Pathologies of Oral Patterning - Odontogenic Tumors and Cysts

a 2019

Pathologies of Oral Patterning - Odontogenic Tumors and Cysts

ŠTEMBÍREK, Jan, M. HOVORAKOVA, I. PUTNOVA, B. PUTNOVA, Eva HRUBÁ et. al.

Basic information

Original name

Pathologies of Oral Patterning - Odontogenic Tumors and Cysts

Authors

ŠTEMBÍREK, Jan (203 Czech Republic), M. HOVORAKOVA (203 Czech Republic), I. PUTNOVA (203 Czech Republic), B. PUTNOVA (203 Czech Republic), Eva HRUBÁ (203 Czech Republic), Pavel HURNÍK (203 Czech Republic), Vítězslav BRYJA (203 Czech Republic, belonging to the institution), Zdeněk DANĚK (203 Czech Republic, belonging to the institution), M. BARTOS (203 Czech Republic) and O. ZAHRADNICEK (203 Czech Republic)

Edition

12th International Congress of Vertebrate Morphology, 2019

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30106 Anatomy and morphology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.563

RIV identification code

RIV/00216224:14110/19:00112375

Organization unit

Faculty of Medicine

ISSN

UT WoS

000470768500081

Keywords in English

Oral Patterning; Odontogenic Tumors; Cysts

Abstract

V originále

The oral cavity is an area of numerous pathologies present not only within, but also outside the dental arch. The presence of supernumerary ectopically located teeth in non-dental areas or pathologies with dental tissue formation in non-dental areas evokes the questions how these pathologies are formed and what their origin is. One of the tissues maintaining an odontogenic potential is the prospective oral vestibule located externally to the developing dentition. In case the signaling is awoken, it might explain the presence of pathologies externally to the dentition with signs of possible tooth-associated structure formation. Also during successional dental lamina disintegration, some lamina cells remain in small islands known as the rests of Serres or as epithelial pearls. These epithelial remnants are of general interest for human clinicians because they can give rise to cysts or odontogenic tumors. Odontogenic cysts are enclosed epithelial sacs with a distinct membrane derived from the rests of the odontogenic epithelium. Odontogenic tumors are pathological lesions derived from the epithelial and/or mesenchymal remnants of tooth germs. In addition, dental hard tissue may or may not be included in these lesions. The precise mechanisms controlling the initiation of odontogenic cysts or tumors are however still unknown. Uncovering the signaling pathologies and altered cell communication between epithelial and mesenchymal components could explain the mechanisms driving the initiation of tumors or cysts in our patients. As this field is largely unexplored, an association of clinical findings with molecular events in individual patients could help us to predict the patient's prognosis and to plan directly targeted treatment.

Citovat

ŠTEMBÍREK, Jan, M. HOVORAKOVA, I. PUTNOVA, B. PUTNOVA, Eva HRUBÁ, Pavel HURNÍK, Vítězslav BRYJA, Zdeněk DANĚK, M. BARTOS and O. ZAHRADNICEK. Pathologies of Oral Patterning - Odontogenic Tumors and Cysts. In 12th International Congress of Vertebrate Morphology. 2019. ISSN 0362-2525.

@proceedings{1603977,
   author = {Štembírek, Jan and Hovorakova, M. and Putnova, I. and Putnova, B. and Hrubá, Eva and Hurník, Pavel and Bryja, Vítězslav and Daněk, Zdeněk and Bartos, M. and Zahradnicek, O.},
   booktitle = {12th International Congress of Vertebrate Morphology},
   keywords = {Oral Patterning; Odontogenic Tumors; Cysts},
   language = {eng},
   title = {Pathologies of Oral Patterning - Odontogenic Tumors and Cysts},
   year = {2019}
}

TY  - CONF
ID  - 1603977
AU  - Štembírek, Jan - Hovorakova, M. - Putnova, I. - Putnova, B. - Hrubá, Eva - Hurník, Pavel - Bryja, Vítězslav - Daněk, Zdeněk - Bartos, M. - Zahradnicek, O.
PY  - 2019
TI  - Pathologies of Oral Patterning - Odontogenic Tumors and Cysts
KW  - Oral Patterning
KW  - Odontogenic Tumors
KW  - Cysts
N2  - The oral cavity is an area of numerous pathologies present not only within, but also outside the dental arch. The presence of supernumerary ectopically located teeth in non-dental areas or pathologies with dental tissue formation in non-dental areas evokes the questions how these pathologies are formed and what their origin is. One of the tissues maintaining an odontogenic potential is the prospective oral vestibule located externally to the developing dentition. In case the signaling is awoken, it might explain the presence of pathologies externally to the dentition with signs of possible tooth-associated structure formation. Also during successional dental lamina disintegration, some lamina cells remain in small islands known as the rests of Serres or as epithelial pearls. These epithelial remnants are of general interest for human clinicians because they can give rise to cysts or odontogenic tumors. Odontogenic cysts are enclosed epithelial sacs with a distinct membrane derived from the rests of the odontogenic epithelium. Odontogenic tumors are pathological lesions derived from the epithelial and/or mesenchymal remnants of tooth germs. In addition, dental hard tissue may or may not be included in these lesions. The precise mechanisms controlling the initiation of odontogenic cysts or tumors are however still unknown. Uncovering the signaling pathologies and altered cell communication between epithelial and mesenchymal components could explain the mechanisms driving the initiation of tumors or cysts in our patients. As this field is largely unexplored, an association of clinical findings with molecular events in individual patients could help us to predict the patient's prognosis and to plan directly targeted treatment.
ER  -

ŠTEMBÍREK, Jan, M. HOVORAKOVA, I. PUTNOVA, B. PUTNOVA, Eva HRUBÁ, Pavel HURNÍK, Vítězslav BRYJA, Zdeněk DANĚK, M. BARTOS and O. ZAHRADNICEK. Pathologies of Oral Patterning - Odontogenic Tumors and Cysts. In \textit{12th International Congress of Vertebrate Morphology}. 2019. ISSN~0362-2525.

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