Young adults},
   language = {eng},
   issn = {1043-4666},
   journal = {Cytokine},
   title = {Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls},
   url = {http://dx.doi.org/10.1016/j.cyto.2017.03.016},
   volume = {122},
   year = {2019}
}

TY  - JOUR
ID  - 1593121
AU  - Smekal, Ales - Vaclavik, Jan - Stejskal, David - Benešová, Klára - Jarkovský, Jiří - Svobodova, Gabriela - Richterova, Radmila - Svestak, Marek - Taborsky, Milos
PY  - 2019
TI  - Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls
JF  - Cytokine
VL  - 122
IS  - OCT 2019
SP  - 1-7
EP  - 1-7
PB  - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
SN  - 10434666
KW  - Adipokines
KW  - Adipokine expression
KW  - Acute myocardial infarction
KW  - Metabolic syndrome
KW  - Premature coronary artery disease
KW  - Young adults
UR  - http://dx.doi.org/10.1016/j.cyto.2017.03.016
L2  - http://dx.doi.org/10.1016/j.cyto.2017.03.016
N2  - Objectives: Little is known about the role of adipokines in the pathogenesis of coronary artery disease in young patients. The aims of this study were to compare serum levels of adipokines and expression of adipokines in peripheral blood leukocytes in patients with premature coronary artery disease (CAD), metabolic syndrome and healthy individuals. Design and methods: Sixty-five patients with premature CAD (men 18-45 years old and women 18-55 years old) formed the study group. The control groups were 75 patients with metabolic syndrome and 50 healthy individuals. For each group, RNA expression in peripheral blood leukocytes was determined for 24 different adipokines and 11 adipokines were examined in serum. Results: In individuals with CAD, serum visfatin levels were significantly higher than in metabolic syndrome and healthy controls (2.3 vs. 1.6 vs. 0.7 mu g/L, P < 0.001) while both omentin-1 (92.9 vs. 587.0 vs. 552.3 mu g/L, P < 0.001) and ZAG2 (45.5 vs. 72.5 vs. 77.1 mg/L, P < 0.001) levels were lower. The receiver operating curve (ROC) analysis for testing the validity of these adipokines in the diagnosis of CAD compared to control groups provided the following areas under the curve (AUC): omentin-1 AUC 0.97 (cut-off <= 222 mu g/L), ZAG2 AUC 0.89 (cut-off <= 51.7 mg/L) and visfatin AUC 0.74 (cut-off >= 1.0 mu g/L) (P < 0.001 in all cases). Visfatin and omentin-1 serum levels did not differ between the acute phase of myocardial infarction and the chronic phase of CAD. In patients with CAD, we found no significant relation between mRNA expression and adipokine concentration. Conclusion: Serum omentin-1, visfatin and ZAG2 could serve as biomarkers of premature CAD in young apparently healthy people.
ER  -

SMEKAL, Ales, Jan VACLAVIK, David STEJSKAL, Klára BENEŠOVÁ, Jiří JARKOVSKÝ, Gabriela SVOBODOVA, Radmila RICHTEROVA, Marek SVESTAK a Milos TABORSKY. Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls. \textit{Cytokine}. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2019, roč.~122, OCT 2019, s.~1-7. ISSN~1043-4666. Dostupné z: https://dx.doi.org/10.1016/j.cyto.2017.03.016.

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