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@article{1614636,
author = {Šustr, Filip and Stárek, Zdeněk and Souček, Miroslav and Novák, Jan},
article_location = {Singapore},
article_number = {2020},
doi = {http://dx.doi.org/10.1007/978-981-15-1671-9_17},
keywords = {non-coding RNA; microRNA; arrhythmias; channels},
language = {eng},
issn = {0065-2598},
journal = {Advances in Experimental Medicine and Biology},
title = {Non-coding RNAs and Cardiac Arrhythmias},
url = {https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17},
volume = {1229},
year = {2020}
}
TY - JOUR
ID - 1614636
AU - Šustr, Filip - Stárek, Zdeněk - Souček, Miroslav - Novák, Jan
PY - 2020
TI - Non-coding RNAs and Cardiac Arrhythmias
JF - Advances in Experimental Medicine and Biology
VL - 1229
IS - 2020
SP - 287-300
EP - 287-300
PB - Springer
SN - 00652598
KW - non-coding RNA
KW - microRNA
KW - arrhythmias
KW - channels
UR - https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17
L2 - https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17
N2 - Cardiac arrhythmias represent wide and heterogenic group of disturbances in the cardiac rhythm. Pathophysiology of individual arrhythmias is highly complex and dysfunction in ion channels/currents involved in generation or spreading of action potential is usually documented. Non-coding RNAs (ncRNAs) represent highly variable group of molecules regulating the heart expression program, including regulation of the expression of individual ion channels and intercellular connection proteins, e.g. connexins. Within this chapter, we will describe basic electrophysiological properties of the myocardium. We will focus on action potential generation and spreading in pacemaker and non-pacemaker cells, including description of individual ion channels (natrium, potassium and calcium) and their ncRNA-mediated regulation. Most of the studies have so far focused on microRNAs, thus, their regulatory function will be described into greater detail. Clinical consequences of altered ncRNA regulatory function will also be described together with potential future directions of the research in the field.
ER -
ŠUSTR, Filip, Zdeněk STÁREK, Miroslav SOUČEK a Jan NOVÁK. Non-coding RNAs and Cardiac Arrhythmias. \textit{Advances in Experimental Medicine and Biology}. Singapore: Springer, 2020, roč.~1229, č.~2020, s.~287-300. ISSN~0065-2598. Dostupné z: https://dx.doi.org/10.1007/978-981-15-1671-9\_{}17.
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