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@article{1612096, author = {Hruška, Pavel and Kuruczová, Daniela and Vašků, Vladimír and Dobrovolná, Julie}, article_location = {San Francisco}, article_number = {6}, doi = {http://dx.doi.org/10.1371/journal.pone.0218323}, keywords = {SYSTEMIC-LUPUS-ERYTHEMATOSUS; FUNCTIONAL POLYMORPHISM; INFLAMMATORY RESPONSES; GENETIC ASSOCIATION; MICRORNA-BINDING; EXPRESSION; RISK; MIR-146A; CD11B/CD18; LEUKOCYTES}, language = {eng}, issn = {1932-6203}, journal = {Plos one}, title = {MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women}, url = {http://dx.doi.org/10.1371/journal.pone.0218323}, volume = {14}, year = {2019} }
TY - JOUR ID - 1612096 AU - Hruška, Pavel - Kuruczová, Daniela - Vašků, Vladimír - Dobrovolná, Julie PY - 2019 TI - MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women JF - Plos one VL - 14 IS - 6 SP - 1-11 EP - 1-11 PB - Public Library of Science SN - 19326203 KW - SYSTEMIC-LUPUS-ERYTHEMATOSUS KW - FUNCTIONAL POLYMORPHISM KW - INFLAMMATORY RESPONSES KW - GENETIC ASSOCIATION KW - MICRORNA-BINDING KW - EXPRESSION KW - RISK KW - MIR-146A KW - CD11B/CD18 KW - LEUKOCYTES UR - http://dx.doi.org/10.1371/journal.pone.0218323 L2 - http://dx.doi.org/10.1371/journal.pone.0218323 N2 - Background Great progress has been made in the understanding of inflammatory processes in psoriasis. However, clarifying the role of genetic variability in processes regulating inflammation, including post-transcriptional regulation by microRNA (miRNA), remains a challenge. Objectives We therefore investigated single nucleotide polymorphisms (SNPs) with a predicted change in the miRNA/mRNA interaction of genes involved in the psoriasis inflammatory processes. Methods Studied SNPs rs2910164 C/G-miR-146a, rs4597342 T/C-ITGAM, rs1368439 G/T-IL12B, rs1468488 C/T-IL17RA were selected using a bioinformatics analysis of psoriasis inflammation-associated genes. These SNPs were then genotyped using a large cohort of women with psoriasis (n = 241) and healthy controls (n = 516). Results No significant association with psoriasis was observed for rs2910164, rs1368439, and rs1468488 genotypes. However, the major allele T of rs4597342 -ITGAM was associated with approximately 28% higher risk for psoriasis in comparison to the patients with the C allele (OR = 1.28, 95% CI 1.01-1.61, p = 0.037). In case of genotypes, the effect of the T allele indicates the dominant model of disease penetrance as the CT and TT genotypes increase the chance of psoriasis up to 42% in comparison to CC homozygotes of rs4597342 (OR = 1.42, 95% CI = 1.05-1.94, p = 0.025). Conclusion SNP rs4597342 in 3'UTR of ITGAM influencing miR-21 binding may be considered a risk factor for psoriasis development. Upregulated miR-21 in psoriasis is likely to inhibit CD11b production in the case of the rs4597342 T allele which may lead to Mac-1 dysfunction, resulting in an aberrant function of innate immune cells and leading to the production of cytokines involved in psoriasis pathogenesis. ER -
HRUŠKA, Pavel, Daniela KURUCZOVÁ, Vladimír VAŠKŮ a Julie DOBROVOLNÁ. MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women. \textit{Plos one}. San Francisco: Public Library of Science, 2019, roč.~14, č.~6, s.~1-11. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0218323.
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