Peripubertal treatment with cannabidiol reverses behavioral
alterations in Delta 9-THC animal model of schizophrenia

a 2019

Peripubertal treatment with cannabidiol reverses behavioral alterations in Delta 9-THC animal model of schizophrenia

ŠTARK, Tibor, Giovanni GIURDANELLA, Vladimír PEKAŘÍK, Martin KUCHAR, Zuzana BABINSKÁ et. al.

Základní údaje

Originální název

Peripubertal treatment with cannabidiol reverses behavioral alterations in Delta 9-THC animal model of schizophrenia

Autoři

ŠTARK, Tibor (703 Slovensko, garant, domácí), Giovanni GIURDANELLA (380 Itálie), Vladimír PEKAŘÍK (203 Česká republika, domácí), Martin KUCHAR (203 Česká republika), Zuzana BABINSKÁ (703 Slovensko, domácí), Jana RUDÁ (203 Česká republika, domácí), Salvatore SALOMONE (380 Itálie), Raphael MECHOULAM, Filippo DRAGO (380 Itálie), Alexandra ŠULCOVÁ (203 Česká republika, domácí) a Vincenzo MICALE (380 Itálie)

Vydání

31st Congress of the European-College-of-Neuropsychopharmacology (ECNP), 2019

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30301 Social biomedical sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.853

Kód RIV

RIV/00216224:14110/19:00112856

Organizační jednotka

Lékařská fakulta

ISSN

DOI

http://dx.doi.org/10.1016/j.euroneuro.2018.11.407

UT WoS

000458400500350

Klíčová slova anglicky

Peripubertal treatment; annabidiol reverses behavioral alterations

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 4. 2020 13:22, Mgr. Tereza Miškechová

Anotace

V originále

Several studies suggest that disturbances in the neurodevelopment could lead to schizophrenia (SCZ), a psychiatric disorder with severe symptoms in cognitive and social domains. While a variety of studies emphasize the role of the endocannabinoid system (ECS) in the neurodevelopmental dysregulation during perinatal and adolescent periods, mostly arising fromwell-known long-lasting negative effects of delta-9-tetrahydrocannabinol very little attention is dedicated to the positive potential of the ECS modulation in these sensitive periods as a preventive intervention. Given that preventive antipsychotic treatment seems to reduce the risk of transition to psychosis in vulnerable individuals, we hypothesized early modulation of ECS could be a potential novel therapeutic strategy.

Návaznosti

MUNI/A/1132/2017, interní kód MU

Název: Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv

Investor: Masarykova univerzita, Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

ŠTARK, Tibor, Giovanni GIURDANELLA, Vladimír PEKAŘÍK, Martin KUCHAR, Zuzana BABINSKÁ, Jana RUDÁ, Salvatore SALOMONE, Raphael MECHOULAM, Filippo DRAGO, Alexandra ŠULCOVÁ a Vincenzo MICALE. Peripubertal treatment with cannabidiol reverses behavioral alterations in Delta 9-THC animal model of schizophrenia. In 31st Congress of the European-College-of-Neuropsychopharmacology (ECNP). 2019. ISSN 0924-977X. Dostupné z: https://dx.doi.org/10.1016/j.euroneuro.2018.11.407.

@proceedings{1615539,
   author = {Štark, Tibor and Giurdanella, Giovanni and Pekařík, Vladimír and Kuchar, Martin and Babinská, Zuzana and Rudá, Jana and Salomone, Salvatore and Mechoulam, Raphael and Drago, Filippo and Šulcová, Alexandra and Micale, Vincenzo},
   booktitle = {31st Congress of the European-College-of-Neuropsychopharmacology (ECNP)},
   doi = {http://dx.doi.org/10.1016/j.euroneuro.2018.11.407},
   keywords = {Peripubertal treatment; annabidiol reverses behavioral alterations},
   language = {eng},
   title = {Peripubertal treatment with cannabidiol reverses behavioral alterations in Delta 9-THC animal model of schizophrenia},
   url = {https://www.ecnp.eu/presentationpdfs/73/P.297.pdf},
   year = {2019}
}

TY  - CONF
ID  - 1615539
AU  - Štark, Tibor - Giurdanella, Giovanni - Pekařík, Vladimír - Kuchar, Martin - Babinská, Zuzana - Rudá, Jana - Salomone, Salvatore - Mechoulam, Raphael - Drago, Filippo - Šulcová, Alexandra - Micale, Vincenzo
PY  - 2019
TI  - Peripubertal treatment with cannabidiol reverses behavioral alterations in Delta 9-THC animal model of schizophrenia
KW  - Peripubertal treatment
KW  - annabidiol reverses behavioral alterations
UR  - https://www.ecnp.eu/presentationpdfs/73/P.297.pdf
L2  - https://www.ecnp.eu/presentationpdfs/73/P.297.pdf
N2  - Several studies suggest that disturbances in the neurodevelopment could lead to schizophrenia (SCZ), a psychiatric disorder with severe symptoms in cognitive and social domains. While a variety of studies emphasize the role of the endocannabinoid system (ECS) in the neurodevelopmental dysregulation during perinatal and adolescent periods, mostly arising fromwell-known long-lasting negative effects of delta-9-tetrahydrocannabinol very little attention is dedicated to the positive potential of the ECS modulation in these sensitive periods as a preventive intervention. Given that preventive antipsychotic treatment seems to reduce the risk of transition to psychosis in vulnerable individuals, we hypothesized early modulation of ECS could be a potential novel therapeutic strategy.
ER  -

ŠTARK, Tibor, Giovanni GIURDANELLA, Vladimír PEKAŘÍK, Martin KUCHAR, Zuzana BABINSKÁ, Jana RUDÁ, Salvatore SALOMONE, Raphael MECHOULAM, Filippo DRAGO, Alexandra ŠULCOVÁ a Vincenzo MICALE. Peripubertal treatment with cannabidiol reverses behavioral alterations in Delta 9-THC animal model of schizophrenia. In \textit{31st Congress of the European-College-of-Neuropsychopharmacology (ECNP)}. 2019. ISSN~0924-977X. Dostupné z: https://dx.doi.org/10.1016/j.euroneuro.2018.11.407.

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