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@article{1605485,
author = {EstebanandGil, Angel and PerezandSanz, Fernando and GarciaandSolano, Jose and AlburquerqueandGonzalez, Begona and ParrenoandGonzalez, Maria and LegazandGarcia, Maria del Carmen and FernandezandBreis, Jesualdo Tomas and RodriguezandBraun, Edith and Pimentel, Paola and Tuomisto, Anne and Makinen, Markus and Slabý, Ondřej and ConesaandZamora, Pablo},
article_location = {LONDON},
article_number = {OCT 31 2019},
doi = {http://dx.doi.org/10.1038/s41597-019-0198-z},
keywords = {MICROSATELLITE INSTABILITY; PROMOTER HYPERMETHYLATION; SERRATED POLYPS; COLON-CANCER; PHENOTYPE; CARCINOGENESIS; ADENOCARCINOMA; BIOMARKERS; PATHWAYS; GENES},
language = {eng},
issn = {2052-4463},
journal = {SCIENTIFIC DATA},
title = {ColPortal, an integrative multiomic platform for analysing epigenetic interactions in colorectal cancer},
url = {https://www.nature.com/articles/s41597-019-0198-z.pdf},
volume = {6},
year = {2019}
}
TY - JOUR
ID - 1605485
AU - Esteban-Gil, Angel - Perez-Sanz, Fernando - Garcia-Solano, Jose - Alburquerque-Gonzalez, Begona - Parreno-Gonzalez, Maria - Legaz-Garcia, Maria del Carmen - Fernandez-Breis, Jesualdo Tomas - Rodriguez-Braun, Edith - Pimentel, Paola - Tuomisto, Anne - Makinen, Markus - Slabý, Ondřej - Conesa-Zamora, Pablo
PY - 2019
TI - ColPortal, an integrative multiomic platform for analysing epigenetic interactions in colorectal cancer
JF - SCIENTIFIC DATA
VL - 6
IS - OCT 31 2019
SP - 1-14
EP - 1-14
PB - NATURE PUBLISHING GROUP
SN - 20524463
KW - MICROSATELLITE INSTABILITY
KW - PROMOTER HYPERMETHYLATION
KW - SERRATED POLYPS
KW - COLON-CANCER
KW - PHENOTYPE
KW - CARCINOGENESIS
KW - ADENOCARCINOMA
KW - BIOMARKERS
KW - PATHWAYS
KW - GENES
UR - https://www.nature.com/articles/s41597-019-0198-z.pdf
L2 - https://www.nature.com/articles/s41597-019-0198-z.pdf
N2 - Colorectal cancer (CRC) is the third leading cause of cancer mortality worldwide. Different pathological pathways and molecular drivers have been described and some of the associated markers are used to select effective anti-neoplastic therapy. More recent evidence points to a causal role of microbiota and altered microRNA expression in CRC carcinogenesis, but their relationship with pathological drivers or molecular phenotypes is not clearly established. Joint analysis of clinical and omics data can help clarify such relations. We present ColPortal, a platform that integrates transcriptomic, microtranscriptomic, methylomic and microbiota data of patients with colorectal cancer. ColPortal also includes detailed information of histological features and digital histological slides from the study cases, since histology is a morphological manifestation of a complex molecular change. The current cohort consists of Caucasian patients from Europe. For each patient, demographic information, location, histology, tumor staging, tissue prognostic factors, molecular biomarker status and clinical outcomes are integrated with omics data. ColPortal allows one to perform multiomics analyses for groups of patients selected by their clinical data.
ER -
ESTEBAN-GIL, Angel, Fernando PEREZ-SANZ, Jose GARCIA-SOLANO, Begona ALBURQUERQUE-GONZALEZ, Maria PARRENO-GONZALEZ, Maria del Carmen LEGAZ-GARCIA, Jesualdo Tomas FERNANDEZ-BREIS, Edith RODRIGUEZ-BRAUN, Paola PIMENTEL, Anne TUOMISTO, Markus MAKINEN, Ondřej SLABÝ a Pablo CONESA-ZAMORA. ColPortal, an integrative multiomic platform for analysing epigenetic interactions in colorectal cancer. \textit{SCIENTIFIC DATA}. LONDON: NATURE PUBLISHING GROUP, 2019, roč.~6, OCT 31 2019, s.~1-14. ISSN~2052-4463. Dostupné z: https://dx.doi.org/10.1038/s41597-019-0198-z.
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