Psoas density is associated with postoperative mortality after resection for colon cancer

PEKAŘ, Matej, Anna PEKAŘOVÁ, Lucia HAVRLENTOVÁ, Zdeněk JANDA, Miloslav MAZUR and Zuzana NOVÁKOVÁ. Psoas density is associated with postoperative mortality after resection for colon cancer. In PragueONCO 2020. 2020.

Basic information

• Original name: Psoas density is associated with postoperative mortality after resection for colon cancer
• Authors: PEKAŘ, Matej, Anna PEKAŘOVÁ, Lucia HAVRLENTOVÁ, Zdeněk JANDA, Miloslav MAZUR and Zuzana NOVÁKOVÁ.
• Edition: PragueONCO 2020, 2020.

Other information

• Type of outcome: Presentations at conferences
• Confidentiality degree: is not subject to a state or trade secret
• Keywords in English: colon cancer, sarcopenia, 30-day mortality

Abstract

AIM: to evaluate computed tomography scans of total muscle area and radiation attenutation in patients before resection for colon cancer as a predictive factor for postoperative mortality. METHOD: In this retrospective study we examined 65 patients, who underwent a surgical curative resection for malignant colon carcinoma (mean age 68.5±10.8 years, BMI 28.51±5.9 kg/m2, 30-day mortality was 7.7%). Preoperative computed tomography scans were performed in every patient. We compared postoperative mortality in assotiation with an average psoas density (PD), total psoas muscle area (TPA) and total abdominal muscle area (TMA) at the third lumbar vertebra level. We used Mann-Whitney for statistical testing with 80 % power and the significance level of 0.05. RESULTS: We found statistically significant correlation in the psoas muscle radiation attenuation associated with postoperative 30-day mortality: survival vs. non-survival: PD: 42.7 vs. 34.0 HU, p=0.026. There were non-significant differences in TPA: 8.44 vs. 7.22 cm2/m2, p=0.39 and TMA: 72.66 vs. 71.26 cm2/m2, p=0.71. CONCLUSION: The results show the detectable changes in computed tomography scans associated with 30-day mortality in patients after colon cancer surgery. The significant difference is perceived only between the muscle radiation density and not the muscle area. This is caused by muscle´s fat infiltration, that does not affect the volume of muscle, however its function is impaired. Supported by: This publication was written with the support of the Specific University Research no. MUNI/A/1307/2019 provided by MŠMT.

Links

• MUNI/A/1307/2019, interní kód MU: Name: Kardiovaskulární systém od A do Z (Acronym: KAVASAZ)

Investor: Masaryk University, Category A