Sensory profiles and immune-related expression patterns of
patients with and without neuropathic pain after peripheral
nerve lesion

J 2019

Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion

HELD, Melissa, Franziska KARL, Eva VLČKOVÁ, Aneta RAJDOVÁ, Fabiola ESCOLANO-LOZANO et. al.

Základní údaje

Originální název

Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion

Autoři

HELD, Melissa (276 Německo), Franziska KARL (276 Německo), Eva VLČKOVÁ (203 Česká republika, domácí), Aneta RAJDOVÁ (203 Česká republika, domácí), Fabiola ESCOLANO-LOZANO (276 Německo), Christian STETTER (276 Německo), Richa BHARTI (276 Německo), Konrad U. FÖRSTNER (276 Německo), Ladislav DUŠEK (203 Česká republika, domácí), Mathias LEINDERS (276 Německo), Frank BIRKLEIN (276 Německo), Josef BEDNAŘÍK (203 Česká republika, domácí), Claudia SOMMER (276 Německo) a Nurcan ÜÇEYLER (garant)

Vydání

Pain, LIPPINCOTT WILLIAMS & WILKINS, 2019, 0304-3959

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.483

Kód RIV

RIV/00216224:14110/19:00112744

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1097/j.pain.0000000000001623

UT WoS

000512905700016

Klíčová slova anglicky

Nerve lesion; Neuropathic pain; Sensory profile; Quantitative sensory testing; mRNA

Štítky

14110221, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 3. 2020 08:52, Mgr. Tereza Miškechová

Anotace

V originále

In this multicenter cross-sectional study, we determined sensory profiles of patients with (NL-1) and without neuropathic pain (NL-0) after nerve lesion and assessed immune-related systemic gene expression. Patients and matched healthy controls filled in questionnaires and underwent neurological examination, neurophysiological studies, quantitative sensory testing, and blood withdrawal. Neuropathic pain was present in 67/95 (71%) patients (NL-1). Tactile hyperalgesia was the most prominent clinical sign in NL-1 patients (P , 0.05). Questionnaires showed an association between neuropathic pain and the presence of depression, anxiety, and catastrophizing (P , 0.05 to P , 0.01). Neuropathic pain was frequently accompanied by other chronic pain (P , 0.05). Quantitative sensory testing showed ipsilateral signs of small and large fiber impairment compared to the respective contralateral side, with elevated thermal and mechanical detection thresholds (P , 0.001 to P , 0.05) and lowered pressure pain threshold (P , 0.05). Also, more loss of function was found in patients with NL-1 compared to NL-0. Pain intensity was associated with mechanical hyperalgesia (P , 0.05 to P , 0.01). However, quantitative sensory testing did not detect or predict neuropathic pain. Gene expression of peptidylglycine a-amidating monooxygenase was higher in NL patients compared with healthy controls (NL-1, P , 0.01; NL-0, P , 0.001). Also, gene expression of tumor necrosis factor-a was higher in NL-1 patients compared with NL-0 (P , 0.05), and interleukin-1ß was higher, but IL-10 was lower in NL-1 patients compared with healthy controls (P , 0.05 each). Our study reveals that nerve lesion presents with small and large nerve fiber dysfunction, which may contribute to the presence and intensity of neuropathic pain and which is associated with a systemic proinflammatory pattern.

Návaznosti

MUNI/A/1419/2018, interní kód MU

Název: Diagnostika a patofyziologie neuropatické bolesti (Akronym: PNB)

Investor: Masarykova univerzita, Diagnostika a patofyziologie neuropatické bolesti, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

602133, interní kód MU

Název: ncRNAPain - Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (Akronym: ncRNAPain)

Investor: Evropská unie, ncRNAPain - Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine, Spolupráce

Citovat

HELD, Melissa, Franziska KARL, Eva VLČKOVÁ, Aneta RAJDOVÁ, Fabiola ESCOLANO-LOZANO, Christian STETTER, Richa BHARTI, Konrad U. FÖRSTNER, Ladislav DUŠEK, Mathias LEINDERS, Frank BIRKLEIN, Josef BEDNAŘÍK, Claudia SOMMER a Nurcan ÜÇEYLER. Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion. Pain. LIPPINCOTT WILLIAMS & WILKINS, 2019, roč. 160, č. 10, s. 2316-2327. ISSN 0304-3959. Dostupné z: https://dx.doi.org/10.1097/j.pain.0000000000001623.

