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@article{1600359, author = {Radujkovic, Aleksandar and Dietrich, Sascha and Blok, HenricandJan and Nagler, Arnon and Ayuk, Francis and Finke, Juergen and Tischer, Johanna and Mayer, Jiří and Koc, Yener and Sora, Federica and Passweg, Jakob and Byrne, Jenny L. and Jindra, Pavel and Veelken, Joan Hendrik and Socie, Gerard and Maertens, Johan and Schaap, Nicolaas and Stadler, Michael and ItalaandRemes, Maija and Tholouli, Eleni and Arat, Mutlu and Rocha, Vanderson and Ljungman, Per and YakoubandAgha, Ibrahim and Kroger, Nicolaus and Chalandon, Yves}, article_location = {New York}, article_number = {10}, doi = {http://dx.doi.org/10.1016/j.bbmt.2019.06.028}, keywords = {Chronic myeloid leukemia; Allogeneic stem cell; transplantation; Outcome; Blast crisis; Tyrosine kinase inhibitor}, language = {eng}, issn = {1083-8791}, journal = {Biology of Blood and Marrow Transplantation}, title = {Allogeneic Stem Cell Transplantation for Blast Crisis Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: A Retrospective Study by the EBMT Chronic Malignancies Working Party}, url = {http://dx.doi.org/10.1016/j.bbmt.2019.06.028}, volume = {25}, year = {2019} }
TY - JOUR ID - 1600359 AU - Radujkovic, Aleksandar - Dietrich, Sascha - Blok, Henric-Jan - Nagler, Arnon - Ayuk, Francis - Finke, Juergen - Tischer, Johanna - Mayer, Jiří - Koc, Yener - Sora, Federica - Passweg, Jakob - Byrne, Jenny L. - Jindra, Pavel - Veelken, Joan Hendrik - Socie, Gerard - Maertens, Johan - Schaap, Nicolaas - Stadler, Michael - Itala-Remes, Maija - Tholouli, Eleni - Arat, Mutlu - Rocha, Vanderson - Ljungman, Per - Yakoub-Agha, Ibrahim - Kroger, Nicolaus - Chalandon, Yves PY - 2019 TI - Allogeneic Stem Cell Transplantation for Blast Crisis Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: A Retrospective Study by the EBMT Chronic Malignancies Working Party JF - Biology of Blood and Marrow Transplantation VL - 25 IS - 10 SP - 2008-2016 EP - 2008-2016 PB - Elsevier Science INC SN - 10838791 KW - Chronic myeloid leukemia KW - Allogeneic stem cell KW - transplantation KW - Outcome KW - Blast crisis KW - Tyrosine kinase inhibitor UR - http://dx.doi.org/10.1016/j.bbmt.2019.06.028 L2 - http://dx.doi.org/10.1016/j.bbmt.2019.06.028 N2 - The prognosis of patients with blast crisis (BC) chronic myeloid leukemia (CML) is still dismal. Allogeneic stem cell transplantation represents the only curative treatment option, but data on transplant outcomes are scarce. We therefore conducted a retrospective, registry-based study of adult patients allografted for BC CML, focusing on patients with active disease at transplant and pretransplant prognostic factors. One hundred seventy patients allografted for BC CML after tyrosine kinase inhibitor pretreatment between 2004 and 2016 were analyzed. Before transplant, 95 patients were in remission, whereas 75 patients had active BC. In multivariable analysis of the entire cohort, active BC at transplant was the strongest factor associated with decreased overall survival (hazrd ratio, 1.87; P = .010) and shorter leukemia-free survival (LFS; hazard ratio, 1.69; P= .017). For patients with BC in remission at transplant, advanced age (>= 45 years), lower performance status (<= 80%), longer interval from diagnosis BC to transplant (>12 months), myeloablative conditioning, and unrelated donor (UD) transplant were risk factors for inferior survival. In patients with active BC, only UD transplant was significantly associated with prolonged LFS and trended toward improved overall survival. In summary, survival of patients allografted for BC CML was strongly dependent on pretransplant remission status. In patients with remission of BC, conventional prognostic factors remained the major determinants of outcome, whereas in those with active BC at transplant, UD transplant was associated with prolonged LFS in our study. (C) 2019 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. ER -
RADUJKOVIC, Aleksandar, Sascha DIETRICH, Henric-Jan BLOK, Arnon NAGLER, Francis AYUK, Juergen FINKE, Johanna TISCHER, Jiří MAYER, Yener KOC, Federica SORA, Jakob PASSWEG, Jenny L. BYRNE, Pavel JINDRA, Joan Hendrik VEELKEN, Gerard SOCIE, Johan MAERTENS, Nicolaas SCHAAP, Michael STADLER, Maija ITALA-REMES, Eleni THOLOULI, Mutlu ARAT, Vanderson ROCHA, Per LJUNGMAN, Ibrahim YAKOUB-AGHA, Nicolaus KROGER a Yves CHALANDON. Allogeneic Stem Cell Transplantation for Blast Crisis Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: A Retrospective Study by the EBMT Chronic Malignancies Working Party. \textit{Biology of Blood and Marrow Transplantation}. New York: Elsevier Science INC, 2019, roč.~25, č.~10, s.~2008-2016. ISSN~1083-8791. Dostupné z: https://dx.doi.org/10.1016/j.bbmt.2019.06.028.
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