| ORSAG, P., L. HAVRAN, L. FOJT, J. COUFAL, V. BRAZDA a Miroslav FOJTA. Voltammetric behavior of a candidate anticancer drug roscovitine at carbon electrodes in aqueous buffers and a cell culture medium. Monatshefte fur Chemie. Wien: Springer Wien, 2019, roč. 150, č. 3, s. 461-467. ISSN 0026-9247. Dostupné z: https://dx.doi.org/10.1007/s00706-018-2333-5. |
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@article{1621359,
author = {Orsag, P. and Havran, L. and Fojt, L. and Coufal, J. and Brazda, V. and Fojta, Miroslav},
article_location = {Wien},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s00706-018-2333-5},
keywords = {Roscovitine; Anticancer drug; Carbon electrodes; Voltammetry; Cell culture medium},
language = {eng},
issn = {0026-9247},
journal = {Monatshefte fur Chemie},
title = {Voltammetric behavior of a candidate anticancer drug roscovitine at carbon electrodes in aqueous buffers and a cell culture medium},
url = {https://link.springer.com/article/10.1007%2Fs00706-018-2333-5},
volume = {150},
year = {2019}
}
TY - JOUR
ID - 1621359
AU - Orsag, P. - Havran, L. - Fojt, L. - Coufal, J. - Brazda, V. - Fojta, Miroslav
PY - 2019
TI - Voltammetric behavior of a candidate anticancer drug roscovitine at carbon electrodes in aqueous buffers and a cell culture medium
JF - Monatshefte fur Chemie
VL - 150
IS - 3
SP - 461-467
EP - 461-467
PB - Springer Wien
SN - 00269247
KW - Roscovitine
KW - Anticancer drug
KW - Carbon electrodes
KW - Voltammetry
KW - Cell culture medium
UR - https://link.springer.com/article/10.1007%2Fs00706-018-2333-5
L2 - https://link.springer.com/article/10.1007%2Fs00706-018-2333-5
N2 - Roscovitine is a candidate anticancer drug acting as an inhibitor of cyclin-dependent kinases which are involved in cell-cycle control and in apoptosis triggering. In our present study,we show for the first time that roscovitine yields a well-developed, analytically useful signal due to its irreversible electrochemical oxidation in alkaline range of pH (while in acidic media, its oxidation process is apparently rather complex and corresponding voltammetric signals are less suitable for analytical purposes). We demonstrate the possibility of voltammetric determination of the drug in buffer solutions (down to submicromolar concentrations of roscovitine) as well as in cell culture medium (down to micromolar concentrations) using in-house-fabricated pyrolytic graphite or screen-printed carbon electrodes. [GRAPHICS] .
ER -
ORSAG, P., L. HAVRAN, L. FOJT, J. COUFAL, V. BRAZDA a Miroslav FOJTA. Voltammetric behavior of a candidate anticancer drug roscovitine at carbon electrodes in aqueous buffers and a cell culture medium. \textit{Monatshefte fur Chemie}. Wien: Springer Wien, 2019, roč.~150, č.~3, s.~461-467. ISSN~0026-9247. Dostupné z: https://dx.doi.org/10.1007/s00706-018-2333-5.
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