Early Inflammatory Response in the Brain and Anesthesia
Recovery Time EvaluationAfter Experimental Subarachnoid
Hemorrhage

J 2019

Early Inflammatory Response in the Brain and Anesthesia Recovery Time EvaluationAfter Experimental Subarachnoid Hemorrhage

ĎURIŠ, Kamil, Jolana LIPKOVÁ, Zbyněk ŠPLÍCHAL, Tereza MADARÁSZOVÁ, Michal JURAJDA et. al.

Základní údaje

Originální název

Early Inflammatory Response in the Brain and Anesthesia Recovery Time EvaluationAfter Experimental Subarachnoid Hemorrhage

Autoři

ĎURIŠ, Kamil (203 Česká republika, domácí), Jolana LIPKOVÁ (203 Česká republika, domácí), Zbyněk ŠPLÍCHAL (203 Česká republika, domácí), Tereza MADARÁSZOVÁ (203 Česká republika, domácí) a Michal JURAJDA (203 Česká republika, garant, domácí)

Vydání

TRANSLATIONAL STROKE RESEARCH, NEW YORK, SPRINGER, 2019, 1868-4483

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.780

Kód RIV

RIV/00216224:14110/19:00108132

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s12975-018-0641-z

UT WoS

000468375700009

Klíčová slova anglicky

Subarachnoid hemorrhage; Inflammation; Early brain injury; Anesthesia recovery time

Štítky

14110224, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 6. 2020 09:36, Mgr. Tereza Miškechová

Anotace

V originále

The main objective was to evaluate, whether the subarachnoid hemorrhage (SAH)-associated early inflammatory response has focal or global character, i.e., whether areas distant to hematoma may be affected by an early inflammatory response. The second objective was to evaluate the association of anesthesia recovery time for basic reflexes/neurological functions with severity of SAH. SAH was induced in rats using an endovascular perforation model. Anesthesia recovery time was evaluated for pain reaction recovery time (spinal level), spontaneous ventilation recovery time (brain stem level), and consciousness recovery time (neocortical level). mRNA expressions of TNF, IL-1, IL-6, ICAM-1, and VCAM-1 in areas adjacent and distant to hematoma were evaluated between 2 and 8h after SAH. Serum levels of TNF, IL-1, and IL-6 were assessed at 4 and 8h after SAH. Anesthesia recovery time of all selected parameters was associated with severity of SAH. The consciousness recovery time test had the best predictive value, while the spontaneous ventilation recovery time test was able to bring information in the shortest time. The mRNA expressions of pro-inflammatory cytokines were significantly increased in severe SAH groups in both adjacent and distant areas. The inflammatory response in mild/moderate SAH groups was less strong, peaking at 4h after SAH. Serum levels of pro-inflammatory cytokines were ambiguous. Anesthesia recovery time may be useful for bleeding severity prediction in the SAH model; however, further validation is needed. Severe subarachnoid hemorrhage is associated with the strong early inflammatory response, which has a global character, while mild subarachnoid hemorrhage is accompanied by a weaker inflammation.

Návaznosti

GP14-23773P, projekt VaV

Název: Regulace zánětlivé odpovědi prostřednictvím mikroRNA na experimaentálním modelu subarachnoidálního krvácení

Investor: Grantová agentura ČR, Regulace zánětlivé odpovědi prostřednictvím mikroRNA na experimaentálním modelu subarachnoidálního krvácení

Citovat

ĎURIŠ, Kamil, Jolana LIPKOVÁ, Zbyněk ŠPLÍCHAL, Tereza MADARÁSZOVÁ a Michal JURAJDA. Early Inflammatory Response in the Brain and Anesthesia Recovery Time EvaluationAfter Experimental Subarachnoid Hemorrhage. TRANSLATIONAL STROKE RESEARCH. NEW YORK: SPRINGER, 2019, roč. 10, č. 3, s. 308-318. ISSN 1868-4483. Dostupné z: https://dx.doi.org/10.1007/s12975-018-0641-z.

