Poor outcome in hypoxic endometrial carcinoma is related to
vascular density

J 2019

Poor outcome in hypoxic endometrial carcinoma is related to vascular density

REIJNEN, Casper, Willem Jan VAN WEELDEN, Martijn S. J. P. ARTS, Johan P. PETERS, Paul F. RIJKEN et. al.

Základní údaje

Originální název

Poor outcome in hypoxic endometrial carcinoma is related to vascular density

Autoři

REIJNEN, Casper (528 Nizozemské království, garant), Willem Jan VAN WEELDEN (528 Nizozemské království), Martijn S. J. P. ARTS (528 Nizozemské království), Johan P. PETERS (528 Nizozemské království), Paul F. RIJKEN (528 Nizozemské království), Koen VAN DE VIJVER (56 Belgie), Maria SANTACANA (724 Španělsko), Peter BRONSERT (276 Německo), Johan BULTEN (528 Nizozemské království), Marc HIRSCHFELD (276 Německo), Eva COLAS (724 Španělsko), Antonio GIL-MORENO (724 Španělsko), Armando REQUES (724 Španělsko), Gemma MANCEBO (724 Španělsko), Camilla KRAKSTAD (578 Norsko), Jone TROVIK (578 Norsko), Ingfrid S. HALDORSEN (578 Norsko), Jutta HUVILA (246 Finsko), Martin KOSKAS (250 Francie), Vít WEINBERGER (203 Česká republika, domácí), Luboš MINÁŘ (203 Česká republika, domácí), Eva JANDÁKOVÁ (203 Česká republika, domácí), Marc P. L. M. SNIJDERS (528 Nizozemské království), Saskia VAN DEN BERG-VAN ERP (528 Nizozemské království), Heidi V. N. KUSTERS-VANDEVELDE (528 Nizozemské království), Xavier MATIAS-GUIU (724 Španělsko), Frederic AMANT (56 Belgie), Leon F. A. G. MASSUGER (528 Nizozemské království), Johan BUSSINK (528 Nizozemské království) a Johanna M. A. PIJNENBORG (528 Nizozemské království)

Vydání

British journal of cancer, LONDON, NATURE PUBLISHING GROUP, 2019, 0007-0920

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.791

Kód RIV

RIV/00216224:14110/19:00112513

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41416-019-0461-2

UT WoS

000469218100004

Klíčová slova anglicky

CARBONIC-ANHYDRASE-IX; LYMPH-NODE METASTASIS; PROGNOSTIC-SIGNIFICANCE; MICROVESSEL DENSITY; INDUCIBLE FACTOR-1; SPACE INVASION; BREAST-CANCER; TUMOR HYPOXIA; EXPRESSION; ANGIOGENESIS

Štítky

14110230, 14110411, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 1. 2020 13:33, Mgr. Tereza Miškechová

Anotace

V originále

BACKGROUND: Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. METHODS: Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis. RESULTS: Sixty-three (16.4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0.002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3.71, p = 0.002), DDFS (HR 2.68, p = 0.009) and a trend for reduced DFS (HR 1.87, p = 0.054). CONCLUSIONS: This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients.

Citovat

REIJNEN, Casper, Willem Jan VAN WEELDEN, Martijn S. J. P. ARTS, Johan P. PETERS, Paul F. RIJKEN, Koen VAN DE VIJVER, Maria SANTACANA, Peter BRONSERT, Johan BULTEN, Marc HIRSCHFELD, Eva COLAS, Antonio GIL-MORENO, Armando REQUES, Gemma MANCEBO, Camilla KRAKSTAD, Jone TROVIK, Ingfrid S. HALDORSEN, Jutta HUVILA, Martin KOSKAS, Vít WEINBERGER, Luboš MINÁŘ, Eva JANDÁKOVÁ, Marc P. L. M. SNIJDERS, Saskia VAN DEN BERG-VAN ERP, Heidi V. N. KUSTERS-VANDEVELDE, Xavier MATIAS-GUIU, Frederic AMANT, Leon F. A. G. MASSUGER, Johan BUSSINK a Johanna M. A. PIJNENBORG. Poor outcome in hypoxic endometrial carcinoma is related to vascular density. British journal of cancer. LONDON: NATURE PUBLISHING GROUP, 2019, roč. 120, č. 11, s. 1037-1044. ISSN 0007-0920. Dostupné z: https://dx.doi.org/10.1038/s41416-019-0461-2.

