The role of cannabinoids in the treatment of cancer

J 2020

The role of cannabinoids in the treatment of cancer

VEČEŘA, Lubomír, Tomáš GABRHELÍK, Petr PRÁŠIL a Petr ŠTOURAČ

Základní údaje

Originální název

The role of cannabinoids in the treatment of cancer

Autoři

VEČEŘA, Lubomír (203 Česká republika, domácí), Tomáš GABRHELÍK (203 Česká republika, garant), Petr PRÁŠIL (203 Česká republika) a Petr ŠTOURAČ (203 Česká republika, domácí)

Vydání

Bratislava Medical Journal - Bratislavské lekárske listy, BRATISLAVA, Univerzita Komenského, 2020, 0006-9248

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30223 Anaesthesiology

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.278

Kód RIV

RIV/00216224:14110/20:00115321

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4149/BLL_2020_012

UT WoS

000507926100012

Klíčová slova anglicky

cannabinoids; cannabinoid receptor; cancer; oncological diseases; cancer treatment

Štítky

14110322, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 2. 2020 14:00, Mgr. Tereza Miškechová

Anotace

V originále

AIM: The aim of this review article is to summarize current knowledge about the role of cannabinoids and cannabinoid receptors in tumor disease modulation and to evaluate comprehensively the use of cannabinoids in cancer patients. METHOD: According to the PRISMA protocol, we have included data from a total of 105 articles. RESULTS: Cannabinoids affect cancer progression by three mechanisms. The most important mechanism is the stimulation of autophagy and affecting the signaling pathways leading to apoptosis. The most important mechanism of this process is the accumulation of ceramide. Cannabinoids also stimulate apoptosis by mechanisms independent of autophagy. Other mechanisms by which cannabinoids affect tumor growth are inhibition of tumor angiogenesis, invasiveness, metastasis, and the modulation of the anti-tumor immune response. CONCLUSION: In addition to the symptomatic therapy of cancer patients, the antitumor effects of cannabinoids (whether in monotherapy or in combination with other cancer therapies) have promising potential in the treatment of cancer patients. More clinical trials are needed to demonstrate the antitumor effect of cannabinoids (Tab. 1, Fig. 1, Ref. 167).

Citovat

VEČEŘA, Lubomír, Tomáš GABRHELÍK, Petr PRÁŠIL a Petr ŠTOURAČ. The role of cannabinoids in the treatment of cancer. Bratislava Medical Journal - Bratislavské lekárske listy. BRATISLAVA: Univerzita Komenského, 2020, roč. 121, č. 1, s. 79-95. ISSN 0006-9248. Dostupné z: https://dx.doi.org/10.4149/BLL_2020_012.

@article{1621456,
   author = {Večeřa, Lubomír and Gabrhelík, Tomáš and Prášil, Petr and Štourač, Petr},
   article_location = {BRATISLAVA},
   article_number = {1},
   doi = {http://dx.doi.org/10.4149/BLL_2020_012},
   keywords = {cannabinoids; cannabinoid receptor; cancer; oncological diseases; cancer treatment},
   language = {eng},
   issn = {0006-9248},
   journal = {Bratislava Medical Journal - Bratislavské lekárske listy},
   title = {The role of cannabinoids in the treatment of cancer},
   url = {http://dx.doi.org/10.4149/BLL_2020_012},
   volume = {121},
   year = {2020}
}

TY  - JOUR
ID  - 1621456
AU  - Večeřa, Lubomír - Gabrhelík, Tomáš - Prášil, Petr - Štourač, Petr
PY  - 2020
TI  - The role of cannabinoids in the treatment of cancer
JF  - Bratislava Medical Journal - Bratislavské lekárske listy
VL  - 121
IS  - 1
SP  - 79-95
EP  - 79-95
PB  - Univerzita Komenského
SN  - 00069248
KW  - cannabinoids
KW  - cannabinoid receptor
KW  - cancer
KW  - oncological diseases
KW  - cancer treatment
UR  - http://dx.doi.org/10.4149/BLL_2020_012
L2  - http://dx.doi.org/10.4149/BLL_2020_012
N2  - AIM: The aim of this review article is to summarize current knowledge about the role of cannabinoids and cannabinoid receptors in tumor disease modulation and to evaluate comprehensively the use of cannabinoids in cancer patients. METHOD: According to the PRISMA protocol, we have included data from a total of 105 articles. RESULTS: Cannabinoids affect cancer progression by three mechanisms. The most important mechanism is the stimulation of autophagy and affecting the signaling pathways leading to apoptosis. The most important mechanism of this process is the accumulation of ceramide. Cannabinoids also stimulate apoptosis by mechanisms independent of autophagy. Other mechanisms by which cannabinoids affect tumor growth are inhibition of tumor angiogenesis, invasiveness, metastasis, and the modulation of the anti-tumor immune response. CONCLUSION: In addition to the symptomatic therapy of cancer patients, the antitumor effects of cannabinoids (whether in monotherapy or in combination with other cancer therapies) have promising potential in the treatment of cancer patients. More clinical trials are needed to demonstrate the antitumor effect of cannabinoids (Tab. 1, Fig. 1, Ref. 167).
ER  -

VEČEŘA, Lubomír, Tomáš GABRHELÍK, Petr PRÁŠIL a Petr ŠTOURAČ. The role of cannabinoids in the treatment of cancer. \textit{Bratislava Medical Journal - Bratislavské lekárske listy}. BRATISLAVA: Univerzita Komenského, 2020, roč.~121, č.~1, s.~79-95. ISSN~0006-9248. Dostupné z: https://dx.doi.org/10.4149/BLL\_{}2020\_{}012.

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