The role of uterine microbiome and epithelial-mesenchymal
transition in endometrial function

J 2019

The role of uterine microbiome and epithelial-mesenchymal transition in endometrial function

CRHA, Karel, Pavel VENTRUBA, Jana ŽÁKOVÁ, Michal JEŠETA, Radovan PILKA et. al.

Základní údaje

Originální název

The role of uterine microbiome and epithelial-mesenchymal transition in endometrial function

Autoři

CRHA, Karel (203 Česká republika, domácí), Pavel VENTRUBA (203 Česká republika, domácí), Jana ŽÁKOVÁ (203 Česká republika, domácí), Michal JEŠETA (203 Česká republika, garant, domácí), Radovan PILKA (203 Česká republika), Jan VODIČKA (203 Česká republika) a Igor CRHA (203 Česká republika, domácí)

Vydání

Medical Journal of Cell Biology, Walter de Gruyter, 2019, 2544-3577

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14110/19:00108588

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.2478/acb-2019-0020

Klíčová slova anglicky

embryo implantation; endometrial receptivity; endometrial regeneration; endometrium; epithelial-mesenchymal transition; uterine microbiome

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 2. 2020 14:13, Mgr. Tereza Miškechová

Anotace

V originále

Reproductive period in woman is characterized by cyclic changes of endometrium and its regeneration. The factors important for proper function of the endometrium are anatomical structure, hormonal control and signalling pathways on molecular-genetic level. New knowledge on uterine microbiome, mutual epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) of endometrial cells refine our conception of changes on cellular level, endometrial receptivity and possible causes of endometrial dysfunction. Substantial information on bacterial colonisation of endometrium were discovered by new diagnostic methods using analysis of ribosomal RNA in 16S subunit which are able to detect and exactly identify bacteria that are not detectable by classic cultivation methods. Endometrial microbiome prevents development of pathogenous microorganisms and modulates function of endometrial cells. It has been proven that stromal cells contribute to regeneration of not only the endometrial stroma, but also of the epithelium. Activity of ovarian steroids and other factors leads to EMT/MET, which ensures different functions of endometrium throughout the menstrual cycle and pregnancy. The endometrial microbiome and mutual transition of stromal and epithelial endometrial cells are necessary for physiological functions of uterine mucosa including implantation and development of an embryo. © 2019 Karel Crha, Pavel Ventruba, Jana Žáková, Michal Ješeta, Radovan Pilka, Jan Vodička, Igor Crha, published by Sciendo.

Návaznosti

NV18-08-00412, projekt VaV

Název: Lidské embryonální kmenové buňky pro klinické aplikace: derivace a charakterizace

Investor: Ministerstvo zdravotnictví ČR, Lidské embryonální kmenové buňky pro klinické aplikace: derivace a charakterizace

Citovat

CRHA, Karel, Pavel VENTRUBA, Jana ŽÁKOVÁ, Michal JEŠETA, Radovan PILKA, Jan VODIČKA a Igor CRHA. The role of uterine microbiome and epithelial-mesenchymal transition in endometrial function. Medical Journal of Cell Biology. Walter de Gruyter, 2019, roč. 7, č. 3, s. 146-151. ISSN 2544-3577. Dostupné z: https://dx.doi.org/10.2478/acb-2019-0020.

@article{1614718,
   author = {Crha, Karel and Ventruba, Pavel and Žáková, Jana and Ješeta, Michal and Pilka, Radovan and Vodička, Jan and Crha, Igor},
   article_number = {3},
   doi = {http://dx.doi.org/10.2478/acb-2019-0020},
   keywords = {embryo implantation; endometrial receptivity; endometrial regeneration; endometrium; epithelial-mesenchymal transition; uterine microbiome},
   language = {eng},
   issn = {2544-3577},
   journal = {Medical Journal of Cell Biology},
   title = {The role of uterine microbiome and epithelial-mesenchymal transition in endometrial function},
   url = {http://dx.doi.org/10.2478/acb-2019-0020},
   volume = {7},
   year = {2019}
}

TY  - JOUR
ID  - 1614718
AU  - Crha, Karel - Ventruba, Pavel - Žáková, Jana - Ješeta, Michal - Pilka, Radovan - Vodička, Jan - Crha, Igor
PY  - 2019
TI  - The role of uterine microbiome and epithelial-mesenchymal transition in endometrial function
JF  - Medical Journal of Cell Biology
VL  - 7
IS  - 3
SP  - 146-151
EP  - 146-151
PB  - Walter de Gruyter
SN  - 25443577
KW  - embryo implantation
KW  - endometrial receptivity
KW  - endometrial regeneration
KW  - endometrium
KW  - epithelial-mesenchymal transition
KW  - uterine microbiome
UR  - http://dx.doi.org/10.2478/acb-2019-0020
L2  - http://dx.doi.org/10.2478/acb-2019-0020
N2  - Reproductive period in woman is characterized by cyclic changes of endometrium and its regeneration. The factors important for proper function of the endometrium are anatomical structure, hormonal control and signalling pathways on molecular-genetic level. New knowledge on uterine microbiome, mutual epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) of endometrial cells refine our conception of changes on cellular level, endometrial receptivity and possible causes of endometrial dysfunction. Substantial information on bacterial colonisation of endometrium were discovered by new diagnostic methods using analysis of ribosomal RNA in 16S subunit which are able to detect and exactly identify bacteria that are not detectable by classic cultivation methods. Endometrial microbiome prevents development of pathogenous microorganisms and modulates function of endometrial cells. It has been proven that stromal cells contribute to regeneration of not only the endometrial stroma, but also of the epithelium. Activity of ovarian steroids and other factors leads to EMT/MET, which ensures different functions of endometrium throughout the menstrual cycle and pregnancy. The endometrial microbiome and mutual transition of stromal and epithelial endometrial cells are necessary for physiological functions of uterine mucosa including implantation and development of an embryo. © 2019 Karel Crha, Pavel Ventruba, Jana Žáková, Michal Ješeta, Radovan Pilka, Jan Vodička, Igor Crha, published by Sciendo.
ER  -

CRHA, Karel, Pavel VENTRUBA, Jana ŽÁKOVÁ, Michal JEŠETA, Radovan PILKA, Jan VODIČKA a Igor CRHA. The role of uterine microbiome and epithelial-mesenchymal transition in endometrial function. \textit{Medical Journal of Cell Biology}. Walter de Gruyter, 2019, roč.~7, č.~3, s.~146-151. ISSN~2544-3577. Dostupné z: https://dx.doi.org/10.2478/acb-2019-0020.

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