Lycopene increases metabolic activity of rat liver CYP2B, CYP2D
and CYP3A.

J 2020

Lycopene increases metabolic activity of rat liver CYP2B, CYP2D and CYP3A.

NOSKOVÁ, Kristýna, Gabriela PŘIBYL DOVRTĚLOVÁ, Ondřej ZENDULKA, Markéta STRAKOŠOVÁ, Ondřej PEŠ et. al.

Basic information

Original name

Lycopene increases metabolic activity of rat liver CYP2B, CYP2D and CYP3A.

Authors

NOSKOVÁ, Kristýna (203 Czech Republic, belonging to the institution), Gabriela PŘIBYL DOVRTĚLOVÁ (203 Czech Republic, belonging to the institution), Ondřej ZENDULKA (203 Czech Republic, belonging to the institution), Markéta STRAKOŠOVÁ (203 Czech Republic, belonging to the institution), Ondřej PEŠ (203 Czech Republic, belonging to the institution) and Jan JUŘICA (203 Czech Republic, guarantor, belonging to the institution)

Edition

Pharmacological Reports, Heidelberg, Springer, 2020, 1734-1140

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.024

RIV identification code

RIV/00216224:14110/20:00115263

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s43440-019-00007-y

UT WoS

000522947600016

Keywords in English

Lycopene; Rat; Cytochrome; P450; CYP3A; Induction

Abstract

V originále

Lycopene as a naturally occurring carotenoid is a common part of the human diet. Several beneficial properties of lycopene have been identified, with the most studied being anti-cancer and antioxidant activity. However, no evidence of possible drug–drug or drug–food supplement interactions has been found. We studied the in vivo effect of lycopene on the selected rat liver cytochromes P450 (CYPs): CYP1A2, CYP2B, CYP2C11, CYP2C6, CYP2D, and CYP3A. Lycopene was administered to rats intragastrically at doses of 4, 20, and 100 mg/kg/day for 10 consecutive days. Total protein content, P450 Content, and metabolic activity of selected CYPs were evaluated in the rat liver microsomal fraction. Increased CYP2B, CYP2D, and CYP3A metabolic activities were observed in animals treated with the lycopene dose of 100 mg/kg/day. The content of CYP3A1 protein was increased by the dose of 100 mg/kg/day and CYP3A2 protein was increased by all administered doses of lycopene. The results of our study indicate that lycopene increased the metabolic activity of enzymes that are orthologues to the most clinically important human enzymes involved in xenobiotic metabolism. The risk of pharmacokinetic interactions between lycopene dietary supplements and co-administered drugs should be evaluated.

Links

MUNI/A/0976/2018, interní kód MU

Name: Příspěvek chemických a biochemických metodik ke studiu molekulární podstaty vybraných patologických stavů a onemocnění

Investor: Masaryk University, Category A

MUNI/A/1167/2019, interní kód MU

Name: Příspěvek (bio)chemických technik ke studiu molekulární podstaty vybraných patologických jevů a onemocnění

Investor: Masaryk University, Category A

MUNI/A/1550/2018, interní kód MU

Name: Farmakologický výzkum v oblasti farmakokinetiky, neuropsychofarmakologie a onkologie

Investor: Masaryk University, Category A

Citovat

NOSKOVÁ, Kristýna, Gabriela PŘIBYL DOVRTĚLOVÁ, Ondřej ZENDULKA, Markéta STRAKOŠOVÁ, Ondřej PEŠ and Jan JUŘICA. Lycopene increases metabolic activity of rat liver CYP2B, CYP2D and CYP3A. Pharmacological Reports. Heidelberg: Springer, 2020, vol. 72, No 1, p. 156-165. ISSN 1734-1140. Available from: https://dx.doi.org/10.1007/s43440-019-00007-y.

@article{1613836,
   author = {Nosková, Kristýna and Přibyl Dovrtělová, Gabriela and Zendulka, Ondřej and Strakošová, Markéta and Peš, Ondřej and Juřica, Jan},
   article_location = {Heidelberg},
   article_number = {1},
   doi = {http://dx.doi.org/10.1007/s43440-019-00007-y},
   keywords = {Lycopene; Rat; Cytochrome; P450; CYP3A; Induction},
   language = {eng},
   issn = {1734-1140},
   journal = {Pharmacological Reports},
   title = {Lycopene increases metabolic activity of rat liver CYP2B, CYP2D and CYP3A.},
   url = {https://link.springer.com/article/10.1007%2Fs43440-019-00007-y},
   volume = {72},
   year = {2020}
}

TY  - JOUR
ID  - 1613836
AU  - Nosková, Kristýna - Přibyl Dovrtělová, Gabriela - Zendulka, Ondřej - Strakošová, Markéta - Peš, Ondřej - Juřica, Jan
PY  - 2020
TI  - Lycopene increases metabolic activity of rat liver CYP2B, CYP2D and CYP3A.
JF  - Pharmacological Reports
VL  - 72
IS  - 1
SP  - 156-165
EP  - 156-165
PB  - Springer
SN  - 17341140
KW  - Lycopene
KW  - Rat
KW  - Cytochrome
KW  - P450
KW  - CYP3A
KW  - Induction
UR  - https://link.springer.com/article/10.1007%2Fs43440-019-00007-y
L2  - https://link.springer.com/article/10.1007%2Fs43440-019-00007-y
N2  - Lycopene as a naturally occurring carotenoid is a common part of the human diet. Several beneficial properties of lycopene have been identified, with the most studied being anti-cancer and antioxidant activity. However, no evidence of possible drug–drug or drug–food supplement interactions has been found. We studied the in vivo effect of lycopene on the selected rat liver cytochromes P450 (CYPs): CYP1A2, CYP2B, CYP2C11, CYP2C6, CYP2D, and CYP3A. Lycopene was administered to rats intragastrically at doses of 4, 20, and 100 mg/kg/day for 10 consecutive days. Total protein content, P450 Content, and metabolic activity of selected CYPs were evaluated in the rat liver microsomal fraction. Increased CYP2B, CYP2D, and CYP3A metabolic activities were observed in animals treated with the lycopene dose of 100 mg/kg/day. The content of CYP3A1 protein was increased by the dose of 100 mg/kg/day and CYP3A2 protein was increased by all administered doses of lycopene. The results of our study indicate that lycopene increased the metabolic activity of enzymes that are orthologues to the most clinically important human enzymes involved in xenobiotic metabolism. The risk of pharmacokinetic interactions between lycopene dietary supplements and co-administered drugs should be evaluated.
ER  -

NOSKOVÁ, Kristýna, Gabriela PŘIBYL DOVRTĚLOVÁ, Ondřej ZENDULKA, Markéta STRAKOŠOVÁ, Ondřej PEŠ and Jan JUŘICA. Lycopene increases metabolic activity of rat liver CYP2B, CYP2D and CYP3A. \textit{Pharmacological Reports}. Heidelberg: Springer, 2020, vol.~72, No~1, p.~156-165. ISSN~1734-1140. Available from: https://dx.doi.org/10.1007/s43440-019-00007-y.

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