Architecture and Evolution of Blade Assembly in beta-propeller
Lectins

J 2019

Architecture and Evolution of Blade Assembly in beta-propeller Lectins

BONNARDEL, Francois, Atul KUMAR, Michaela WIMMEROVÁ, Martina LAHMANN, Serge PEREZ et. al.

Základní údaje

Originální název

Architecture and Evolution of Blade Assembly in beta-propeller Lectins

Autoři

BONNARDEL, Francois (250 Francie), Atul KUMAR (356 Indie, domácí), Michaela WIMMEROVÁ (203 Česká republika, garant, domácí), Martina LAHMANN (752 Švédsko), Serge PEREZ (250 Francie), Annabelle VARROT (250 Francie), Frederique LISACEK (756 Švýcarsko) a Anne IMBERTY (250 Francie)

Vydání

Structure, CAMBRIDGE, CELL PRESS, 2019, 0969-2126

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10400 1.4 Chemical sciences

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.862

Kód RIV

RIV/00216224:14310/19:00108109

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.str.2019.02.002

UT WoS

000467238900006

Klíčová slova anglicky

lectin; beta-propellers

Štítky

BISON, CF BIC, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 10. 2024 14:59, Ing. Martina Blahová

Anotace

V originále

Lectins with a beta-propeller fold bind glycans on the cell surface through multivalent binding sites and appropriate directionality. These proteins are formed by repeats of short domains, raising questions about evolutionary duplication. However, these repeats are difficult to detect in translated genomes and seldom correctly annotated in sequence databases. To address these issues, we defined the blade signature of the five types of beta-propellers using 3D-structural data. With these templates, we predicted 3,887 beta-propeller lectins in 1,889 species and organized this information in a searchable online database. The data reveal a widespread distribution of beta-propeller lectins across species. Prediction also emphasizes multiple architectures and led to the discovery of a beta-propeller assembly scenario. This was confirmed by producing and characterizing a predicted protein coded in the genome of Kordia zhangzhouensis. The crystal structure uncovers an intermediate in the evolution of beta-propeller assembly and demonstrates the power of our tools.

Návaznosti

GA18-18964S, projekt VaV

Název: Lektiny a jejich úloha v interakci patogen/hostitel a buněčném rozpoznávání

Investor: Grantová agentura ČR, Lektiny a jejich úloha v interakci patogen/hostitel a buněčném rozpoznávání

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

692068, interní kód MU

Název: BISON - Bridging Structural Biology with Biological Synthesis and Self Assembly to Reveal Key Processes in Living Systems (Akronym: BISON)

Investor: Evropská unie, BISON - Bridging Structural Biology with Biological Synthesis and Self Assembly to Reveal Key Processes in Living Systems, Spreading excellence and widening participation

90043, velká výzkumná infrastruktura

Název: CIISB

Citovat

BONNARDEL, Francois, Atul KUMAR, Michaela WIMMEROVÁ, Martina LAHMANN, Serge PEREZ, Annabelle VARROT, Frederique LISACEK a Anne IMBERTY. Architecture and Evolution of Blade Assembly in beta-propeller Lectins. Structure. CAMBRIDGE: CELL PRESS, 2019, roč. 27, č. 5, s. 764-775. ISSN 0969-2126. Dostupné z: https://dx.doi.org/10.1016/j.str.2019.02.002.

@article{1608896,
   author = {Bonnardel, Francois and Kumar, Atul and Wimmerová, Michaela and Lahmann, Martina and Perez, Serge and Varrot, Annabelle and Lisacek, Frederique and Imberty, Anne},
   article_location = {CAMBRIDGE},
   article_number = {5},
   doi = {http://dx.doi.org/10.1016/j.str.2019.02.002},
   keywords = {lectin; beta-propellers},
   language = {eng},
   issn = {0969-2126},
   journal = {Structure},
   title = {Architecture and Evolution of Blade Assembly in beta-propeller Lectins},
   url = {https://www.sciencedirect.com/science/article/abs/pii/S0969212619300462?via%3Dihub},
   volume = {27},
   year = {2019}
}

TY  - JOUR
ID  - 1608896
AU  - Bonnardel, Francois - Kumar, Atul - Wimmerová, Michaela - Lahmann, Martina - Perez, Serge - Varrot, Annabelle - Lisacek, Frederique - Imberty, Anne
PY  - 2019
TI  - Architecture and Evolution of Blade Assembly in beta-propeller Lectins
JF  - Structure
VL  - 27
IS  - 5
SP  - 764-775
EP  - 764-775
PB  - CELL PRESS
SN  - 09692126
KW  - lectin
KW  - beta-propellers
UR  - https://www.sciencedirect.com/science/article/abs/pii/S0969212619300462?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/abs/pii/S0969212619300462?via%3Dihub
N2  - Lectins with a beta-propeller fold bind glycans on the cell surface through multivalent binding sites and appropriate directionality. These proteins are formed by repeats of short domains, raising questions about evolutionary duplication. However, these repeats are difficult to detect in translated genomes and seldom correctly annotated in sequence databases. To address these issues, we defined the blade signature of the five types of beta-propellers using 3D-structural data. With these templates, we predicted 3,887 beta-propeller lectins in 1,889 species and organized this information in a searchable online database. The data reveal a widespread distribution of beta-propeller lectins across species. Prediction also emphasizes multiple architectures and led to the discovery of a beta-propeller assembly scenario. This was confirmed by producing and characterizing a predicted protein coded in the genome of Kordia zhangzhouensis. The crystal structure uncovers an intermediate in the evolution of beta-propeller assembly and demonstrates the power of our tools.
ER  -

BONNARDEL, Francois, Atul KUMAR, Michaela WIMMEROVÁ, Martina LAHMANN, Serge PEREZ, Annabelle VARROT, Frederique LISACEK a Anne IMBERTY. Architecture and Evolution of Blade Assembly in beta-propeller Lectins. \textit{Structure}. CAMBRIDGE: CELL PRESS, 2019, roč.~27, č.~5, s.~764-775. ISSN~0969-2126. Dostupné z: https://dx.doi.org/10.1016/j.str.2019.02.002.

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