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@article{1607099, author = {Moutelíková, Romana and Sauer, Pavel and Dvořáková Heroldová, Monika and Holá, Veronika and Prodělalová, Jana}, article_location = {BASEL}, article_number = {11}, doi = {http://dx.doi.org/10.3390/v11111015}, keywords = {rotavirus A; G8; gastroenteritis; bovine-human reassortants; Central Europe}, language = {eng}, issn = {1999-4915}, journal = {VIRUSES-BASEL}, title = {Emergence of Rare Bovine-Human Reassortant DS-1-Like Rotavirus A Strains with G8P[8] Genotype in Human Patients in the Czech Republic}, url = {http://dx.doi.org/10.3390/v11111015}, volume = {11}, year = {2019} }
TY - JOUR ID - 1607099 AU - Moutelíková, Romana - Sauer, Pavel - Dvořáková Heroldová, Monika - Holá, Veronika - Prodělalová, Jana PY - 2019 TI - Emergence of Rare Bovine-Human Reassortant DS-1-Like Rotavirus A Strains with G8P[8] Genotype in Human Patients in the Czech Republic JF - VIRUSES-BASEL VL - 11 IS - 11 SP - 1-14 EP - 1-14 PB - MDPI AG SN - 19994915 KW - rotavirus A KW - G8 KW - gastroenteritis KW - bovine-human reassortants KW - Central Europe UR - http://dx.doi.org/10.3390/v11111015 L2 - http://dx.doi.org/10.3390/v11111015 N2 - Group A Rotaviruses (RVA) are the leading cause of acute gastroenteritis in children and a major cause of childhood mortality in low-income countries. RVAs are mostly host-specific, but interspecies transmission and reassortment between human and animal RVAs significantly contribute to their genetic diversity. We investigated the VP7 and VP4 genotypes of RVA isolated from 225 stool specimens collected from Czech patients with gastroenteritis during 2016-2019. The most abundant genotypes were G1P[8] (42.7%), G3P[8] (11.1%), G9P[8] (9.8%), G2P[4] (4.4%), G4P[8] (1.3%), G12P[8] (1.3%), and, surprisingly, G8P[8] (9.3%). Sequence analysis of G8P[8] strains revealed the highest nucleotide similarity of all Czech G8 sequences to the G8P[8] rotavirus strains that were isolated in Vietnam in 2014/2015. The whole-genome backbone of the Czech G8 strains was determined with the use of next-generation sequencing as DS-1-like. Phylogenetic analysis of all segments clustered the Czech isolates with RVA strains that were formerly described in Southeast Asia, which had emerged following genetic reassortment between bovine and human RVAs. This is the first time that bovine-human DS-1-like G8P[8] strains were detected at a high rate in human patients in Central Europe. Whether the emergence of this unusual genotype reflects the establishment of a new RVA strain in the population requires the continuous monitoring of rotavirus epidemiology. ER -
MOUTELÍKOVÁ, Romana, Pavel SAUER, Monika DVOŘÁKOVÁ HEROLDOVÁ, Veronika HOLÁ a Jana PRODĚLALOVÁ. Emergence of Rare Bovine-Human Reassortant DS-1-Like Rotavirus A Strains with G8P[8] Genotype in Human Patients in the Czech Republic. \textit{VIRUSES-BASEL}. BASEL: MDPI AG, 2019, roč.~11, č.~11, s.~1-14. ISSN~1999-4915. Dostupné z: https://dx.doi.org/10.3390/v11111015.
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