@article{1609602,
   author = {Held, Melissa and Karl, Franziska and Vlčková, Eva and Rajdová, Aneta and EscolanoandLozano, Fabiola and Stetter, Christian and Bharti, Richa and Förstner, Konrad U. and Dušek, Ladislav and Leinders, Mathias and Birklein, Frank and Bednařík, Josef and Sommer, Claudia and Üçeyler, Nurcan},
   article_number = {10},
   doi = {http://dx.doi.org/10.1097/j.pain.0000000000001623},
   keywords = {Nerve lesion; Neuropathic pain; Sensory profile; Quantitative sensory testing; mRNA},
   language = {eng},
   issn = {0304-3959},
   journal = {Pain},
   title = {Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion},
   url = {http://dx.doi.org/10.1097/j.pain.0000000000001623},
   volume = {160},
   year = {2019}
}

TY  - JOUR
ID  - 1609602
AU  - Held, Melissa - Karl, Franziska - Vlčková, Eva - Rajdová, Aneta - Escolano-Lozano, Fabiola - Stetter, Christian - Bharti, Richa - Förstner, Konrad U. - Dušek, Ladislav - Leinders, Mathias - Birklein, Frank - Bednařík, Josef - Sommer, Claudia - Üçeyler, Nurcan
PY  - 2019
TI  - Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion
JF  - Pain
VL  - 160
IS  - 10
SP  - 2316-2327
EP  - 2316-2327
PB  - LIPPINCOTT WILLIAMS & WILKINS
SN  - 03043959
KW  - Nerve lesion
KW  - Neuropathic pain
KW  - Sensory profile
KW  - Quantitative sensory testing
KW  - mRNA
UR  - http://dx.doi.org/10.1097/j.pain.0000000000001623
L2  - http://dx.doi.org/10.1097/j.pain.0000000000001623
N2  - In this multicenter cross-sectional study, we determined sensory profiles of patients with (NL-1) and without neuropathic pain (NL-0) after nerve lesion and assessed immune-related systemic gene expression. Patients and matched healthy controls filled in questionnaires and underwent neurological examination, neurophysiological studies, quantitative sensory testing, and blood withdrawal. Neuropathic pain was present in 67/95 (71%) patients (NL-1). Tactile hyperalgesia was the most prominent clinical sign in NL-1 patients (P , 0.05). Questionnaires showed an association between neuropathic pain and the presence of depression, anxiety, and catastrophizing (P , 0.05 to P , 0.01). Neuropathic pain was frequently accompanied by other chronic pain (P , 0.05). Quantitative sensory testing showed ipsilateral signs of small and large fiber impairment compared to the respective contralateral side, with elevated thermal and mechanical detection thresholds (P , 0.001 to P , 0.05) and lowered pressure pain threshold (P , 0.05). Also, more loss of function was found in patients with NL-1 compared to NL-0. Pain intensity was associated with mechanical hyperalgesia (P , 0.05 to P , 0.01). However, quantitative sensory testing did not detect or predict neuropathic pain. Gene expression of peptidylglycine a-amidating monooxygenase was higher in NL patients compared with healthy controls (NL-1, P , 0.01; NL-0, P , 0.001). Also, gene expression of tumor necrosis factor-a was higher in NL-1 patients compared with NL-0 (P , 0.05), and interleukin-1ß was higher, but IL-10 was lower in NL-1 patients compared with healthy controls (P , 0.05 each). Our study reveals that nerve lesion presents with small and large nerve fiber dysfunction, which may contribute to the presence and intensity of neuropathic pain and which is associated with a systemic proinflammatory pattern.
ER  -

HELD, Melissa, Franziska KARL, Eva VLČKOVÁ, Aneta RAJDOVÁ, Fabiola ESCOLANO-LOZANO, Christian STETTER, Richa BHARTI, Konrad U. FÖRSTNER, Ladislav DUŠEK, Mathias LEINDERS, Frank BIRKLEIN, Josef BEDNAŘÍK, Claudia SOMMER a Nurcan Ü$\backslash$C CEYLER. Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion. \textit{Pain}. LIPPINCOTT WILLIAMS \&{} WILKINS, 2019, roč.~160, č.~10, s.~2316-2327. ISSN~0304-3959. Dostupné z: https://dx.doi.org/10.1097/j.pain.0000000000001623.

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