@article{1605588,
   author = {Reijnen, Casper and van Weelden, Willem Jan and Arts, Martijn S. J. P. and Peters, Johan P. and Rijken, Paul F. and van de Vijver, Koen and Santacana, Maria and Bronsert, Peter and Bulten, Johan and Hirschfeld, Marc and Colas, Eva and GilandMoreno, Antonio and Reques, Armando and Mancebo, Gemma and Krakstad, Camilla and Trovik, Jone and Haldorsen, Ingfrid S. and Huvila, Jutta and Koskas, Martin and Weinberger, Vít and Minář, Luboš and Jandáková, Eva and Snijders, Marc P. L. M. and van den Bergandvan Erp, Saskia and KustersandVandevelde, Heidi V. N. and MatiasandGuiu, Xavier and Amant, Frederic and Massuger, Leon F. A. G. and Bussink, Johan and Pijnenborg, Johanna M. A.},
   article_location = {LONDON},
   article_number = {11},
   doi = {http://dx.doi.org/10.1038/s41416-019-0461-2},
   keywords = {CARBONIC-ANHYDRASE-IX; LYMPH-NODE METASTASIS; PROGNOSTIC-SIGNIFICANCE; MICROVESSEL DENSITY; INDUCIBLE FACTOR-1; SPACE INVASION; BREAST-CANCER; TUMOR HYPOXIA; EXPRESSION; ANGIOGENESIS},
   language = {eng},
   issn = {0007-0920},
   journal = {British journal of cancer},
   title = {Poor outcome in hypoxic endometrial carcinoma is related to vascular density},
   url = {http://dx.doi.org/10.1038/s41416-019-0461-2},
   volume = {120},
   year = {2019}
}

TY  - JOUR
ID  - 1605588
AU  - Reijnen, Casper - van Weelden, Willem Jan - Arts, Martijn S. J. P. - Peters, Johan P. - Rijken, Paul F. - van de Vijver, Koen - Santacana, Maria - Bronsert, Peter - Bulten, Johan - Hirschfeld, Marc - Colas, Eva - Gil-Moreno, Antonio - Reques, Armando - Mancebo, Gemma - Krakstad, Camilla - Trovik, Jone - Haldorsen, Ingfrid S. - Huvila, Jutta - Koskas, Martin - Weinberger, Vít - Minář, Luboš - Jandáková, Eva - Snijders, Marc P. L. M. - van den Berg-van Erp, Saskia - Kusters-Vandevelde, Heidi V. N. - Matias-Guiu, Xavier - Amant, Frederic - Massuger, Leon F. A. G. - Bussink, Johan - Pijnenborg, Johanna M. A.
PY  - 2019
TI  - Poor outcome in hypoxic endometrial carcinoma is related to vascular density
JF  - British journal of cancer
VL  - 120
IS  - 11
SP  - 1037-1044
EP  - 1037-1044
PB  - NATURE PUBLISHING GROUP
SN  - 00070920
KW  - CARBONIC-ANHYDRASE-IX
KW  - LYMPH-NODE METASTASIS
KW  - PROGNOSTIC-SIGNIFICANCE
KW  - MICROVESSEL DENSITY
KW  - INDUCIBLE FACTOR-1
KW  - SPACE INVASION
KW  - BREAST-CANCER
KW  - TUMOR HYPOXIA
KW  - EXPRESSION
KW  - ANGIOGENESIS
UR  - http://dx.doi.org/10.1038/s41416-019-0461-2
L2  - http://dx.doi.org/10.1038/s41416-019-0461-2
N2  - BACKGROUND: Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. METHODS: Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis. RESULTS: Sixty-three (16.4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0.002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3.71, p = 0.002), DDFS (HR 2.68, p = 0.009) and a trend for reduced DFS (HR 1.87, p = 0.054). CONCLUSIONS: This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients.
ER  -

REIJNEN, Casper, Willem Jan VAN WEELDEN, Martijn S. J. P. ARTS, Johan P. PETERS, Paul F. RIJKEN, Koen VAN DE VIJVER, Maria SANTACANA, Peter BRONSERT, Johan BULTEN, Marc HIRSCHFELD, Eva COLAS, Antonio GIL-MORENO, Armando REQUES, Gemma MANCEBO, Camilla KRAKSTAD, Jone TROVIK, Ingfrid S. HALDORSEN, Jutta HUVILA, Martin KOSKAS, Vít WEINBERGER, Luboš MINÁŘ, Eva JANDÁKOVÁ, Marc P. L. M. SNIJDERS, Saskia VAN DEN BERG-VAN ERP, Heidi V. N. KUSTERS-VANDEVELDE, Xavier MATIAS-GUIU, Frederic AMANT, Leon F. A. G. MASSUGER, Johan BUSSINK a Johanna M. A. PIJNENBORG. Poor outcome in hypoxic endometrial carcinoma is related to vascular density. \textit{British journal of cancer}. LONDON: NATURE PUBLISHING GROUP, 2019, roč.~120, č.~11, s.~1037-1044. ISSN~0007-0920. Dostupné z: https://dx.doi.org/10.1038/s41416-019-0461-2.

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