Lectins from human pathogenic bacterium Photorhabdus
asymbiotica

a 2019

Lectins from human pathogenic bacterium Photorhabdus asymbiotica

MELICHER, Filip, Josef HOUSER, Gita JANČAŘÍKOVÁ, Daniel POKORNÝ, Michaela WIMMEROVÁ et. al.

Základní údaje

Originální název

Lectins from human pathogenic bacterium Photorhabdus asymbiotica

Autoři

MELICHER, Filip (703 Slovensko, domácí), Josef HOUSER (203 Česká republika, domácí), Gita JANČAŘÍKOVÁ (203 Česká republika, domácí), Daniel POKORNÝ (203 Česká republika, domácí) a Michaela WIMMEROVÁ (203 Česká republika, garant, domácí)

Vydání

XX. setkání biochemiků a molekulárních biologů, 2019

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

10600 1.6 Biological sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/19:00107975

Organizační jednotka

Přírodovědecká fakulta

ISBN

978-80-210-9420-8

Klíčová slova česky

lektíny; photorhabuds asymbiotica; lidský patogén

Klíčová slova anglicky

Lectins; photorhabuds asymbiotica; human pathogen

Změněno: 23. 1. 2020 01:28, prof. RNDr. Michaela Wimmerová, Ph.D.

Anotace

V originále

Lectins are ubiquitous proteins and glycoproteins with the ability to specifically, non-covalently and reversibly bind to the mono-, oligo- and polysaccharides. These sugar-binding proteins can be found in most organisms, ranging from viruses and bacteria to plants and animals. They play an important role in many processes occurring in nature such as cell-cell interaction or recognition of the host by a pathogen. Lectins represent a heterogeneous group of proteins that vary in size, oligomeric state, structure as well as in exhibit specificity. Due to their importance, lectins are studied structurally and functionally to completely understand their role and mechanism of action. Our research focuses on the lectins from gram-negative entomopathogenic bacteria Photorhabdus asymbiotica, which live in symbiosis with Heterorhabditis nematodes. This symbiotic complex can be found in soil, where it searches for the insect prey. Even though the Photorhabdus genus is mainly insect pathogen there are also clinical cases describing a human infection caused by this bacterium. P. asymbiotica produces the well-characterized lectin PHL which has a seven-bladed beta-propeller fold and contains two types of binding sites for different ligands. In addition, bioinformatic analysis of the P. asymbiotica genome revealed a presence of two additional genes for homologous proteins with the PHL lectin. Several sugar-binding proteins with unknown function and dual behaviour makes P. asymbiotica a compelling organism and further studies of biomolecules produced by this bacterium may reveal their importance in the pathogenic or a symbiotic stage of life.

Návaznosti

GA18-18964S, projekt VaV

Název: Lektiny a jejich úloha v interakci patogen/hostitel a buněčném rozpoznávání

Investor: Grantová agentura ČR, Lektiny a jejich úloha v interakci patogen/hostitel a buněčném rozpoznávání

Citovat

MELICHER, Filip, Josef HOUSER, Gita JANČAŘÍKOVÁ, Daniel POKORNÝ a Michaela WIMMEROVÁ. Lectins from human pathogenic bacterium Photorhabdus asymbiotica. In XX. setkání biochemiků a molekulárních biologů. 2019. ISBN 978-80-210-9420-8.

@proceedings{1601176,
   author = {Melicher, Filip and Houser, Josef and Jančaříková, Gita and Pokorný, Daniel and Wimmerová, Michaela},
   booktitle = {XX. setkání biochemiků a molekulárních biologů},
   keywords = {Lectins; photorhabuds asymbiotica; human pathogen},
   language = {eng},
   isbn = {978-80-210-9420-8},
   title = {Lectins from human pathogenic bacterium Photorhabdus asymbiotica},
   year = {2019}
}

TY  - CONF
ID  - 1601176
AU  - Melicher, Filip - Houser, Josef - Jančaříková, Gita - Pokorný, Daniel - Wimmerová, Michaela
PY  - 2019
TI  - Lectins from human pathogenic bacterium Photorhabdus asymbiotica
SN  - 9788021094208
KW  - Lectins
KW  - photorhabuds asymbiotica
KW  - human pathogen
N2  - Lectins are ubiquitous proteins and glycoproteins with the ability to specifically, non-covalently and reversibly bind to the mono-, oligo- and polysaccharides. These sugar-binding proteins can be found in most organisms, ranging from viruses and bacteria to plants and animals. They play an important role in many processes occurring in nature such as cell-cell interaction or recognition of the host by a pathogen. Lectins represent a heterogeneous group of proteins that vary in size, oligomeric state, structure as well as in exhibit specificity. Due to their importance, lectins are studied structurally and functionally to completely understand their role and mechanism of action. Our research focuses on the lectins from gram-negative entomopathogenic bacteria Photorhabdus asymbiotica, which live in symbiosis with Heterorhabditis nematodes. This symbiotic complex can be found in soil, where it searches for the insect prey. Even though the Photorhabdus genus is mainly insect pathogen there are also clinical cases describing a human infection caused by this bacterium. P. asymbiotica produces the well-characterized lectin PHL which has a seven-bladed beta-propeller fold and contains two types of binding sites for different ligands. In addition, bioinformatic analysis of the P. asymbiotica genome revealed a presence of two additional genes for homologous proteins with the PHL lectin. Several sugar-binding proteins with unknown function and dual behaviour makes P. asymbiotica a compelling organism and further studies of biomolecules produced by this bacterium may reveal their importance in the pathogenic or a symbiotic stage of life.
ER  -

MELICHER, Filip, Josef HOUSER, Gita JANČAŘÍKOVÁ, Daniel POKORNÝ a Michaela WIMMEROVÁ. Lectins from human pathogenic bacterium Photorhabdus asymbiotica. In \textit{XX. setkání biochemiků a molekulárních biologů}. 2019. ISBN~978-80-210-9420-8.

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