Heterochromatinization associated with cell differentiation as
a model to study DNA double strandbreak induction and repair in
the context of higher-order chromatin structure

J 2014

Heterochromatinization associated with cell differentiation as a model to study DNA double strandbreak induction and repair in the context of higher-order chromatin structure

FALK, Martin, Emilie LUKÁŠOVÁ, Lenka ŠTEFANČÍKOVÁ, E BARANOVÁ, I FALKOVÁ et. al.

Basic information

Original name

Heterochromatinization associated with cell differentiation as a model to study DNA double strandbreak induction and repair in the context of higher-order chromatin structure

Authors

FALK, Martin, Emilie LUKÁŠOVÁ, Lenka ŠTEFANČÍKOVÁ, E BARANOVÁ, I FALKOVÁ, L JEŽKOVÁ, M Bačíková A DAVÍDKOVÁ, J VACHELOVÁ, A MICHAELIDESOVÁ and Stanislav KOZUBEK

Edition

Applied Radiation and Isotopes, Elsevier, 2014, 0969-8043

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.231

DOI

http://dx.doi.org/10.1016/j.apradiso.2013.01.029

Abstract

V originále

Cell differentiation is associated with extensive gene silencing, heterochromatinization and potentially decreasing need for repairing DNA double-strand breaks (DSBs). Differentiation stages of blood cells thus represent an excellent model to study DSB induction, repair and misrepair in the context of changing higher-order chromatin structure. We show that immature granulocytes form γH2AX and 53BP1 foci, contrary to the mature cells; however, these foci colocalize only rarely and DSB repair is inefficient. Moreover, specific chromatin structure of granulocytes probably influences DSB induction.

Citovat

FALK, Martin, Emilie LUKÁŠOVÁ, Lenka ŠTEFANČÍKOVÁ, E BARANOVÁ, I FALKOVÁ, L JEŽKOVÁ, M Bačíková A DAVÍDKOVÁ, J VACHELOVÁ, A MICHAELIDESOVÁ and Stanislav KOZUBEK. Heterochromatinization associated with cell differentiation as a model to study DNA double strandbreak induction and repair in the context of higher-order chromatin structure. Applied Radiation and Isotopes. Elsevier, 2014, vol. 83, p. 177-185. ISSN 0969-8043. Available from: https://dx.doi.org/10.1016/j.apradiso.2013.01.029.

@article{1594217,
   author = {Falk, Martin and Lukášová, Emilie and Štefančíková, Lenka and Baranová, E and Falková, I and Ježková, L and Davídková, M Bačíková A and Vachelová, J and Michaelidesová, A and Kozubek, Stanislav},
   doi = {http://dx.doi.org/10.1016/j.apradiso.2013.01.029},
   language = {eng},
   issn = {0969-8043},
   journal = {Applied Radiation and Isotopes},
   title = {Heterochromatinization associated with cell differentiation as a model to study DNA double strandbreak induction and repair in the context of higher-order chromatin structure},
   volume = {83},
   year = {2014}
}

TY  - JOUR
ID  - 1594217
AU  - Falk, Martin - Lukášová, Emilie - Štefančíková, Lenka - Baranová, E - Falková, I - Ježková, L - Davídková, M Bačíková A - Vachelová, J - Michaelidesová, A - Kozubek, Stanislav
PY  - 2014
TI  - Heterochromatinization associated with cell differentiation as a model to study DNA double strandbreak induction and repair in the context of higher-order chromatin structure
JF  - Applied Radiation and Isotopes
VL  - 83
SP  - 177-185
EP  - 177-185
PB  - Elsevier
SN  - 09698043
N2  - Cell differentiation is associated with extensive gene silencing, heterochromatinization and potentially decreasing need for repairing DNA double-strand breaks (DSBs). Differentiation stages of blood cells thus represent an excellent model to study DSB induction, repair and misrepair in the context of changing higher-order chromatin structure. We show that immature granulocytes form γH2AX and 53BP1 foci, contrary to the mature cells; however, these foci colocalize only rarely and DSB repair is inefficient. Moreover, specific chromatin structure of granulocytes probably influences DSB induction.
ER  -

FALK, Martin, Emilie LUKÁŠOVÁ, Lenka ŠTEFANČÍKOVÁ, E BARANOVÁ, I FALKOVÁ, L JEŽKOVÁ, M Bačíková A DAVÍDKOVÁ, J VACHELOVÁ, A MICHAELIDESOVÁ and Stanislav KOZUBEK. Heterochromatinization associated with cell differentiation as a model to study DNA double strandbreak induction and repair in the context of higher-order chromatin structure. \textit{Applied Radiation and Isotopes}. Elsevier, 2014, vol.~83, p.~177-185. ISSN~0969-8043. Available from: https://dx.doi.org/10.1016/j.apradiso.2013.01.029.

Detailed Information on Publication Record