J 2019

Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study

ŠIPULA, David, Milan KOZÁK, Jaroslav SIPULA, Miroslav HOMZA, Jiri PLASEK et. al.

Základní údaje

Originální název

Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study

Autoři

ŠIPULA, David (203 Česká republika, garant, domácí), Milan KOZÁK (203 Česká republika, domácí), Jaroslav SIPULA (203 Česká republika), Miroslav HOMZA (203 Česká republika) a Jiri PLASEK (203 Česká republika)

Vydání

Open Medicine, Warsaw, Walter De Gruyter, 2019, 2391-5463

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 1.204

Kód RIV

RIV/00216224:14110/19:00112594

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

000501996200002

Klíčová slova anglicky

Cardiac Resynchronization Therapy; Heart Failure; Optimization; Speckle Tracking; Cardiac Strains

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 20. 1. 2020 07:59, Mgr. Tereza Miškechová

Anotace

V originále

Background. Approximately 30% of patients do not respond to implantation of Cardiac Resynchronization Therapy - Defibrillators (CRT-D). The aim of this study was to investigate the potential for cardiac strain speckle tracking to optimize the performance of CRT-D in non-responding patients. Methods. 30 patients not responding to Cardiac Resynchronization Therapy-Defibrillators after 3 months were randomly divided into control and intervention groups. Atrioventricular interval was adjusted so that E and A waves did not overlap, the interventricular interval was subsequently optimized to yield maximum improvement of the sum of longitudinal+radial+circumferential strains. The left ventricular ejection fraction (LVEF) and NYHA improvement 3 months after optimization were evaluated and use of other strain combinations assessed. Results. A significant correlation between the (combined) strain change and LVEF improvement was detected (p<0.01). 75% of patients with non-ischemic etiology of heart failure who did not respond to the original CRT-D reacted favorably with significant LVEF and NYHA improvement. The area strain was the best predictor of LVEF/NYHA improvement in those patients. No significant improvement was recorded in patients with ischemic etiology. Conclusions. AV and VV optimization based on speckle tracking is a very promising method potentially leading to a significant improvement of the outcome of CRT-D, especially in patients with non-ischemic etiology of heart failure.