Non-coding RNAs and Cardiac Arrhythmias

J 2020

Non-coding RNAs and Cardiac Arrhythmias

ŠUSTR, Filip, Zdeněk STÁREK, Miroslav SOUČEK a Jan NOVÁK

Základní údaje

Originální název

Non-coding RNAs and Cardiac Arrhythmias

Autoři

ŠUSTR, Filip (203 Česká republika, domácí), Zdeněk STÁREK (203 Česká republika, domácí), Miroslav SOUČEK (203 Česká republika, domácí) a Jan NOVÁK (203 Česká republika, garant, domácí)

Vydání

Advances in Experimental Medicine and Biology, Singapore, Springer, 2020, 0065-2598

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Singapur

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.622

Kód RIV

RIV/00216224:14110/20:00115272

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/978-981-15-1671-9_17

UT WoS

000539026500017

Klíčová slova anglicky

non-coding RNA; microRNA; arrhythmias; channels

Štítky

14110115, 14110116, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 9. 2021 10:14, Mgr. Tereza Miškechová

Anotace

V originále

Cardiac arrhythmias represent wide and heterogenic group of disturbances in the cardiac rhythm. Pathophysiology of individual arrhythmias is highly complex and dysfunction in ion channels/currents involved in generation or spreading of action potential is usually documented. Non-coding RNAs (ncRNAs) represent highly variable group of molecules regulating the heart expression program, including regulation of the expression of individual ion channels and intercellular connection proteins, e.g. connexins. Within this chapter, we will describe basic electrophysiological properties of the myocardium. We will focus on action potential generation and spreading in pacemaker and non-pacemaker cells, including description of individual ion channels (natrium, potassium and calcium) and their ncRNA-mediated regulation. Most of the studies have so far focused on microRNAs, thus, their regulatory function will be described into greater detail. Clinical consequences of altered ncRNA regulatory function will also be described together with potential future directions of the research in the field.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

MUNI/A/1475/2018, interní kód MU

Název: Diferenciální diagnostika a odhad prognózy interních nemocí 3 (Akronym: DIDIPRON 3)

Investor: Masarykova univerzita, Diferenciální diagnostika a odhad prognózy interních nemocí 3, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

ŠUSTR, Filip, Zdeněk STÁREK, Miroslav SOUČEK a Jan NOVÁK. Non-coding RNAs and Cardiac Arrhythmias. Advances in Experimental Medicine and Biology. Singapore: Springer, 2020, roč. 1229, č. 2020, s. 287-300. ISSN 0065-2598. Dostupné z: https://dx.doi.org/10.1007/978-981-15-1671-9_17.

@article{1614636,
   author = {Šustr, Filip and Stárek, Zdeněk and Souček, Miroslav and Novák, Jan},
   article_location = {Singapore},
   article_number = {2020},
   doi = {http://dx.doi.org/10.1007/978-981-15-1671-9_17},
   keywords = {non-coding RNA; microRNA; arrhythmias; channels},
   language = {eng},
   issn = {0065-2598},
   journal = {Advances in Experimental Medicine and Biology},
   title = {Non-coding RNAs and Cardiac Arrhythmias},
   url = {https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17},
   volume = {1229},
   year = {2020}
}

TY  - JOUR
ID  - 1614636
AU  - Šustr, Filip - Stárek, Zdeněk - Souček, Miroslav - Novák, Jan
PY  - 2020
TI  - Non-coding RNAs and Cardiac Arrhythmias
JF  - Advances in Experimental Medicine and Biology
VL  - 1229
IS  - 2020
SP  - 287-300
EP  - 287-300
PB  - Springer
SN  - 00652598
KW  - non-coding RNA
KW  - microRNA
KW  - arrhythmias
KW  - channels
UR  - https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17
L2  - https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17
N2  - Cardiac arrhythmias represent wide and heterogenic group of disturbances in the cardiac rhythm. Pathophysiology of individual arrhythmias is highly complex and dysfunction in ion channels/currents involved in generation or spreading of action potential is usually documented. Non-coding RNAs (ncRNAs) represent highly variable group of molecules regulating the heart expression program, including regulation of the expression of individual ion channels and intercellular connection proteins, e.g. connexins. Within this chapter, we will describe basic electrophysiological properties of the myocardium. We will focus on action potential generation and spreading in pacemaker and non-pacemaker cells, including description of individual ion channels (natrium, potassium and calcium) and their ncRNA-mediated regulation. Most of the studies have so far focused on microRNAs, thus, their regulatory function will be described into greater detail. Clinical consequences of altered ncRNA regulatory function will also be described together with potential future directions of the research in the field.
ER  -

ŠUSTR, Filip, Zdeněk STÁREK, Miroslav SOUČEK a Jan NOVÁK. Non-coding RNAs and Cardiac Arrhythmias. \textit{Advances in Experimental Medicine and Biology}. Singapore: Springer, 2020, roč.~1229, č.~2020, s.~287-300. ISSN~0065-2598. Dostupné z: https://dx.doi.org/10.1007/978-981-15-1671-9\_{}17.

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