Is Computer-Assisted Aminoglycoside Dosing Managed by a
Pharmacist a Safety Tool of Pharmacotherapy?

J 2019

Is Computer-Assisted Aminoglycoside Dosing Managed by a Pharmacist a Safety Tool of Pharmacotherapy?

DVORACKOVA, E., P. PAVEK, B. KOVACOVA, Jitka RYCHLÍČKOVÁ, O. SUCHOPAR et. al.

Základní údaje

Originální název

Is Computer-Assisted Aminoglycoside Dosing Managed by a Pharmacist a Safety Tool of Pharmacotherapy?

Autoři

DVORACKOVA, E. (203 Česká republika, garant), P. PAVEK (203 Česká republika), B. KOVACOVA (203 Česká republika), Jitka RYCHLÍČKOVÁ (203 Česká republika, domácí), O. SUCHOPAR (203 Česká republika), M. HOJNY (203 Česká republika), J. D. TEBBENS (203 Česká republika) a J. VLCEK (203 Česká republika)

Vydání

Physiological research, Praha, Fyziologický ústav AV ČR, 2019, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.655

Kód RIV

RIV/00216224:14110/19:00112619

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.33549/physiolres.934329

UT WoS

000499085100010

Klíčová slova anglicky

Therapeutic drug monitoring; Aminoglycosides; Pharmacist; Nephrotoxicity; Pharmacokinetics

Štítky

14110516, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 5. 2020 10:44, Mgr. Tereza Miškechová

Anotace

V originále

This pilot prospective study verified the hypothesis that use of computer-assisted therapeutic drug monitoring of aminoglycosides by pharmacists leads to better safety therapeutic outcomes and cost avoidance than only concentration measurement and dose adjustments based on a physician's experience. Two groups of patients were enrolled according to the technique of monitoring. Patients (Group 1, n=52) underwent monitoring by a pharmacist using pharmacokinetic software. In a control group (Group 2, n=11), plasma levels were measured but not interpreted by the pharmacist, only by physicians. No statistically significant differences were found between the groups in factors influenced by therapy. However, the results are not statistically significant but a comparison of the groups showed a clear trend towards safety and cost avoidance, thus supporting therapeutic drug monitoring. Safety limits were achieved in 76 % and 63 % of cases in Groups 1 and 2, respectively. More patients achieved both concentrations (peak and trough) with falling eGFR in Group 1. In present pilot study, the pharmacist improved the care of patients on aminoglycoside therapy. A larger study is needed to demonstrate statistically significantly improved safety and cost avoidance of aminoglycoside therapy monitoring by the pharmacist using pharmacokinetic software.

Citovat

DVORACKOVA, E., P. PAVEK, B. KOVACOVA, Jitka RYCHLÍČKOVÁ, O. SUCHOPAR, M. HOJNY, J. D. TEBBENS a J. VLCEK. Is Computer-Assisted Aminoglycoside Dosing Managed by a Pharmacist a Safety Tool of Pharmacotherapy? Physiological research. Praha: Fyziologický ústav AV ČR, 2019, roč. 68, Suppl. 1, s. "S87"-"S96", 10 s. ISSN 0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934329.

@article{1607015,
   author = {Dvorackova, E. and Pavek, P. and Kovacova, B. and Rychlíčková, Jitka and Suchopar, O. and Hojny, M. and Tebbens, J. D. and Vlcek, J.},
   article_location = {Praha},
   article_number = {Suppl. 1},
   doi = {http://dx.doi.org/10.33549/physiolres.934329},
   keywords = {Therapeutic drug monitoring; Aminoglycosides; Pharmacist; Nephrotoxicity; Pharmacokinetics},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological research},
   title = {Is Computer-Assisted Aminoglycoside Dosing Managed by a Pharmacist a Safety Tool of Pharmacotherapy?},
   url = {http://dx.doi.org/10.33549/physiolres.934329},
   volume = {68},
   year = {2019}
}

TY  - JOUR
ID  - 1607015
AU  - Dvorackova, E. - Pavek, P. - Kovacova, B. - Rychlíčková, Jitka - Suchopar, O. - Hojny, M. - Tebbens, J. D. - Vlcek, J.
PY  - 2019
TI  - Is Computer-Assisted Aminoglycoside Dosing Managed by a Pharmacist a Safety Tool of Pharmacotherapy?
JF  - Physiological research
VL  - 68
IS  - Suppl. 1
SP  - "S87"-"S96"
EP  - "S87"-"S96"
PB  - Fyziologický ústav AV ČR
SN  - 08628408
KW  - Therapeutic drug monitoring
KW  - Aminoglycosides
KW  - Pharmacist
KW  - Nephrotoxicity
KW  - Pharmacokinetics
UR  - http://dx.doi.org/10.33549/physiolres.934329
L2  - http://dx.doi.org/10.33549/physiolres.934329
N2  - This pilot prospective study verified the hypothesis that use of computer-assisted therapeutic drug monitoring of aminoglycosides by pharmacists leads to better safety therapeutic outcomes and cost avoidance than only concentration measurement and dose adjustments based on a physician's experience. Two groups of patients were enrolled according to the technique of monitoring. Patients (Group 1, n=52) underwent monitoring by a pharmacist using pharmacokinetic software. In a control group (Group 2, n=11), plasma levels were measured but not interpreted by the pharmacist, only by physicians. No statistically significant differences were found between the groups in factors influenced by therapy. However, the results are not statistically significant but a comparison of the groups showed a clear trend towards safety and cost avoidance, thus supporting therapeutic drug monitoring. Safety limits were achieved in 76 % and 63 % of cases in Groups 1 and 2, respectively. More patients achieved both concentrations (peak and trough) with falling eGFR in Group 1. In present pilot study, the pharmacist improved the care of patients on aminoglycoside therapy. A larger study is needed to demonstrate statistically significantly improved safety and cost avoidance of aminoglycoside therapy monitoring by the pharmacist using pharmacokinetic software.
ER  -

DVORACKOVA, E., P. PAVEK, B. KOVACOVA, Jitka RYCHLÍČKOVÁ, O. SUCHOPAR, M. HOJNY, J. D. TEBBENS a J. VLCEK. Is Computer-Assisted Aminoglycoside Dosing Managed by a Pharmacist a Safety Tool of Pharmacotherapy? \textit{Physiological research}. Praha: Fyziologický ústav AV ČR, 2019, roč.~68, Suppl. 1, s.~''S87''-''S96'', 10 s. ISSN~0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934329.

Podrobný výpis o publikaci