@article{1614638,
   author = {Ďuriš, Kamil and Lipková, Jolana and Šplíchal, Zbyněk and Madarászová, Tereza and Jurajda, Michal},
   article_location = {NEW YORK},
   article_number = {3},
   doi = {http://dx.doi.org/10.1007/s12975-018-0641-z},
   keywords = {Subarachnoid hemorrhage; Inflammation; Early brain injury; Anesthesia recovery time},
   language = {eng},
   issn = {1868-4483},
   journal = {TRANSLATIONAL STROKE RESEARCH},
   title = {Early Inflammatory Response in the Brain and Anesthesia Recovery Time EvaluationAfter Experimental Subarachnoid Hemorrhage},
   url = {http://dx.doi.org/10.1007/s12975-018-0641-z},
   volume = {10},
   year = {2019}
}

TY  - JOUR
ID  - 1614638
AU  - Ďuriš, Kamil - Lipková, Jolana - Šplíchal, Zbyněk - Madarászová, Tereza - Jurajda, Michal
PY  - 2019
TI  - Early Inflammatory Response in the Brain and Anesthesia Recovery Time EvaluationAfter Experimental Subarachnoid Hemorrhage
JF  - TRANSLATIONAL STROKE RESEARCH
VL  - 10
IS  - 3
SP  - 308-318
EP  - 308-318
PB  - SPRINGER
SN  - 18684483
KW  - Subarachnoid hemorrhage
KW  - Inflammation
KW  - Early brain injury
KW  - Anesthesia recovery time
UR  - http://dx.doi.org/10.1007/s12975-018-0641-z
L2  - http://dx.doi.org/10.1007/s12975-018-0641-z
N2  - The main objective was to evaluate, whether the subarachnoid hemorrhage (SAH)-associated early inflammatory response has focal or global character, i.e., whether areas distant to hematoma may be affected by an early inflammatory response. The second objective was to evaluate the association of anesthesia recovery time for basic reflexes/neurological functions with severity of SAH. SAH was induced in rats using an endovascular perforation model. Anesthesia recovery time was evaluated for pain reaction recovery time (spinal level), spontaneous ventilation recovery time (brain stem level), and consciousness recovery time (neocortical level). mRNA expressions of TNF, IL-1, IL-6, ICAM-1, and VCAM-1 in areas adjacent and distant to hematoma were evaluated between 2 and 8h after SAH. Serum levels of TNF, IL-1, and IL-6 were assessed at 4 and 8h after SAH. Anesthesia recovery time of all selected parameters was associated with severity of SAH. The consciousness recovery time test had the best predictive value, while the spontaneous ventilation recovery time test was able to bring information in the shortest time. The mRNA expressions of pro-inflammatory cytokines were significantly increased in severe SAH groups in both adjacent and distant areas. The inflammatory response in mild/moderate SAH groups was less strong, peaking at 4h after SAH. Serum levels of pro-inflammatory cytokines were ambiguous. Anesthesia recovery time may be useful for bleeding severity prediction in the SAH model; however, further validation is needed. Severe subarachnoid hemorrhage is associated with the strong early inflammatory response, which has a global character, while mild subarachnoid hemorrhage is accompanied by a weaker inflammation.
ER  -

ĎURIŠ, Kamil, Jolana LIPKOVÁ, Zbyněk ŠPLÍCHAL, Tereza MADARÁSZOVÁ a Michal JURAJDA. Early Inflammatory Response in the Brain and Anesthesia Recovery Time EvaluationAfter Experimental Subarachnoid Hemorrhage. \textit{TRANSLATIONAL STROKE RESEARCH}. NEW YORK: SPRINGER, 2019, roč.~10, č.~3, s.~308-318. ISSN~1868-4483. Dostupné z: https://dx.doi.org/10.1007/s12975-018-0641-z.

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