KEIL, Radan, J KOŽELUHOVÁ, Jiří DOLINA, Aleš HEP, Radek KROUPA, Vladimír KOJECKÝ, T KREJČÍ, J HAVLÍN, I HADAČOVÁ, J SEGETHOVÁ, P KOPTOVÁ, Z ZÁDOROVÁ, J MATOUŠ, B FRÝBOVÁ, P CHMÁTAL, M WASSERBAUER, J ŠŤOVÍČEK, M BAE, T GUVEN, M ZAEEM and Š HLAVA. Acute portal vein thrombosis in noncirrhotic patients–different prognoses based on presence of inflammatory markers: a long-term multicenter retrospective analysis. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. Informa Healthcare, 2019, vol. 54, No 11, p. 1379-1384. ISSN 0425-4929. Available from: https://dx.doi.org/10.1080/00365521.2019.1677768. |
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@article{1610336, author = {Keil, Radan and Koželuhová, J and Dolina, Jiří and Hep, Aleš and Kroupa, Radek and Kojecký, Vladimír and Krejčí, T and Havlín, J and Hadačová, I and Segethová, J and Koptová, P and Zádorová, Z and Matouš, J and Frýbová, B and Chmátal, P and Wasserbauer, M and Šťovíček, J and Bae, M and Guven, T and Zaeem, M and Hlava, Š}, article_number = {11}, doi = {http://dx.doi.org/10.1080/00365521.2019.1677768}, keywords = {Acute portal vein thrombosis; hemato-oncologic disease; prothrombotic factors}, language = {eng}, issn = {0425-4929}, journal = {SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY}, title = {Acute portal vein thrombosis in noncirrhotic patients–different prognoses based on presence of inflammatory markers: a long-term multicenter retrospective analysis}, url = {http://dx.doi.org/10.1080/00365521.2019.1677768}, volume = {54}, year = {2019} }
TY - JOUR ID - 1610336 AU - Keil, Radan - Koželuhová, J - Dolina, Jiří - Hep, Aleš - Kroupa, Radek - Kojecký, Vladimír - Krejčí, T - Havlín, J - Hadačová, I - Segethová, J - Koptová, P - Zádorová, Z - Matouš, J - Frýbová, B - Chmátal, P - Wasserbauer, M - Šťovíček, J - Bae, M - Guven, T - Zaeem, M - Hlava, Š PY - 2019 TI - Acute portal vein thrombosis in noncirrhotic patients–different prognoses based on presence of inflammatory markers: a long-term multicenter retrospective analysis JF - SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY VL - 54 IS - 11 SP - 1379-1384 EP - 1379-1384 PB - Informa Healthcare SN - 04254929 KW - Acute portal vein thrombosis KW - hemato-oncologic disease KW - prothrombotic factors UR - http://dx.doi.org/10.1080/00365521.2019.1677768 L2 - http://dx.doi.org/10.1080/00365521.2019.1677768 N2 - Background: Portal vein thrombosis (PVT) is a partial or complete thrombotic occlusion of the portal vein and is rare in noncirrhotic patients. Patients and methods: 78 adult patients with noncirrhotic acute PVT without known malignity were evaluated. Patients with initial CRP level 61–149 mg/l were excluded. Results: Patients were divided into two groups–the first one (33 patients) was characterized with signs of inflammation and CRP over 149 mg/l. The second group (45 patients) was without signs of inflammation and CRP level less than 61 mg/l. The frequency of prothrombotic hematologic factors was statistically significantly different in levels of factor VIII and MTHFR 677 C mutation. All patients from both groups underwent the same oncologic and hemato-oncologic screening which was positive in 23 patients (51.1%) in the group without signs of inflammation. In the group of patients with clinical and laboratory signs of inflammation oncologic and hemato-oncologic screening was positive only in 1 patient (3.0%). Complete portal vein recanalization was achieved in 19.2%, partial recanalization in 26.9%. Conclusions: Patients with clinical signs of inflammation and acute PVT have a low risk of malignancy in contrast to patients without signs of inflammation and acute PVT, which have a high risk of oncologic or hemato-oncologic disease. Patients with negative hemato-oncologic screening should be carefully observed over time because we expect they are at higher risk for the development of hemato-oncologic disease, independent from the presence and number of procoagulation risk factors. ER -
KEIL, Radan, J KOŽELUHOVÁ, Jiří DOLINA, Aleš HEP, Radek KROUPA, Vladimír KOJECKÝ, T KREJČÍ, J HAVLÍN, I HADAČOVÁ, J SEGETHOVÁ, P KOPTOVÁ, Z ZÁDOROVÁ, J MATOUŠ, B FRÝBOVÁ, P CHMÁTAL, M WASSERBAUER, J ŠŤOVÍČEK, M BAE, T GUVEN, M ZAEEM and Š HLAVA. Acute portal vein thrombosis in noncirrhotic patients–different prognoses based on presence of inflammatory markers: a long-term multicenter retrospective analysis. \textit{SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY}. Informa Healthcare, 2019, vol.~54, No~11, p.~1379-1384. ISSN~0425-4929. Available from: https://dx.doi.org/10.1080/00365521.2019.1677768.
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