Baroreflex sensitivity is associated with post-stroke
infections. An open, prospective study

J 2019

Baroreflex sensitivity is associated with post-stroke infections. An open, prospective study

SYKORA, Marek, Pavel SIARNIK, Jozef SZABO, Peter TURCANI, Stefan KREBS et. al.

Základní údaje

Originální název

Baroreflex sensitivity is associated with post-stroke infections. An open, prospective study

Autoři

SYKORA, Marek (40 Rakousko, garant), Pavel SIARNIK (703 Slovensko), Jozef SZABO (703 Slovensko), Peter TURCANI (703 Slovensko), Stefan KREBS (40 Rakousko), Wilfried LANG (40 Rakousko), Stanislava JAKUBÍČEK (703 Slovensko, domácí), Marek CZOSNYKA (616 Polsko) a Peter SMIELEWSKI (616 Polsko)

Vydání

Journal of the neurological sciences, Amsterdam, Elsevier, 2019, 0022-510X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.115

Kód RIV

RIV/00216224:14110/19:00112623

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.jns.2019.116450

UT WoS

000499766400015

Klíčová slova anglicky

Baroreflex; Stroke; Infection; Pneumonia; Autonomic

Štítky

14110127, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 1. 2020 13:09, Mgr. Tereza Miškechová

Anotace

V originále

Background and purpose: Autonomic nervous system (ANS) seems to play an important role in the post-stroke immunosuppression syndrome with increased susceptibility to infections. The aim of this study was to investigate if ANS activity measured at admission is associated with post-stroke infections. Methods: We prospectively analyzed patients with acute ischemic stroke. ANS was measured using the cross-correlational baroreflex sensitivity (BRS) at admission. The occurrence and cause of in-hospital infections was assessed based on the clinical and laboratory examination. Demographic and clinical variables including initial stroke severity, dysphagia, procedures as nasogastric tubes, central venous and urinary catheters and mechanical ventilation were included in the analysis. Results: We included 161 patients with ischemic stroke, of those 49 (30.4%) developed a nosocomial infection during the first 7 days of hospital stay. Patients with infections had significantly lower BRS (median 3 vs 5 ms/mmHg, p<.001) higher initial NIHSS (median 15 vs 5, p<.001), had more often non-lacunar etiology and underwent more invasive procedures. In the multivariable regression model decreased BRS (adjusted OR 1.21, 95% CI 1.03-1.41, p=.02), admission NIHSS (adjusted OR 1.10, 95% CI 1.02-1.19, p=.02) and invasive procedures (adjusted OR 1.46, 95% CI 1.03-2.06, p=.03) were independently associated with infection after ischemic stroke. Conclusions: Decreased BRS was independently associated with infections after ischemic stroke. Autonomic shift may play an important role in increased susceptibility to infections after stroke. The possible diagnostic and therapeutic relevance of this finding deserves further research.

Citovat

SYKORA, Marek, Pavel SIARNIK, Jozef SZABO, Peter TURCANI, Stefan KREBS, Wilfried LANG, Stanislava JAKUBÍČEK, Marek CZOSNYKA a Peter SMIELEWSKI. Baroreflex sensitivity is associated with post-stroke infections. An open, prospective study. Journal of the neurological sciences. Amsterdam: Elsevier, 2019, roč. 406, NOV 15 2019, s. 1-5. ISSN 0022-510X. Dostupné z: https://dx.doi.org/10.1016/j.jns.2019.116450.

@article{1607058,
   author = {Sykora, Marek and Siarnik, Pavel and Szabo, Jozef and Turcani, Peter and Krebs, Stefan and Lang, Wilfried and Jakubíček, Stanislava and Czosnyka, Marek and Smielewski, Peter},
   article_location = {Amsterdam},
   article_number = {NOV 15 2019},
   doi = {http://dx.doi.org/10.1016/j.jns.2019.116450},
   keywords = {Baroreflex; Stroke; Infection; Pneumonia; Autonomic},
   language = {eng},
   issn = {0022-510X},
   journal = {Journal of the neurological sciences},
   title = {Baroreflex sensitivity is associated with post-stroke infections. An open, prospective study},
   url = {http://dx.doi.org/10.1016/j.jns.2019.116450},
   volume = {406},
   year = {2019}
}

TY  - JOUR
ID  - 1607058
AU  - Sykora, Marek - Siarnik, Pavel - Szabo, Jozef - Turcani, Peter - Krebs, Stefan - Lang, Wilfried - Jakubíček, Stanislava - Czosnyka, Marek - Smielewski, Peter
PY  - 2019
TI  - Baroreflex sensitivity is associated with post-stroke infections. An open, prospective study
JF  - Journal of the neurological sciences
VL  - 406
IS  - NOV 15 2019
SP  - 1-5
EP  - 1-5
PB  - Elsevier
SN  - 0022510X
KW  - Baroreflex
KW  - Stroke
KW  - Infection
KW  - Pneumonia
KW  - Autonomic
UR  - http://dx.doi.org/10.1016/j.jns.2019.116450
L2  - http://dx.doi.org/10.1016/j.jns.2019.116450
N2  - Background and purpose: Autonomic nervous system (ANS) seems to play an important role in the post-stroke immunosuppression syndrome with increased susceptibility to infections. The aim of this study was to investigate if ANS activity measured at admission is associated with post-stroke infections. Methods: We prospectively analyzed patients with acute ischemic stroke. ANS was measured using the cross-correlational baroreflex sensitivity (BRS) at admission. The occurrence and cause of in-hospital infections was assessed based on the clinical and laboratory examination. Demographic and clinical variables including initial stroke severity, dysphagia, procedures as nasogastric tubes, central venous and urinary catheters and mechanical ventilation were included in the analysis. Results: We included 161 patients with ischemic stroke, of those 49 (30.4%) developed a nosocomial infection during the first 7 days of hospital stay. Patients with infections had significantly lower BRS (median 3 vs 5 ms/mmHg, p<.001) higher initial NIHSS (median 15 vs 5, p<.001), had more often non-lacunar etiology and underwent more invasive procedures. In the multivariable regression model decreased BRS (adjusted OR 1.21, 95% CI 1.03-1.41, p=.02), admission NIHSS (adjusted OR 1.10, 95% CI 1.02-1.19, p=.02) and invasive procedures (adjusted OR 1.46, 95% CI 1.03-2.06, p=.03) were independently associated with infection after ischemic stroke. Conclusions: Decreased BRS was independently associated with infections after ischemic stroke. Autonomic shift may play an important role in increased susceptibility to infections after stroke. The possible diagnostic and therapeutic relevance of this finding deserves further research.
ER  -

SYKORA, Marek, Pavel SIARNIK, Jozef SZABO, Peter TURCANI, Stefan KREBS, Wilfried LANG, Stanislava JAKUBÍČEK, Marek CZOSNYKA a Peter SMIELEWSKI. Baroreflex sensitivity is associated with post-stroke infections. An open, prospective study. \textit{Journal of the neurological sciences}. Amsterdam: Elsevier, 2019, roč.~406, NOV 15 2019, s.~1-5. ISSN~0022-510X. Dostupné z: https://dx.doi.org/10.1016/j.jns.2019.116450.

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