SALMANTON-GARCIA, Jon, Danila SEIDEL, Philipp KOEHLER, Sibylle C. MELLINGHOFF, Raoul HERBRECHT, Nikolai KLIMKO, Zdeněk RÁČIL, Iker FALCES-ROMERO, Paul INGRAM, Angel BENITEZ-PENUELA, Jose RODRIGUEZ, Guillaume DESOUBEAUX, Aleksandra BARAC, Carolina GARCIA-VIDAL, Martin HOENIGL, Sanjay R. MEHTA, Matthew P. CHENG, Galina KLYASOVA, Werner J. HEINZ, Nousheen IQBAL, Robert KRAUSE, Helmut OSTERMANN, Olaf PENACK, Enrico SCHALK, Donald C. SHEPPARD, Birgit WILLINGER, Hilmar WISPLINGHOFF a J. Janne VEHRESCHILD. Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn). Journal of Antimicrobial Chemotherapy. OXFORD: Oxford University Press, 2019, roč. 74, č. 11, s. 3315-3327. ISSN 0305-7453. Dostupné z: https://dx.doi.org/10.1093/jac/dkz344. |
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@article{1607046, author = {SalmantonandGarcia, Jon and Seidel, Danila and Koehler, Philipp and Mellinghoff, Sibylle C. and Herbrecht, Raoul and Klimko, Nikolai and Ráčil, Zdeněk and FalcesandRomero, Iker and Ingram, Paul and BenitezandPenuela, Angel and Rodriguez, Jose and Desoubeaux, Guillaume and Barac, Aleksandra and GarciaandVidal, Carolina and Hoenigl, Martin and Mehta, Sanjay R. and Cheng, Matthew P. and Klyasova, Galina and Heinz, Werner J. and Iqbal, Nousheen and Krause, Robert and Ostermann, Helmut and Penack, Olaf and Schalk, Enrico and Sheppard, Donald C. and Willinger, Birgit and Wisplinghoff, Hilmar and Vehreschild, J. Janne}, article_location = {OXFORD}, article_number = {11}, doi = {http://dx.doi.org/10.1093/jac/dkz344}, keywords = {LIPOSOMAL AMPHOTERICIN-B; MYCOSES STUDY-GROUP; TRANSPLANT RECIPIENTS; EUROPEAN-ORGANIZATION; TABLET FORMULATION; FUNGAL-INFECTIONS; ORAL TABLET; PHARMACOKINETICS; THERAPY; SAFETY}, language = {eng}, issn = {0305-7453}, journal = {Journal of Antimicrobial Chemotherapy}, title = {Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn)}, url = {http://dx.doi.org/10.1093/jac/dkz344}, volume = {74}, year = {2019} }
TY - JOUR ID - 1607046 AU - Salmanton-Garcia, Jon - Seidel, Danila - Koehler, Philipp - Mellinghoff, Sibylle C. - Herbrecht, Raoul - Klimko, Nikolai - Ráčil, Zdeněk - Falces-Romero, Iker - Ingram, Paul - Benitez-Penuela, Angel - Rodriguez, Jose - Desoubeaux, Guillaume - Barac, Aleksandra - Garcia-Vidal, Carolina - Hoenigl, Martin - Mehta, Sanjay R. - Cheng, Matthew P. - Klyasova, Galina - Heinz, Werner J. - Iqbal, Nousheen - Krause, Robert - Ostermann, Helmut - Penack, Olaf - Schalk, Enrico - Sheppard, Donald C. - Willinger, Birgit - Wisplinghoff, Hilmar - Vehreschild, J. Janne PY - 2019 TI - Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn) JF - Journal of Antimicrobial Chemotherapy VL - 74 IS - 11 SP - 3315-3327 EP - 3315-3327 PB - Oxford University Press SN - 03057453 KW - LIPOSOMAL AMPHOTERICIN-B KW - MYCOSES STUDY-GROUP KW - TRANSPLANT RECIPIENTS KW - EUROPEAN-ORGANIZATION KW - TABLET FORMULATION KW - FUNGAL-INFECTIONS KW - ORAL TABLET KW - PHARMACOKINETICS KW - THERAPY KW - SAFETY UR - http://dx.doi.org/10.1093/jac/dkz344 L2 - http://dx.doi.org/10.1093/jac/dkz344 N2 - Background: First-line antifungal treatment for invasive mucormycosis (IM) consists of liposomal amphotericin B. Salvage treatment options are limited and often based on posaconazole oral suspension. With the approval of posaconazole new formulations, patients could benefit from improved pharmacokinetics, safety and tolerability. Objectives: Our aim was to assess the effectiveness of posaconazole new formulations for IM treatment. Methods: We performed a case-matched analysis with proven or probable IM patients from the FungiScope (R) Registry. First-line posaconazole new formulations (1st-POSnew) and first-line amphotericin B plus posaconazole new formulations (1st-AMB+POSnew) cases were matched with first-line amphotericin B-based (1st-AMB) treatment controls. Salvage posaconazole new formulations (SAL-POSnew) cases were matched with salvage posaconazole oral suspension (SAL-POSsusp) controls. Each case was matched with up to three controls (based on severity, haematological/oncological malignancy, surgery and/or renal dysfunction). Results: Five patients receiving 1st-POSnew, 18 receiving 1st-AMB+POSnew and 22 receiving SAL-POSnew were identified. By day 42, a favourable response was reported for 80.0% (n=4/5) of patients receiving 1st-POSnew, for 27.8% (n=5/18) receiving 1st-AMB+POSnew and for 50.0% (n=11/22) receiving SAL-POSnew. Day 42 all-cause mortality of patients receiving posaconazole new formulations was lower compared with controls [20.0% (n=1/5) in 1st-POSnew versus 53.3% (n=8/15) in 1st-AMB; 33.3% (n=6/18) in 1st-AMB+POSnew versus 52.0% (n=26/50) in 1st-AMB; and 0.0% (n=0/22) in SAL-POSnew versus 4.4% (n=2/45) in SAL-POSsusp]. Conclusions: Posaconazole new formulations were effective in terms of treatment response and associated mortality of IM. While posaconazole new formulations may be an alternative for treatment of IM, the limited sample size of our study calls for a cautious interpretation of these observations. ER -
SALMANTON-GARCIA, Jon, Danila SEIDEL, Philipp KOEHLER, Sibylle C. MELLINGHOFF, Raoul HERBRECHT, Nikolai KLIMKO, Zdeněk RÁČIL, Iker FALCES-ROMERO, Paul INGRAM, Angel BENITEZ-PENUELA, Jose RODRIGUEZ, Guillaume DESOUBEAUX, Aleksandra BARAC, Carolina GARCIA-VIDAL, Martin HOENIGL, Sanjay R. MEHTA, Matthew P. CHENG, Galina KLYASOVA, Werner J. HEINZ, Nousheen IQBAL, Robert KRAUSE, Helmut OSTERMANN, Olaf PENACK, Enrico SCHALK, Donald C. SHEPPARD, Birgit WILLINGER, Hilmar WISPLINGHOFF a J. Janne VEHRESCHILD. Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn). \textit{Journal of Antimicrobial Chemotherapy}. OXFORD: Oxford University Press, 2019, roč.~74, č.~11, s.~3315-3327. ISSN~0305-7453. Dostupné z: https://dx.doi.org/10.1093/jac/dkz344.
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