Negative prognostic significance of primary cilia, CD8+tumor
infiltrating lymphocytes and PD1+cells expression in clear cell
renal cancer

J 2019

Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer

ROZSYPALOVA, Aneta, Blanka ROSOVA, Alzbeta FILIPOVA, Dimitar Hadzi NIKOLOV, Renata CHLOUPKOVÁ et. al.

Základní údaje

Originální název

Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer

Autoři

ROZSYPALOVA, Aneta (203 Česká republika), Blanka ROSOVA (203 Česká republika), Alzbeta FILIPOVA (203 Česká republika), Dimitar Hadzi NIKOLOV (203 Česká republika), Renata CHLOUPKOVÁ (203 Česká republika, domácí), Igor RICHTER (203 Česká republika), Jan PROKS (203 Česká republika), Roman ZACHOVAL (203 Česká republika), Radoslav MATEJ (203 Česká republika), Bohuslav MELICHAR (203 Česká republika), Tomas BUCHLER (203 Česká republika) a Josef DVORAK (203 Česká republika, garant)

Vydání

Journal of BUON, Athens, ZERBINIS MEDICAL PUBL, 2019, 1107-0625

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.695

Kód RIV

RIV/00216224:14110/19:00108594

Organizační jednotka

Lékařská fakulta

UT WoS

000481595900047

Klíčová slova anglicky

clear cell renal cancer; primary cilia; CD8+tumor infiltrating lymphocytes; programmed cell death protein 1

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 4. 2020 14:28, Mgr. Tereza Miškechová

Anotace

V originále

Purpose: The aim of this study was to investigate the potential association and combined prognostic significance of the frequency of primary cilia (PC), programmed cell death protein-1 receptor (PD1) and CD8+ tumor infiltrating lymphocytes (TIL) in patients with clear cell renal cancer (ccRCC). Methods: The frequency of PC, PD1 expression and the frequency of intratumoral CD8+ TIL were evaluated in 104 ccRCC patients. Results: The median frequency of PC was 0.003. The expression of PD1+ cells were <5% in 52 patients, 5-25% in 34 patients and 26-50% in 13 patients and >50% in 5 patients. Intratumoral CD8+ TIL were evaluable in all patients: negative in 1 patient, <25% in 63, 26-50% in 29 and >50% in 11 patients. Overall survival (OS) according to the frequency of PC was significantly shorter in patients with higher frequency (>= 0.002) than in patients with lower frequency (<0.002) (p<0.001). Median OS was significantly shorter in patients with higher (25%) CD8+ TIL and higher (>25%) PD1+ expression than in patients with lower (<25%) expression (4.6 vs. 97. years, p=0.006 and 2.9 vs. 8.9 years, p=0.006, respectively). Conclusions: The present study provides the first data on the potential association and combined prognostic significance of frequency of PC, PD1+ cells and CD8+ TIL in patients with clear cell renal cancer.

Návaznosti

NV15-34678A, projekt VaV

Název: Molekulární prognostické a prediktivní faktory u pacientů s metastatickým renálním karcinomem léčených tyrozinkinázovými inhibitory

Citovat

ROZSYPALOVA, Aneta, Blanka ROSOVA, Alzbeta FILIPOVA, Dimitar Hadzi NIKOLOV, Renata CHLOUPKOVÁ, Igor RICHTER, Jan PROKS, Roman ZACHOVAL, Radoslav MATEJ, Bohuslav MELICHAR, Tomas BUCHLER a Josef DVORAK. Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer. Journal of BUON. Athens: ZERBINIS MEDICAL PUBL, 2019, roč. 24, č. 4, s. 1644-1651. ISSN 1107-0625.

@article{1622917,
   author = {Rozsypalova, Aneta and Rosova, Blanka and Filipova, Alzbeta and Nikolov, Dimitar Hadzi and Chloupková, Renata and Richter, Igor and Proks, Jan and Zachoval, Roman and Matej, Radoslav and Melichar, Bohuslav and Buchler, Tomas and Dvorak, Josef},
   article_location = {Athens},
   article_number = {4},
   keywords = {clear cell renal cancer; primary cilia; CD8+tumor infiltrating lymphocytes; programmed cell death protein 1},
   language = {eng},
   issn = {1107-0625},
   journal = {Journal of BUON},
   title = {Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/31646820},
   volume = {24},
   year = {2019}
}

TY  - JOUR
ID  - 1622917
AU  - Rozsypalova, Aneta - Rosova, Blanka - Filipova, Alzbeta - Nikolov, Dimitar Hadzi - Chloupková, Renata - Richter, Igor - Proks, Jan - Zachoval, Roman - Matej, Radoslav - Melichar, Bohuslav - Buchler, Tomas - Dvorak, Josef
PY  - 2019
TI  - Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer
JF  - Journal of BUON
VL  - 24
IS  - 4
SP  - 1644-1651
EP  - 1644-1651
PB  - ZERBINIS MEDICAL PUBL
SN  - 11070625
KW  - clear cell renal cancer
KW  - primary cilia
KW  - CD8+tumor infiltrating lymphocytes
KW  - programmed cell death protein 1
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31646820
L2  - https://www.ncbi.nlm.nih.gov/pubmed/31646820
N2  - Purpose: The aim of this study was to investigate the potential association and combined prognostic significance of the frequency of primary cilia (PC), programmed cell death protein-1 receptor (PD1) and CD8+ tumor infiltrating lymphocytes (TIL) in patients with clear cell renal cancer (ccRCC). Methods: The frequency of PC, PD1 expression and the frequency of intratumoral CD8+ TIL were evaluated in 104 ccRCC patients. Results: The median frequency of PC was 0.003. The expression of PD1+ cells were <5% in 52 patients, 5-25% in 34 patients and 26-50% in 13 patients and >50% in 5 patients. Intratumoral CD8+ TIL were evaluable in all patients: negative in 1 patient, <25% in 63, 26-50% in 29 and >50% in 11 patients. Overall survival (OS) according to the frequency of PC was significantly shorter in patients with higher frequency (>= 0.002) than in patients with lower frequency (<0.002) (p<0.001). Median OS was significantly shorter in patients with higher (25%) CD8+ TIL and higher (>25%) PD1+ expression than in patients with lower (<25%) expression (4.6 vs. 97. years, p=0.006 and 2.9 vs. 8.9 years, p=0.006, respectively). Conclusions: The present study provides the first data on the potential association and combined prognostic significance of frequency of PC, PD1+ cells and CD8+ TIL in patients with clear cell renal cancer.
ER  -

ROZSYPALOVA, Aneta, Blanka ROSOVA, Alzbeta FILIPOVA, Dimitar Hadzi NIKOLOV, Renata CHLOUPKOVÁ, Igor RICHTER, Jan PROKS, Roman ZACHOVAL, Radoslav MATEJ, Bohuslav MELICHAR, Tomas BUCHLER a Josef DVORAK. Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer. \textit{Journal of BUON}. Athens: ZERBINIS MEDICAL PUBL, 2019, roč.~24, č.~4, s.~1644-1651. ISSN~1107-0625.

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