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@article{1593121,
author = {Smekal, Ales and Vaclavik, Jan and Stejskal, David and Benešová, Klára and Jarkovský, Jiří and Svobodova, Gabriela and Richterova, Radmila and Svestak, Marek and Taborsky, Milos},
article_location = {LONDON},
article_number = {OCT 2019},
doi = {http://dx.doi.org/10.1016/j.cyto.2017.03.016},
keywords = {Adipokines; Adipokine expression; Acute myocardial infarction; Metabolic syndrome; Premature coronary artery disease; Young adults},
language = {eng},
issn = {1043-4666},
journal = {Cytokine},
title = {Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls},
url = {http://dx.doi.org/10.1016/j.cyto.2017.03.016},
volume = {122},
year = {2019}
}
TY - JOUR
ID - 1593121
AU - Smekal, Ales - Vaclavik, Jan - Stejskal, David - Benešová, Klára - Jarkovský, Jiří - Svobodova, Gabriela - Richterova, Radmila - Svestak, Marek - Taborsky, Milos
PY - 2019
TI - Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls
JF - Cytokine
VL - 122
IS - OCT 2019
SP - 1-7
EP - 1-7
PB - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
SN - 10434666
KW - Adipokines
KW - Adipokine expression
KW - Acute myocardial infarction
KW - Metabolic syndrome
KW - Premature coronary artery disease
KW - Young adults
UR - http://dx.doi.org/10.1016/j.cyto.2017.03.016
L2 - http://dx.doi.org/10.1016/j.cyto.2017.03.016
N2 - Objectives: Little is known about the role of adipokines in the pathogenesis of coronary artery disease in young patients. The aims of this study were to compare serum levels of adipokines and expression of adipokines in peripheral blood leukocytes in patients with premature coronary artery disease (CAD), metabolic syndrome and healthy individuals. Design and methods: Sixty-five patients with premature CAD (men 18-45 years old and women 18-55 years old) formed the study group. The control groups were 75 patients with metabolic syndrome and 50 healthy individuals. For each group, RNA expression in peripheral blood leukocytes was determined for 24 different adipokines and 11 adipokines were examined in serum. Results: In individuals with CAD, serum visfatin levels were significantly higher than in metabolic syndrome and healthy controls (2.3 vs. 1.6 vs. 0.7 mu g/L, P < 0.001) while both omentin-1 (92.9 vs. 587.0 vs. 552.3 mu g/L, P < 0.001) and ZAG2 (45.5 vs. 72.5 vs. 77.1 mg/L, P < 0.001) levels were lower. The receiver operating curve (ROC) analysis for testing the validity of these adipokines in the diagnosis of CAD compared to control groups provided the following areas under the curve (AUC): omentin-1 AUC 0.97 (cut-off <= 222 mu g/L), ZAG2 AUC 0.89 (cut-off <= 51.7 mg/L) and visfatin AUC 0.74 (cut-off >= 1.0 mu g/L) (P < 0.001 in all cases). Visfatin and omentin-1 serum levels did not differ between the acute phase of myocardial infarction and the chronic phase of CAD. In patients with CAD, we found no significant relation between mRNA expression and adipokine concentration. Conclusion: Serum omentin-1, visfatin and ZAG2 could serve as biomarkers of premature CAD in young apparently healthy people.
ER -
SMEKAL, Ales, Jan VACLAVIK, David STEJSKAL, Klára BENEŠOVÁ, Jiří JARKOVSKÝ, Gabriela SVOBODOVA, Radmila RICHTEROVA, Marek SVESTAK a Milos TABORSKY. Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls. \textit{Cytokine}. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2019, roč.~122, OCT 2019, s.~1-7. ISSN~1043-4666. Dostupné z: https://dx.doi.org/10.1016/j.cyto.2017.03.016.
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