Strain diversity of Treponema pallidum subsp. pertenue suggests
rare interspecies transmission in African nonhuman primates

J 2019

Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates

CHUMA, Idrissa S., Christian ROOS, Anagaw ATICKEM, Torsten BOHM, D. Anthony COLLINS et. al.

Základní údaje

Originální název

Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates

Autoři

CHUMA, Idrissa S. (276 Německo), Christian ROOS (276 Německo), Anagaw ATICKEM (231 Etiopie), Torsten BOHM (178 Konžská republika), D. Anthony COLLINS (834 Tanzanie), Linda GRILLOVÁ (203 Česká republika, domácí), Luisa K. HALLMAIER-WACKER (276 Německo), Rudovick R. KAZWALA (834 Tanzanie), Julius D. KEYYU (834 Tanzanie), Simone LUERT (276 Německo), Ulrich MALOUEKI (178 Konžská republika), Jan OPPELT (203 Česká republika, domácí), Klara J. PETRZELKOVA (203 Česká republika), Alexander PIEL (826 Velká Británie a Severní Irsko), Fiona A. STEWART (826 Velká Británie a Severní Irsko), David ŠMAJS (203 Česká republika, domácí) a Sascha KNAUF (276 Německo, garant)

Vydání

Scientific reports, LONDON, NATURE PUBLISHING GROUP, 2019, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.998

Kód RIV

RIV/00216224:14110/19:00108042

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41598-019-50779-9

UT WoS

000488482200025

Klíčová slova anglicky

RIBOSOMAL-RNA GENE; MACROLIDE RESISTANCE; INFECTION; MUTATION; TREE

Štítky

14110513, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 10. 2024 16:36, Ing. Marie Švancarová

Anotace

V originále

In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.

Návaznosti

GA17-25455S, projekt VaV

Název: Studium genomů patogenních treponem na základě analýzy jednotlivých buněk

Investor: Grantová agentura ČR, Studium genomů patogenních treponem na základě analýzy jednotlivých buněk

GC18-23521J, projekt VaV

Název: Treponematózy u zástupců řádu zajícovci: genetická diverzita treponem a příbuznost s lidským patogenem T. pallidum

Investor: Grantová agentura ČR, Treponematózy u zástupců řádu zajícovci: genetická diverzita treponem a příbuznost s lidským patogenem T. pallidum

MUNI/A/1087/2018, interní kód MU

Název: Molekulární a buněčná biologie pro biomedicínské vědy

Investor: Masarykova univerzita, Molekulární a buněčná biologie pro biomedicínské vědy, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

90091, velká výzkumná infrastruktura

Název: NCMG

Citovat

CHUMA, Idrissa S., Christian ROOS, Anagaw ATICKEM, Torsten BOHM, D. Anthony COLLINS, Linda GRILLOVÁ, Luisa K. HALLMAIER-WACKER, Rudovick R. KAZWALA, Julius D. KEYYU, Simone LUERT, Ulrich MALOUEKI, Jan OPPELT, Klara J. PETRZELKOVA, Alexander PIEL, Fiona A. STEWART, David ŠMAJS a Sascha KNAUF. Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2019, roč. 9, OCT 2 2019, s. 1-9. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-019-50779-9.

@article{1604496,
   author = {Chuma, Idrissa S. and Roos, Christian and Atickem, Anagaw and Bohm, Torsten and Collins, D. Anthony and Grillová, Linda and HallmaierandWacker, Luisa K. and Kazwala, Rudovick R. and Keyyu, Julius D. and Luert, Simone and Maloueki, Ulrich and Oppelt, Jan and Petrzelkova, Klara J. and Piel, Alexander and Stewart, Fiona A. and Šmajs, David and Knauf, Sascha},
   article_location = {LONDON},
   article_number = {OCT 2 2019},
   doi = {http://dx.doi.org/10.1038/s41598-019-50779-9},
   keywords = {RIBOSOMAL-RNA GENE; MACROLIDE RESISTANCE; INFECTION; MUTATION; TREE},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates},
   url = {https://www.nature.com/articles/s41598-019-50779-9.pdf},
   volume = {9},
   year = {2019}
}

TY  - JOUR
ID  - 1604496
AU  - Chuma, Idrissa S. - Roos, Christian - Atickem, Anagaw - Bohm, Torsten - Collins, D. Anthony - Grillová, Linda - Hallmaier-Wacker, Luisa K. - Kazwala, Rudovick R. - Keyyu, Julius D. - Luert, Simone - Maloueki, Ulrich - Oppelt, Jan - Petrzelkova, Klara J. - Piel, Alexander - Stewart, Fiona A. - Šmajs, David - Knauf, Sascha
PY  - 2019
TI  - Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates
JF  - Scientific reports
VL  - 9
IS  - OCT 2 2019
SP  - 1-9
EP  - 1-9
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - RIBOSOMAL-RNA GENE
KW  - MACROLIDE RESISTANCE
KW  - INFECTION
KW  - MUTATION
KW  - TREE
UR  - https://www.nature.com/articles/s41598-019-50779-9.pdf
L2  - https://www.nature.com/articles/s41598-019-50779-9.pdf
N2  - In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.
ER  -

CHUMA, Idrissa S., Christian ROOS, Anagaw ATICKEM, Torsten BOHM, D. Anthony COLLINS, Linda GRILLOVÁ, Luisa K. HALLMAIER-WACKER, Rudovick R. KAZWALA, Julius D. KEYYU, Simone LUERT, Ulrich MALOUEKI, Jan OPPELT, Klara J. PETRZELKOVA, Alexander PIEL, Fiona A. STEWART, David ŠMAJS a Sascha KNAUF. Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2019, roč.~9, OCT 2 2019, s.~1-9. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-019-50779-9.

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