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@article{1614616,
author = {Ďuriš, Kamil and Jurajda, Michal},
article_location = {HOBOKEN},
article_number = {1},
doi = {http://dx.doi.org/10.1002/jnr.24392},
keywords = {evolution; inflammation; stroke},
language = {eng},
issn = {0360-4012},
journal = {Journal of Neuroscience Research},
title = {Evolutionary concept of inflammatory response and stroke},
url = {http://dx.doi.org/10.1002/jnr.24392},
volume = {98},
year = {2020}
}
TY - JOUR
ID - 1614616
AU - Ďuriš, Kamil - Jurajda, Michal
PY - 2020
TI - Evolutionary concept of inflammatory response and stroke
JF - Journal of Neuroscience Research
VL - 98
IS - 1
SP - 98-104
EP - 98-104
PB - WILEY
SN - 03604012
KW - evolution
KW - inflammation
KW - stroke
UR - http://dx.doi.org/10.1002/jnr.24392
L2 - http://dx.doi.org/10.1002/jnr.24392
N2 - The immune system plays an important role under both physiological and pathological conditions. Immune surveillance as well as defense and healing processes are crucial for the organism, but the immune system has a natural tendency to act aggressively when excessively stimulated. We may assume that the immune system is not designed to deal with severe conditions, such as polytrauma or severe stroke, because these are not compatible with life in the wilderness and evolution has no chance to act in such cases. These conditions are associated with exaggerated/deregulated inflammatory response, which may cause more damage than initial pathology. In this article, we would like to sketch a basic concept of the immune system-brain interactions from the evolutionary point of view and to discuss some implications related to stroke.
ER -
ĎURIŠ, Kamil and Michal JURAJDA. Evolutionary concept of inflammatory response and stroke. \textit{Journal of Neuroscience Research}. HOBOKEN: WILEY, 2020, vol.~98, No~1, p.~98-104. ISSN~0360-4012. Available from: https://dx.doi.org/10.1002/jnr.24392.
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