J 2019

MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women

HRUŠKA, Pavel, Daniela KURUCZOVÁ, Vladimír VAŠKŮ and Julie DOBROVOLNÁ

Basic information

Original name

MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women

Authors

HRUŠKA, Pavel (203 Czech Republic, guarantor, belonging to the institution), Daniela KURUCZOVÁ (703 Slovakia, belonging to the institution), Vladimír VAŠKŮ (203 Czech Republic) and Julie DOBROVOLNÁ (203 Czech Republic, belonging to the institution)

Edition

Plos one, San Francisco, Public Library of Science, 2019, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30216 Dermatology and venereal diseases

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.740

RIV identification code

RIV/00216224:14110/19:00112780

Organization unit

Faculty of Medicine

DOI

UT WoS

000484891700024

Keywords in English

SYSTEMIC-LUPUS-ERYTHEMATOSUS; FUNCTIONAL POLYMORPHISM; INFLAMMATORY RESPONSES; GENETIC ASSOCIATION; MICRORNA-BINDING; EXPRESSION; RISK; MIR-146A; CD11B/CD18; LEUKOCYTES

Tags

Tags

International impact, Reviewed
Změněno: 28/1/2020 13:14, Mgr. Tereza Miškechová

Abstract

V originále

Background Great progress has been made in the understanding of inflammatory processes in psoriasis. However, clarifying the role of genetic variability in processes regulating inflammation, including post-transcriptional regulation by microRNA (miRNA), remains a challenge. Objectives We therefore investigated single nucleotide polymorphisms (SNPs) with a predicted change in the miRNA/mRNA interaction of genes involved in the psoriasis inflammatory processes. Methods Studied SNPs rs2910164 C/G-miR-146a, rs4597342 T/C-ITGAM, rs1368439 G/T-IL12B, rs1468488 C/T-IL17RA were selected using a bioinformatics analysis of psoriasis inflammation-associated genes. These SNPs were then genotyped using a large cohort of women with psoriasis (n = 241) and healthy controls (n = 516). Results No significant association with psoriasis was observed for rs2910164, rs1368439, and rs1468488 genotypes. However, the major allele T of rs4597342 -ITGAM was associated with approximately 28% higher risk for psoriasis in comparison to the patients with the C allele (OR = 1.28, 95% CI 1.01-1.61, p = 0.037). In case of genotypes, the effect of the T allele indicates the dominant model of disease penetrance as the CT and TT genotypes increase the chance of psoriasis up to 42% in comparison to CC homozygotes of rs4597342 (OR = 1.42, 95% CI = 1.05-1.94, p = 0.025). Conclusion SNP rs4597342 in 3'UTR of ITGAM influencing miR-21 binding may be considered a risk factor for psoriasis development. Upregulated miR-21 in psoriasis is likely to inhibit CD11b production in the case of the rs4597342 T allele which may lead to Mac-1 dysfunction, resulting in an aberrant function of innate immune cells and leading to the production of cytokines involved in psoriasis pathogenesis.

Links

EF15_003/0000469, research and development project
Name: Cetocoen Plus
EF16_013/0001761, research and development project
Name: RECETOX RI
LM2015051, research and development project
Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR