MiR-21 binding site SNP within ITGAM associated with psoriasis
susceptibility in women

J 2019

MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women

HRUŠKA, Pavel, Daniela KURUCZOVÁ, Vladimír VAŠKŮ a Julie DOBROVOLNÁ

Základní údaje

Originální název

MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women

Autoři

HRUŠKA, Pavel (203 Česká republika, garant, domácí), Daniela KURUCZOVÁ (703 Slovensko, domácí), Vladimír VAŠKŮ (203 Česká republika) a Julie DOBROVOLNÁ (203 Česká republika, domácí)

Vydání

Plos one, San Francisco, Public Library of Science, 2019, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.740

Kód RIV

RIV/00216224:14110/19:00112780

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1371/journal.pone.0218323

UT WoS

000484891700024

Klíčová slova anglicky

SYSTEMIC-LUPUS-ERYTHEMATOSUS; FUNCTIONAL POLYMORPHISM; INFLAMMATORY RESPONSES; GENETIC ASSOCIATION; MICRORNA-BINDING; EXPRESSION; RISK; MIR-146A; CD11B/CD18; LEUKOCYTES

Štítky

14110518, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 1. 2020 13:14, Mgr. Tereza Miškechová

Anotace

V originále

Background Great progress has been made in the understanding of inflammatory processes in psoriasis. However, clarifying the role of genetic variability in processes regulating inflammation, including post-transcriptional regulation by microRNA (miRNA), remains a challenge. Objectives We therefore investigated single nucleotide polymorphisms (SNPs) with a predicted change in the miRNA/mRNA interaction of genes involved in the psoriasis inflammatory processes. Methods Studied SNPs rs2910164 C/G-miR-146a, rs4597342 T/C-ITGAM, rs1368439 G/T-IL12B, rs1468488 C/T-IL17RA were selected using a bioinformatics analysis of psoriasis inflammation-associated genes. These SNPs were then genotyped using a large cohort of women with psoriasis (n = 241) and healthy controls (n = 516). Results No significant association with psoriasis was observed for rs2910164, rs1368439, and rs1468488 genotypes. However, the major allele T of rs4597342 -ITGAM was associated with approximately 28% higher risk for psoriasis in comparison to the patients with the C allele (OR = 1.28, 95% CI 1.01-1.61, p = 0.037). In case of genotypes, the effect of the T allele indicates the dominant model of disease penetrance as the CT and TT genotypes increase the chance of psoriasis up to 42% in comparison to CC homozygotes of rs4597342 (OR = 1.42, 95% CI = 1.05-1.94, p = 0.025). Conclusion SNP rs4597342 in 3'UTR of ITGAM influencing miR-21 binding may be considered a risk factor for psoriasis development. Upregulated miR-21 in psoriasis is likely to inhibit CD11b production in the case of the rs4597342 T allele which may lead to Mac-1 dysfunction, resulting in an aberrant function of innate immune cells and leading to the production of cytokines involved in psoriasis pathogenesis.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF16_013/0001761, projekt VaV

Název: RECETOX RI

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

HRUŠKA, Pavel, Daniela KURUCZOVÁ, Vladimír VAŠKŮ a Julie DOBROVOLNÁ. MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women. Plos one. San Francisco: Public Library of Science, 2019, roč. 14, č. 6, s. 1-11. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0218323.

@article{1612096,
   author = {Hruška, Pavel and Kuruczová, Daniela and Vašků, Vladimír and Dobrovolná, Julie},
   article_location = {San Francisco},
   article_number = {6},
   doi = {http://dx.doi.org/10.1371/journal.pone.0218323},
   keywords = {SYSTEMIC-LUPUS-ERYTHEMATOSUS; FUNCTIONAL POLYMORPHISM; INFLAMMATORY RESPONSES; GENETIC ASSOCIATION; MICRORNA-BINDING; EXPRESSION; RISK; MIR-146A; CD11B/CD18; LEUKOCYTES},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women},
   url = {http://dx.doi.org/10.1371/journal.pone.0218323},
   volume = {14},
   year = {2019}
}

TY  - JOUR
ID  - 1612096
AU  - Hruška, Pavel - Kuruczová, Daniela - Vašků, Vladimír - Dobrovolná, Julie
PY  - 2019
TI  - MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women
JF  - Plos one
VL  - 14
IS  - 6
SP  - 1-11
EP  - 1-11
PB  - Public Library of Science
SN  - 19326203
KW  - SYSTEMIC-LUPUS-ERYTHEMATOSUS
KW  - FUNCTIONAL POLYMORPHISM
KW  - INFLAMMATORY RESPONSES
KW  - GENETIC ASSOCIATION
KW  - MICRORNA-BINDING
KW  - EXPRESSION
KW  - RISK
KW  - MIR-146A
KW  - CD11B/CD18
KW  - LEUKOCYTES
UR  - http://dx.doi.org/10.1371/journal.pone.0218323
L2  - http://dx.doi.org/10.1371/journal.pone.0218323
N2  - Background Great progress has been made in the understanding of inflammatory processes in psoriasis. However, clarifying the role of genetic variability in processes regulating inflammation, including post-transcriptional regulation by microRNA (miRNA), remains a challenge. Objectives We therefore investigated single nucleotide polymorphisms (SNPs) with a predicted change in the miRNA/mRNA interaction of genes involved in the psoriasis inflammatory processes. Methods Studied SNPs rs2910164 C/G-miR-146a, rs4597342 T/C-ITGAM, rs1368439 G/T-IL12B, rs1468488 C/T-IL17RA were selected using a bioinformatics analysis of psoriasis inflammation-associated genes. These SNPs were then genotyped using a large cohort of women with psoriasis (n = 241) and healthy controls (n = 516). Results No significant association with psoriasis was observed for rs2910164, rs1368439, and rs1468488 genotypes. However, the major allele T of rs4597342 -ITGAM was associated with approximately 28% higher risk for psoriasis in comparison to the patients with the C allele (OR = 1.28, 95% CI 1.01-1.61, p = 0.037). In case of genotypes, the effect of the T allele indicates the dominant model of disease penetrance as the CT and TT genotypes increase the chance of psoriasis up to 42% in comparison to CC homozygotes of rs4597342 (OR = 1.42, 95% CI = 1.05-1.94, p = 0.025). Conclusion SNP rs4597342 in 3'UTR of ITGAM influencing miR-21 binding may be considered a risk factor for psoriasis development. Upregulated miR-21 in psoriasis is likely to inhibit CD11b production in the case of the rs4597342 T allele which may lead to Mac-1 dysfunction, resulting in an aberrant function of innate immune cells and leading to the production of cytokines involved in psoriasis pathogenesis.
ER  -

HRUŠKA, Pavel, Daniela KURUCZOVÁ, Vladimír VAŠKŮ a Julie DOBROVOLNÁ. MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women. \textit{Plos one}. San Francisco: Public Library of Science, 2019, roč.~14, č.~6, s.~1-11. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0218323.

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