Automated Annotation of Secondary Structure Elements for Entire
Protein Families

a 2018

Automated Annotation of Secondary Structure Elements for Entire Protein Families

MIDLIK, Adam, Ivana HUTAŘOVÁ VAŘEKOVÁ, Jan HUTAŘ, Tarakaramji MOTURU, Veronika NAVRÁTILOVÁ et. al.

Základní údaje

Originální název

Automated Annotation of Secondary Structure Elements for Entire Protein Families

Autoři

MIDLIK, Adam, Ivana HUTAŘOVÁ VAŘEKOVÁ, Jan HUTAŘ, Tarakaramji MOTURU, Veronika NAVRÁTILOVÁ, Radka SVOBODOVÁ VAŘEKOVÁ, Jaroslav KOČA a Karel BERKA

Vydání

National Bioinformatic Conference ENBIK, 2018

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Organizační jednotka

Přírodovědecká fakulta

Změněno: 22. 1. 2020 13:45, Mgr. et Mgr. Adam Midlik, Ph.D.

Anotace

V originále

Protein structural data, deposited in Protein Data Bank, represent a highly valuable source of information and their amount is continuously growing. Currently, the data contain more and more structurally and functionally similar proteins (so called protein families), which originate from various organisms, contain different ligands, or have various mutations. To analyse and examine these data, we must identify comparable and related regions in different proteins from one protein family. A part of this process is annotation of protein secondary structure elements (SSEs), which form stable parts of the protein and help us to localize the key regions. Since an automated procedure for SSEs annotation is not available yet, we developed such an approach [1]. Our method is template-based, meaning that an annotation of a template protein from the family is provided as an input to the algorithm together with a set of query proteins (the whole family). A three-step algorithm is then executed on each query protein. In the first step, SSEs are detected in the query protein. The second step is structural alignment and superimposition of the query protein and the template protein, so the corresponding parts of the two proteins are located close to each other. The third step is the selection of those SSEs from the query protein which are the best counterparts for the SSEs in the template protein. [1] Svobodová Vařeková, R., Midlik, A., Hutařová Vařeková, I., Hutař, J., Navrátilová, V., Koča, J., Berka, K. (2018). Secondary Structure Elements-Annotations and Schematic 2D Visualizations Stable for Individual Protein Families. Biophysical Journal, 114(3), 46a-47a.

Citovat

MIDLIK, Adam, Ivana HUTAŘOVÁ VAŘEKOVÁ, Jan HUTAŘ, Tarakaramji MOTURU, Veronika NAVRÁTILOVÁ, Radka SVOBODOVÁ VAŘEKOVÁ, Jaroslav KOČA a Karel BERKA. Automated Annotation of Secondary Structure Elements for Entire Protein Families. In National Bioinformatic Conference ENBIK. 2018.

@proceedings{1608524,
   author = {Midlik, Adam and Hutařová Vařeková, Ivana and Hutař, Jan and Moturu, Tarakaramji and Navrátilová, Veronika and Svobodová Vařeková, Radka and Koča, Jaroslav and Berka, Karel},
   booktitle = {National Bioinformatic Conference ENBIK},
   language = {eng},
   title = {Automated Annotation of Secondary Structure Elements for Entire Protein Families},
   url = {http://www.enbik.cz/enbik2018/},
   year = {2018}
}

TY  - CONF
ID  - 1608524
AU  - Midlik, Adam - Hutařová Vařeková, Ivana - Hutař, Jan - Moturu, Tarakaramji - Navrátilová, Veronika - Svobodová Vařeková, Radka - Koča, Jaroslav - Berka, Karel
PY  - 2018
TI  - Automated Annotation of Secondary Structure Elements for Entire Protein Families
UR  - http://www.enbik.cz/enbik2018/
N2  - Protein structural data, deposited in Protein Data Bank, represent a highly valuable source of information and their amount is continuously growing. Currently, the data contain more and more structurally and functionally similar proteins (so called protein families), which originate from various organisms, contain different ligands, or have various mutations. To analyse and examine these data, we must identify comparable and related regions in different proteins from one protein family. A part of this process is annotation of protein secondary structure elements (SSEs), which form stable parts of the protein and help us to localize the key regions. Since an automated procedure for SSEs annotation is not available yet, we developed such an approach [1]. Our method is template-based, meaning that an annotation of a template protein from the family is provided as an input to the algorithm together with a set of query proteins (the whole family). A three-step algorithm is then executed on each query protein. In the first step, SSEs are detected in the query protein. The second step is structural alignment and superimposition of the query protein and the template protein, so the corresponding parts of the two proteins are located close to each other. The third step is the selection of those SSEs from the query protein which are the best counterparts for the SSEs in the template protein. [1] Svobodová Vařeková, R., Midlik, A., Hutařová Vařeková, I., Hutař, J., Navrátilová, V., Koča, J., Berka, K. (2018). Secondary Structure Elements-Annotations and Schematic 2D Visualizations Stable for Individual Protein Families. Biophysical Journal, 114(3), 46a-47a.
ER  -

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