Další formáty:
BibTeX
LaTeX
RIS
@article{1614638,
author = {Ďuriš, Kamil and Lipková, Jolana and Šplíchal, Zbyněk and Madarászová, Tereza and Jurajda, Michal},
article_location = {NEW YORK},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s12975-018-0641-z},
keywords = {Subarachnoid hemorrhage; Inflammation; Early brain injury; Anesthesia recovery time},
language = {eng},
issn = {1868-4483},
journal = {TRANSLATIONAL STROKE RESEARCH},
title = {Early Inflammatory Response in the Brain and Anesthesia Recovery Time EvaluationAfter Experimental Subarachnoid Hemorrhage},
url = {http://dx.doi.org/10.1007/s12975-018-0641-z},
volume = {10},
year = {2019}
}
TY - JOUR
ID - 1614638
AU - Ďuriš, Kamil - Lipková, Jolana - Šplíchal, Zbyněk - Madarászová, Tereza - Jurajda, Michal
PY - 2019
TI - Early Inflammatory Response in the Brain and Anesthesia Recovery Time EvaluationAfter Experimental Subarachnoid Hemorrhage
JF - TRANSLATIONAL STROKE RESEARCH
VL - 10
IS - 3
SP - 308-318
EP - 308-318
PB - SPRINGER
SN - 18684483
KW - Subarachnoid hemorrhage
KW - Inflammation
KW - Early brain injury
KW - Anesthesia recovery time
UR - http://dx.doi.org/10.1007/s12975-018-0641-z
L2 - http://dx.doi.org/10.1007/s12975-018-0641-z
N2 - The main objective was to evaluate, whether the subarachnoid hemorrhage (SAH)-associated early inflammatory response has focal or global character, i.e., whether areas distant to hematoma may be affected by an early inflammatory response. The second objective was to evaluate the association of anesthesia recovery time for basic reflexes/neurological functions with severity of SAH. SAH was induced in rats using an endovascular perforation model. Anesthesia recovery time was evaluated for pain reaction recovery time (spinal level), spontaneous ventilation recovery time (brain stem level), and consciousness recovery time (neocortical level). mRNA expressions of TNF, IL-1, IL-6, ICAM-1, and VCAM-1 in areas adjacent and distant to hematoma were evaluated between 2 and 8h after SAH. Serum levels of TNF, IL-1, and IL-6 were assessed at 4 and 8h after SAH. Anesthesia recovery time of all selected parameters was associated with severity of SAH. The consciousness recovery time test had the best predictive value, while the spontaneous ventilation recovery time test was able to bring information in the shortest time. The mRNA expressions of pro-inflammatory cytokines were significantly increased in severe SAH groups in both adjacent and distant areas. The inflammatory response in mild/moderate SAH groups was less strong, peaking at 4h after SAH. Serum levels of pro-inflammatory cytokines were ambiguous. Anesthesia recovery time may be useful for bleeding severity prediction in the SAH model; however, further validation is needed. Severe subarachnoid hemorrhage is associated with the strong early inflammatory response, which has a global character, while mild subarachnoid hemorrhage is accompanied by a weaker inflammation.
ER -
ĎURIŠ, Kamil, Jolana LIPKOVÁ, Zbyněk ŠPLÍCHAL, Tereza MADARÁSZOVÁ a Michal JURAJDA. Early Inflammatory Response in the Brain and Anesthesia Recovery Time EvaluationAfter Experimental Subarachnoid Hemorrhage. \textit{TRANSLATIONAL STROKE RESEARCH}. NEW YORK: SPRINGER, 2019, roč.~10, č.~3, s.~308-318. ISSN~1868-4483. Dostupné z: https://dx.doi.org/10.1007/s12975-018-0641-z.
|
